ID T1EIY6_HELRO Unreviewed; 600 AA.
AC T1EIY6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
GN Name=20196536 {ECO:0000313|EnsemblMetazoa:HelroP139423};
GN ORFNames=HELRODRAFT_139423 {ECO:0000313|EMBL:ESN95611.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP139423, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN95611.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP139423}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01006719; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097510; ESN95611.1; -; Genomic_DNA.
DR RefSeq; XP_009026189.1; XM_009027941.1.
DR AlphaFoldDB; T1EIY6; -.
DR STRING; 6412.T1EIY6; -.
DR EnsemblMetazoa; HelroT139423; HelroP139423; HelroG139423.
DR GeneID; 20196536; -.
DR KEGG; hro:HELRODRAFT_139423; -.
DR CTD; 20196536; -.
DR eggNOG; KOG3594; Eukaryota.
DR HOGENOM; CLU_006480_3_2_1; -.
DR InParanoid; T1EIY6; -.
DR OMA; YAKVMID; -.
DR OrthoDB; 2948864at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 6.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028:SF146; CADHERIN FAMILY; 1.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF08266; Cadherin_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 7..119
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 120..227
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 228..335
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 340..443
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 444..558
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 600 AA; 66582 MW; BA298F995D08EE3D CRC64;
KELVYNVEEE TATGTYIGNI TKDLSLNQFY SPEVITRLSF TFLDKPVCEN KTCFNLNNET
GEISTACRLD RDKICPKAKE CFIEFNVAIQ PLNQTQNMKI KIVKIKIHIN DINDNEPVFS
PKTIQCSIAE NADVNTGTAI PTATDHDSPE NGIREYCDSQ TKFKLQCKTT VDGGSDLRLI
LTDKLDRETK DCYLLTVLAV DGGTPSKTGS ILINITVLDA NDNSPVFENS SYAVRVPENT
PVGAPILTVK ANDIDTGLNG QVTYEFEKFT ETKYGSFFSI KPEKGQIYLK NNLDYEETKT
FQLYVSARDK GPDAIAVIVS VEVIVQDVND HSPQIEVKTF SNEKSASVRE DAEIGTFVAL
LSVIDNDSGP NGKFSCEVND MTFKLNEVYV TELKVLTART LDRENQESYD LTFSCVDHGV
EPLTSTVPLK VKVEDVNDND PKFGVNSYVA SIRENSPVGA LLFSVHASDP DEGDNGRVTY
HVDEDVRGLI SVDERTGSIR SLVSFDYEQF HELNFNLTAK DNGNETTTNH LVEFHQQQTA
TTLVTIRIAD VNDNRPYFVY PASENQTLII PSKTPSGYVI TTIQAEDADL GANGDIVYQI
//