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Database: UniProt
Entry: T1EGU3_HELRO
LinkDB: T1EGU3_HELRO
Original site: T1EGU3_HELRO 
ID   T1EGU3_HELRO            Unreviewed;       333 AA.
AC   T1EGU3;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   16-OCT-2019, entry version 36.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESO09884.1, ECO:0000313|EnsemblMetazoa:HelroP122255};
GN   Name=20195793 {ECO:0000313|EnsemblMetazoa:HelroP122255};
GN   ORFNames=HELRODRAFT_122255 {ECO:0000313|EMBL:ESO09884.1};
OS   Helobdella robusta (Californian leech).
OC   Eukaryota; Metazoa; Lophotrochozoa; Annelida; Clitellata; Hirudinea;
OC   Hirudinida; Glossiphoniiformes; Glossiphoniidae; Helobdella.
OX   NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP122255, ECO:0000313|Proteomes:UP000015101};
RN   [1] {ECO:0000313|EnsemblMetazoa:HelroP122255, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RA   Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Simakov O., Marletaz F.,
RA   Cho S.-J., Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T.,
RA   Lv J., Arendt D., Savage R., Osoegawa K., de Jong P., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESO09884.1, ECO:0000313|EnsemblMetazoa:HelroP122255, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H.,
RA   Aerts A., Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V.,
RA   Lindberg D.R., Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
RN   [3] {ECO:0000313|EnsemblMetazoa:HelroP122255}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; AMQM01002833; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KB095905; ESO09884.1; -; Genomic_DNA.
DR   RefSeq; XP_009011698.1; XM_009013450.1.
DR   STRING; 6412.HelroP122255; -.
DR   EnsemblMetazoa; HelroT122255; HelroP122255; HelroG122255.
DR   GeneID; 20195793; -.
DR   KEGG; hro:HELRODRAFT_122255; -.
DR   CTD; 20195793; -.
DR   OMA; MSQAQME; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000015101; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000015101};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     51     74       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    123    147       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       13    153       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      160    332       IRK_C. {ECO:0000259|Pfam:PF17655}.
SQ   SEQUENCE   333 AA;  38392 MW;  EC00050C52BD9F93 CRC64;
     RTFVAGKHKR RLVQKSGECN VTSCNVTKRK QKYFFDIFTT LIDMRWRFHT LLFFAAFVTT
     WCVFGFVWFL IAIAHKDHIS HANETSTPCV TNVYDYTSAL LFSIETQTTI GYGYRVIQTE
     CPFAIFVLMM QSCIGLLIQS FITGVIFSKL SRPKGRSQTI MFSEKAVISK RDNEYNLQFR
     VGDMRKSHII GTSIRAVLVK NRLTSEGESI PLCQFPLVLE TEMSPSDSFV FLIWPVTVVH
     RINEKSPLWT MSLENLLQEH FEIIVLLEGT IESTGMATQV RTSYIPIEIM WGERLVPLLT
     FQLQNGRYEI DYSQFHNTSS IEMPECSAKE YAE
//
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