ID T1ELN0_HELRO Unreviewed; 185 AA.
AC T1ELN0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=ADP-ribosylation factor-like protein 8B-A {ECO:0008006|Google:ProtNLM};
GN Name=20197480 {ECO:0000313|EnsemblMetazoa:HelroP155828};
GN ORFNames=HELRODRAFT_155828 {ECO:0000313|EMBL:ESO02484.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP155828, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO02484.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP155828}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004656}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Arf family.
CC {ECO:0000256|ARBA:ARBA00010290}.
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DR EMBL; AMQM01000902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096742; ESO02484.1; -; Genomic_DNA.
DR RefSeq; XP_009019892.1; XM_009021644.1.
DR AlphaFoldDB; T1ELN0; -.
DR STRING; 6412.T1ELN0; -.
DR EnsemblMetazoa; HelroT155828; HelroP155828; HelroG155828.
DR GeneID; 20197480; -.
DR KEGG; hro:HELRODRAFT_155828; -.
DR CTD; 20197480; -.
DR eggNOG; KOG0075; Eukaryota.
DR HOGENOM; CLU_040729_10_0_1; -.
DR InParanoid; T1ELN0; -.
DR OMA; LIDQMCL; -.
DR OrthoDB; 607297at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:1904115; C:axon cytoplasm; IEA:GOC.
DR GO; GO:0005765; C:lysosomal membrane; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0008089; P:anterograde axonal transport; IBA:GO_Central.
DR GO; GO:0015031; P:protein transport; IEA:InterPro.
DR CDD; cd04159; Arl10_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR044154; Arl8a/8b.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR006689; Small_GTPase_ARF/SAR.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR45732; ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8; 1.
DR PANTHER; PTHR45732:SF7; ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 8; 1.
DR Pfam; PF00025; Arf; 1.
DR PRINTS; PR00328; SAR1GTPBP.
DR SMART; SM00177; ARF; 1.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00178; SAR; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51417; ARF; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51422; SAR1; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
SQ SEQUENCE 185 AA; 21386 MW; E112AF32AD6A5C80 CRC64;
MLAFLHRILD WFKNVFWKEE MELALVGLQN SGKTTFVNVI AAGEFSEDMI PTVGFNMRTV
TKGNVTIKIW DIGGQPRFRS MWERYCRGVN AIVYMVDASD LDRIEASKNE LHNLLTKPQL
IGIPVLVLGN KRDVPNSLDE KDMIERMSLS VFQDREICCY SISCREKDNI DITLQWLIQH
SKSKR
//
