ID T1EHZ4_HELRO Unreviewed; 350 AA.
AC T1EHZ4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=FAM69 protein-kinase domain-containing protein {ECO:0000259|Pfam:PF12260};
GN Name=20196194 {ECO:0000313|EnsemblMetazoa:HelroP132750};
GN ORFNames=HELRODRAFT_132750 {ECO:0000313|EMBL:ESO07205.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP132750, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO07205.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP132750}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the DIPK family.
CC {ECO:0000256|ARBA:ARBA00006338}.
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DR EMBL; AMQM01003580; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096222; ESO07205.1; -; Genomic_DNA.
DR RefSeq; XP_009014583.1; XM_009016335.1.
DR AlphaFoldDB; T1EHZ4; -.
DR STRING; 6412.T1EHZ4; -.
DR EnsemblMetazoa; HelroT132750; HelroP132750; HelroG132750.
DR GeneID; 20196194; -.
DR KEGG; hro:HELRODRAFT_132750; -.
DR CTD; 20196194; -.
DR eggNOG; ENOG502QUEB; Eukaryota.
DR HOGENOM; CLU_052524_0_0_1; -.
DR InParanoid; T1EHZ4; -.
DR OMA; DICNHHL; -.
DR OrthoDB; 2919302at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR020519; DIPK2A/B.
DR InterPro; IPR022049; FAM69_kinase_dom.
DR PANTHER; PTHR32073; GH11358P; 1.
DR PANTHER; PTHR32073:SF7; GH11358P; 1.
DR Pfam; PF12260; PIP49_C; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}.
FT DOMAIN 152..348
FT /note="FAM69 protein-kinase"
FT /evidence="ECO:0000259|Pfam:PF12260"
SQ SEQUENCE 350 AA; 40043 MW; C59E9E41BE79D80E CRC64;
NVLNRPTFLE YDKCPACYGF KACSSIKNGE ILVDQSSSLN GLFYSNQHII HGKHVNGIDV
IISKLGGQHN TKAWEEKICT KAKKKQQCYI SEAAKELFPK SGSKWILEAV RGQSMMTACP
TERLISAITF RYTEMLDSID ISNTERIQLV LTIWRNQEPI IYQIFSKSTD WPFPQYLGAC
GRVVVYENPG KPLYTFYDEP WNFRIRLALK LLNIAHKFTF NPSQYGIYMM KVGADTFHYK
QETKELFYTS ARNILIVDKW QLEENKKENL VSNSDITKKC KHDEHWPSTT KNLCNGLYSD
HNYYAVCRNI LSPVNTEAGG SNAGLLHDVP HNVDTLFGLS HLMQSCLSPK
//
