ID T1EI50_HELRO Unreviewed; 251 AA.
AC T1EI50;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 42.
DE RecName: Full=Adenosine deaminase domain-containing protein {ECO:0000259|Pfam:PF00962};
GN Name=20196250 {ECO:0000313|EnsemblMetazoa:HelroP134508};
GN ORFNames=HELRODRAFT_134508 {ECO:0000313|EMBL:ESO01160.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP134508, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO01160.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP134508}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR EMBL; AMQM01005163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096830; ESO01160.1; -; Genomic_DNA.
DR RefSeq; XP_009020872.1; XM_009022624.1.
DR AlphaFoldDB; T1EI50; -.
DR STRING; 6412.T1EI50; -.
DR EnsemblMetazoa; HelroT134508; HelroP134508; HelroG134508.
DR GeneID; 20196250; -.
DR KEGG; hro:HELRODRAFT_134508; -.
DR CTD; 20196250; -.
DR eggNOG; KOG1097; Eukaryota.
DR HOGENOM; CLU_022829_0_0_1; -.
DR InParanoid; T1EI50; -.
DR OMA; GHRNDIN; -.
DR OrthoDB; 2952433at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0004000; F:adenosine deaminase activity; IBA:GO_Central.
DR GO; GO:0006154; P:adenosine catabolic process; IBA:GO_Central.
DR GO; GO:0046103; P:inosine biosynthetic process; IBA:GO_Central.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR InterPro; IPR001365; A_deaminase_dom.
DR InterPro; IPR006330; Ado/ade_deaminase.
DR InterPro; IPR032466; Metal_Hydrolase.
DR PANTHER; PTHR11409; ADENOSINE DEAMINASE; 1.
DR PANTHER; PTHR11409:SF39; ADENOSINE DEAMINASE 2; 1.
DR Pfam; PF00962; A_deaminase; 1.
DR SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 118..230
FT /note="Adenosine deaminase"
FT /evidence="ECO:0000259|Pfam:PF00962"
SQ SEQUENCE 251 AA; 28837 MW; A82A7BE4ACDCC51F CRC64;
KITKQIKEKY PSFIDYKRIS YTVRVLNYEL FEKNMNLAVQ LHTKYPQHLI GFDAVAEEDQ
GYSTLHYISQ YLSLQKNGVK IIPLYLHAAE TSWPDDLITG PFEDDPVSTL QNAYEAVLLN
VKRIGHGKGF VKKPYLMQLL KKMKIAVEVC VISNQILGMD ADLRNHFGQI LYKNGVPIIL
SPDDPGTFGY DNFTTDWYQA YTGWGLNLGD LKQLAVNSLT YNGMTDEERK IAIEQKWRPS
WEAFVNEVSN E
//
