ID T1ELJ0_HELRO Unreviewed; 4424 AA.
AC T1ELJ0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN Name=20197440 {ECO:0000313|EnsemblMetazoa:HelroP155577};
GN ORFNames=HELRODRAFT_155577 {ECO:0000313|EMBL:ESO12478.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP155577, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO12478.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP155577}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AMQM01000172; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095811; ESO12478.1; -; Genomic_DNA.
DR RefSeq; XP_009009198.1; XM_009010950.1.
DR STRING; 6412.T1ELJ0; -.
DR EnsemblMetazoa; HelroT155577; HelroP155577; HelroG155577.
DR GeneID; 20197440; -.
DR KEGG; hro:HELRODRAFT_155577; -.
DR CTD; 20197440; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_4_0_1; -.
DR InParanoid; T1ELJ0; -.
DR OMA; QRENMAG; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 2.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017}; Membrane {ECO:0000256|SAM:Phobius};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 4394..4414
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1782..1918
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2387..2532
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2732..2870
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT COILED 2991..3025
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3205..3253
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4424 AA; 508395 MW; 996BB7AFC922E1AE CRC64;
MASATETAEA VDQRIEFIGD YISKTMKLRS ERWNRLYSVE ENKQMILDFF EKSDRTSLIF
SINISGVLTV SFSWPTTSKT KCVYFFKKSN EIIGKEPGWR QKIIFGDIGQ SPIQQFSLFL
EEVMLPILSN KKNCETWPRV IYEDIMQNVQ ELSSAAYVLS GLVKGRTLLP LPYNMPSSIN
ALQYTSARKL TAQSQQLVHD METLVIEWSN QIYEVLQKES DEPLIENLNP TPYVEIEFWE
SRYLNLDCIN DQLKCQKIEI MSEILERSYS VYNPLFVKLK KDVSEACEEA RDICLFLKPL
RLSLDDLEQV DFYDLSGKLS ILMHTVFTIW CHSKFYNTPE KAITLFQEIC NMLITKCRVY
LDPHELFKGE AEETAEKVDL TIKNMKSFKT IYSIYKGKVR EKAQNTPGMK DWEFPLHLIF
HRYDLFYKRV SDIMEVFSLQ LEFMKLEKIE FSGHKGGSLG NARKRIYEEF KESFKEFVDL
QCDILDPSDQ GFEKQHRTLK RVVEDLDVRL ATLICLGLDD ANGLEGVFKL LDSLGTLLDR
PTIKNDVDEK LPDIIKQMDD FLSETKQLYD DQINDIKSSG KVDLHVSMPK MSSHLEWAKG
LKERIAIHMT YFKRIEFSKD VSDVNAHYEE MIGLLNKFIN DVKAEWLSTV GNTCHDNLKK
FLSASHLYGR NEELWRFKTC LDLITQWYNE VKEALLEVEY PLIEEQLVVA DKQLELAEKH
YTWETAGAWE FITETKKCVS ELNKKLFQTK ANVDQMKKIM TTWSKTPLFD RSEGKTSTLL
NISDKEDKLK KRYSELSQAG IKIHQLVRDN LQLFGCSEQS DEWKAYVDFL DEMIVESFFL
IIQCSLHFLQ NNTVPLDGPA PLFETTMELQ APDIIFIPSM DEGVADGFFE IVDNLICDIY
KQASVISRLS TECGIANYQP DAESSEDLNK MRCDLMEHVN NMMLRAADFK QSFDSYVYLW
TDDRAEFLKQ FLLYNHVLTA EEIEAHGGDG IPENPPTLQQ FKDQIDHYEH LYKEVESIDG
VVVFENWFRI DARPFKQSLL NTIKKWALMF KQHLVSHVTT SLKELNDFIK VVGKGLSQQV
KEGDYDELIQ VMGHLLSVKE RQGSTDAMFE PLKESIELLK AYSQDVTDEV HLQLQELPEQ
WGNIKKLALT VKQQVAPLQA NEVANLRKKT ASFDVQQQEF RENFRKMPAY NYSCHNPYDV
LNEYQLKLTT IEKTMTSLVT SASLFEVAIP DFKHIKLCRR DIVLLKVLWD YVFCIRSTFD
DWKTTLWKRI NVEHMELESK KLTKVIRTLD KEMKPWDVFI GLDNTIKNMT TSLTAVNQLQ
NSAIRERHWM QLMRATGVRF TFDDKTTLSD LLSLKLHNFE DEVKNIVDKS VKELSMEKML
NSIHESWTDM QFEHEKHPRT GITLLKASET LIETLEENQV QLQNMLTSKH IAHFLEEVST
WQKKLSTADQ VISIWFEVQR TWSHLESIFI GSDDIRTQLP QDSERFDKID VDFKELVKEV
ETTTQVLETT SRPRLYERLE TIKDQLTLCE KALAEYLETK RLAFPRFYFV SAVDLLDILS
NGNQPSLVTR HLTKLFDSMA QLKFDDGKLS ADDGVARTAI AMWSKDDEFV HLSSPCDCSG
QVEVWLNRLL SCMRQTIRYE LTEALAASEE KMREQWLFEF PAQVALCCVQ ISQLNVLITM
LTGTLTPGDR QKIMTVCTIE VHNRDVVNKL IAQKVENSQA FTWLSQLRHR WDDKEEDCFA
NICDAQFKYS HEYLGNSTRL VITPLTDRCY ITLTQSLHLT MSGAPAGPAG TGKTETTKDL
GRTLGVMVYV FNCSEQMDYK SIGNIYKGLA QSGAWGCFDE FNRISVEVLS VVAVQVKCIQ
DAIKSKKKVF SFLGEEISLM SCVGIFITMN PGYAGRTELP ENLKALFRPC AMVVPDFELI
CEIMLVAEGF LDARLLARKF ITLYSLCKEL LSKQDHYDWG LRAIKSVLVV AGSLKRGDKE
RPEDQVLMRA LRDFNIPKIV TDDMPVFMGL IGDLFPALDV PRKRDDVLEK QIKTAISNLK
LQPEDGFILK VVQLQELFEV RHSVFIVGNA GTGKSCVWKT LYKANQNMKK KPIAVDLNPK
AVTNNELFGI INPATREWKD GLFSYVMRDL ANNSHDGPKW IILDGDIDPM WIESLNTVMD
DNKVLTLASN ERIPLTHSMR LLFEISHLKS ATPATVSRAG ILYINAGDLG WNPFISSWIE
TRQAQSEKAN LTILFDKYVP SCLEAMRLRF KKIIPITDIS HLQMLCYLLE CMLTPENTPA
DCPKEWYELY FVFSCIWAFG GCLFQDQLVD HRVEFTKWWV GEFKTIKFPA QGTVFDYYID
QETKKFELWS KKVPKFELDS EIPLQATMVH TSETTRIRYF LDLLLDKRRP VMLVGHAGTG
KTVLINDKIV SLSEDFVVAN VPFNFYTTSE MLQQILEKPL EKKAGKNYGP PGNKKLIYFI
DDMNMPERDR FSTVQPHTLI RQHLDYNHWY DRTKLTLKEI SNTQYVACMN QAAGNFTIDT
RLQRHFSVFA LSFPSQEALT SIYTNIIQQH LLEVGFPASV QKQCNNVVQA SLLLHQRITQ
TFQLTAIKFH YIFNLRDLSN VFQGILFAGL ECCKVASDLA RLWVHESQRT YRDKLVSHSD
LELFDKIIAE VVKKIFEDLD ENAIFKEPLQ FCHFASGIGE PKYLPVVSSA DISKILIDAL
ENYNEINSAM NLVLFDDAIS HVLRINRITE APRGNALLVG VGGSGKQSLS KLAAHISGYE
VFQITLKKGY GIPDLKQDLN GLYQKAGLKG LGMVLLMTDA HIIDERFLVL INDLLASGEI
PDLFTEDDLD IIVTGVRNDV KEMGLFDSRE NCWKFFIDRV RRQLKVILCF SPVGNTLRVR
SRNFPALTNC TSIDWFHEWP EEALISVSHR FLSEIELLDS GMRQSISQFV AYVHRSVNQV
SEIYLQNERR YNYTTPKSFL ELIQLYQNLL AKKHENLQAS VLRLETGLEK LKGSSSQVES
LKLKLAQQKQ ELAIKDEQAN KLINVVEADT IKVSKEKSLA SEEEKKVQVI NEEVQRRFKE
CQEDLAKAEP ALIEAKEALA TLNKSNLSEL KGFAKPVTAV VNVTAAVMVL LANKTKKIPK
DRTWNAAKVM MGKVDDFLNA LLNYEKENIP DVCRQAVQPY LQNPEFNAES IKQKSVAAAG
LCKWVINIMK YYAVYCDVEP KRQALNQATQ TRQAAEERLQ HIQSKIASLE EALSKLKAEY
DQATEAQIKC KQEADATNKT IILANRLVSG LTSENDRWTE QVKHFRRQET TLAGDMLLVA
AFISYIGCFT KQYRLMLIEK HWIPFLTDKL EVSIPFSEGF DPLSLLTDDA QVASWNNCGL
PSDRMSTENA AILINSERWP LIIDPQLQGL KWIKSQYSSS LVAVRLGQKG FLDRIEQAIS
NGDTVLIENI EETLDPVLEP VIARNLIKKG TAIRFGDKEV EYDKGFRLIL HTKLANPHYK
PELQAQTTLI NFTVTRDGLE DQLLADVVSK ERYDLEKSKA SLTKSQNTFK ISLKNLEDEL
LARLSTAEAN FLGDYALVEN LEKTKSMSSD IELKVAEAKV TESRINEARE AYRKAATRAS
LLYFILNDLN KIHPMYQFSL KAFSIVFEKA IDRAEPAEET PQRVQNLIDC ITYSVFIYTS
RGLFERDKLT FMAQTAFQIL NMNQDIDPQE LDFLLRLPAL PNVVSPVDFL NNQCWGAVKA
LALLDEFNNL DRDIEGSTKR WKKFVESEYP EKEKFPQEWK NKSSLQRMCM LRCLRPDRMT
YAVKLFVEEK LGSKFVETRS LDFSKSFEES GSGTPVMFIL SPGVDPLKDV ETLGVKLGFS
VDKSNFHNIS LGQGQEVVAE DAMEKASKSG HWVVLQNIHL VSRWLPALEK LLEQYSLESH
ADFRVFISAE PAPTKESHII PQGILEAAIK ITNEPPTGMF ANLHKALDNF SQDTLEMCAR
EAEFKSILFS LCYFHAVVSE RRKFGPQGWN RIYPFNTGDL TISINVLFNY LEANAKVPWE
DLRYLFGEIM YGGHITDDWD RRLCKTYLEE YMNPSLLDGE MNFAPGFPVP PNTDYRGYHS
FITECLPSES PHLYGLHPNS EIEFLTMTSE NLFRTVLEMQ PRDSGMANPL GLTREDKIKN
VLDEILEKIP EEFVMYDLIA KLPPEDRTPY VTVAFQECER MNLLTLEIKR SLKELDLGLK
GELTITADME LLGNALFLDM VPDSWIHLAY PSLYGLAQWH ADLVSRIKEL ESWVSDFQLP
SSVWLGGFFN PQSFLTAIMQ QMARKNEWPL DKMCLQCDVT KKNKEDMGAP PREGSYVHGL
YMEGARWDVQ TGLIAEARLK ELAPMMPVIF IKAIPVDRQD LRNIYECPTY KTKQRGNTFV
WTFNLKSKEK PAKWILAGVA LTLQVIFSFF WFIFRKFEYK RKEK
//