GenomeNet

Database: UniProt
Entry: T1EGT8_HELRO
LinkDB: T1EGT8_HELRO
Original site: T1EGT8_HELRO 
ID   T1EGT8_HELRO            Unreviewed;       315 AA.
AC   T1EGT8;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   11-DEC-2019, entry version 36.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESN90489.1, ECO:0000313|EnsemblMetazoa:HelroP122071};
GN   Name=20195788 {ECO:0000313|EnsemblMetazoa:HelroP122071};
GN   ORFNames=HELRODRAFT_122071 {ECO:0000313|EMBL:ESN90489.1};
OS   Helobdella robusta (Californian leech).
OC   Eukaryota; Metazoa; Lophotrochozoa; Annelida; Clitellata; Hirudinea;
OC   Hirudinida; Glossiphoniiformes; Glossiphoniidae; Helobdella.
OX   NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP122071, ECO:0000313|Proteomes:UP000015101};
RN   [1] {ECO:0000313|EnsemblMetazoa:HelroP122071, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RA   Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA   Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA   Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA   Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA   Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESN90489.1, ECO:0000313|EnsemblMetazoa:HelroP122071, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
RN   [3] {ECO:0000313|EnsemblMetazoa:HelroP122071}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822}; Multi-
CC       pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AMQM01002268; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KB097753; ESN90489.1; -; Genomic_DNA.
DR   RefSeq; XP_009031416.1; XM_009033168.1.
DR   STRING; 6412.HelroP122071; -.
DR   EnsemblMetazoa; HelroT122071; HelroP122071; HelroG122071.
DR   GeneID; 20195788; -.
DR   KEGG; hro:HELRODRAFT_122071; -.
DR   CTD; 20195788; -.
DR   KO; K05330; -.
DR   OMA; VFSHYAT; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000015101; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Ion channel {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822, ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM        44..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        117..142
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          7..147
FT                   /note="IRK"
FT                   /evidence="ECO:0000259|Pfam:PF01007"
FT   DOMAIN          154..314
FT                   /note="IRK_C"
FT                   /evidence="ECO:0000259|Pfam:PF17655"
SQ   SEQUENCE   315 AA;  36613 MW;  66847E53F202C8B1 CRC64;
     KNNQRLVFKD GSCNVTTGNI MERRRKYLVD IFTTLVDMKW RYNFLMFVSG FLASWLFFAV
     CWFIVTISHE DHINYGNENW KPCLGNVYDF TTALLFSIET QQTIGYGFRG AEPNCPYVIF
     ILMMQCCVGV FIQSLTAGII FAKLSQPKRR AHTLLFSRKA VICNRDGEYC LLFRVGNMRK
     SHFVGTSIRA FIVKDKYTKE GECIPLCQNP LDIQPETCND DDFVFLVWPV TIIHKINKTS
     PFWEMSLEKL QEEHFEIIVI LEGIVESTGM TTQVRTSFLP REILWGHRLA PLLTYQKENG
     QYKIDYSQFH AVIPI
//
DBGET integrated database retrieval system