ID T1ELJ6_HELRO Unreviewed; 815 AA.
AC T1ELJ6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=AP-1 complex subunit gamma {ECO:0000256|PIRNR:PIRNR037094};
GN Name=20197446 {ECO:0000313|EnsemblMetazoa:HelroP155611};
GN ORFNames=HELRODRAFT_155611 {ECO:0000313|EMBL:ESO12914.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP155611, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO12914.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP155611}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC {ECO:0000256|PIRNR:PIRNR037094}.
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DR EMBL; AMQM01000260; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095811; ESO12914.1; -; Genomic_DNA.
DR RefSeq; XP_009009634.1; XM_009011386.1.
DR AlphaFoldDB; T1ELJ6; -.
DR STRING; 6412.T1ELJ6; -.
DR EnsemblMetazoa; HelroT155611; HelroP155611; HelroG155611.
DR GeneID; 20197446; -.
DR KEGG; hro:HELRODRAFT_155611; -.
DR CTD; 20197446; -.
DR eggNOG; KOG1062; Eukaryota.
DR HOGENOM; CLU_003824_0_0_1; -.
DR InParanoid; T1ELJ6; -.
DR OMA; AICAMRI; -.
DR OrthoDB; 25313at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0030121; C:AP-1 adaptor complex; IBA:GO_Central.
DR GO; GO:0035615; F:clathrin adaptor activity; IBA:GO_Central.
DR GO; GO:0006896; P:Golgi to vacuole transport; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 2.60.40.1230; -; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR017107; AP1_complex_gsu.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR InterPro; IPR013041; Clathrin_app_Ig-like_sf.
DR InterPro; IPR008153; GAE_dom.
DR PANTHER; PTHR22780; ADAPTIN, ALPHA/GAMMA/EPSILON; 1.
DR PANTHER; PTHR22780:SF5; AP-1 COMPLEX SUBUNIT GAMMA; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF02883; Alpha_adaptinC2; 1.
DR PIRSF; PIRSF037094; AP1_complex_gamma; 1.
DR SMART; SM00809; Alpha_adaptinC2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49348; Clathrin adaptor appendage domain; 1.
DR PROSITE; PS50180; GAE; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329,
KW ECO:0000256|PIRNR:PIRNR037094};
KW Golgi apparatus {ECO:0000256|PIRNR:PIRNR037094};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR037094};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR037094};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR037094}.
FT DOMAIN 697..810
FT /note="GAE"
FT /evidence="ECO:0000259|PROSITE:PS50180"
SQ SEQUENCE 815 AA; 91017 MW; 6901C3F64ADB46C9 CRC64;
MPTPKRLRDL IREIRSARTA ADERAVVQRE CAQIRDTFRE EDNTYRCRNV AKLLYIHMLG
YPAHFGQLEC LKLIASPRFT DKRIGYLGAM LLLDERQDIH LLVTNSLKND LNHQTQYVVS
LALCTLGAIC SAEMSRDLAG EVEKLIKSSN AYIKKKAALC AVRILRKVPD LMEMFIPATR
LLLNEKNHGV LLTAICLMIE MCEKSPDMLD HFRKMVPQLV RILKNLIMAG YSPEHDVSGI
SDPFLQVKIL CLLRILGRND PDSSEAMNDI LAQVATNTET SKNVGNAILY ETCLTIMNIN
SETGLRVLAV NILGRFLLNS DKNIRYVALN TLLRVVHADY NAVQRHRSTI VDCLKDPDIS
IKRRAMELGF ALVNGNNIRG MVKELFAFLE TCDPEFKADC SSSILLAAEK YAPNKRWHID
TVMKVLTTAG NYVRDDMVSC LIQLIQETNV LHVYTTHQLC KALMADISQQ PLAQVASWCI
GEYGNLLFVP TGSGGKDEDD DELVETTEEE VLELLERVLV NNNSTSTTKQ YVLTAIVKLS
TRFTHTLDQI RRLISIFAAS MNIELQQRST EYSTLFRTSD SIRIGLLEQM PILDKSGSTL
ANGDTPTISN DGMEDVYNKK NTQSECQNIL DVFGNDSPTT TGSTSLTANQ LSNKSAQNDL
LDLIFDINAG NANKPAHQPV MPNNNNASLI DGLIGMSISP GFVAFEKNGI KITFQCQRVD
DVTVNITMTT VNSSSQQFND FVFQAAVPKT FQLQLLSPSS NVLLPNNAGS INQIIKVTNP
NKQPIRMRIK VNYSINGQSY TEPGEVNNFP SCLWQ
//
