ID T1EFX4_HELRO Unreviewed; 482 AA.
AC T1EFX4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Amino acid permease/ SLC12A domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20195476 {ECO:0000313|EnsemblMetazoa:HelroP113916};
GN ORFNames=HELRODRAFT_113916 {ECO:0000313|EMBL:ESN98281.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP113916, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN98281.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP113916}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AMQM01005955; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097182; ESN98281.1; -; Genomic_DNA.
DR RefSeq; XP_009023619.1; XM_009025371.1.
DR AlphaFoldDB; T1EFX4; -.
DR STRING; 6412.T1EFX4; -.
DR EnsemblMetazoa; HelroT113916; HelroP113916; HelroG113916.
DR GeneID; 20195476; -.
DR KEGG; hro:HELRODRAFT_113916; -.
DR CTD; 20195476; -.
DR eggNOG; KOG1287; Eukaryota.
DR HOGENOM; CLU_007946_3_0_1; -.
DR InParanoid; T1EFX4; -.
DR OMA; HARIYAI; -.
DR OrthoDB; 5398046at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015179; F:L-amino acid transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0003333; P:amino acid transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR002293; AA/rel_permease1.
DR PANTHER; PTHR11785; AMINO ACID TRANSPORTER; 1.
DR PANTHER; PTHR11785:SF516; PUTATIVE-RELATED; 1.
DR Pfam; PF13520; AA_permease_2; 1.
DR PIRSF; PIRSF006060; AA_transporter; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..33
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 45..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 80..101
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 161..182
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 202..224
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..259
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 279..305
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 325..350
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..376
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..417
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 423..443
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 482 AA; 52710 MW; CCA4B678FBEBFEDA CRC64;
MAEEKIKLKR KLGLAHGMAI IIGLVVGGGI YITPQGVLMH AGSPGLTLII WIIGGIHSLF
GALCYAELGV NFPSAGAEYA YLSEMYSPYF GFMQLSIYLL LLRPGSNSFK AVLLGRYILK
PLYPDCQVPT KAVLCVASFM TMSMCALNYR SVKFSARGQS FMTSITITTL LCIIASGIYF
VVKGDVENLS EPFHHSATSV GDIVMSFYST VFAYSGWNAL NVLVEEVKNP KRTLPISIVV
SSLTLTILYT LVNYSYLVVL GKEGVLKSDA VAVSVGLRVW TPLAWVMSLC IAVTACASFN
SGILVGSRVA FAGARAGHLP EMISYVSLSY FTPVISVIAQ GILILVFIWF VTLDSIIKNL
TFCYAICELI VILGLVRIRL KERKNLDVYK DKLKMPLFVL LIYAVSLTII TIVPLVANFQ
ASALIFVIVV LVASAFYAAF VLWRPDFVTK NNAIDGMNNF VQKLFFCAPG GKNELTNKIL
ED
//
