ID T1ELT5_HELRO Unreviewed; 396 AA.
AC T1ELT5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=Cytohesin 1 {ECO:0008006|Google:ProtNLM};
GN Name=20197535 {ECO:0000313|EnsemblMetazoa:HelroP156254};
GN ORFNames=HELRODRAFT_156254 {ECO:0000313|EMBL:ESO11902.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP156254, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO11902.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP156254}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01002621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095812; ESO11902.1; -; Genomic_DNA.
DR RefSeq; XP_009010390.1; XM_009012142.1.
DR AlphaFoldDB; T1ELT5; -.
DR STRING; 6412.T1ELT5; -.
DR EnsemblMetazoa; HelroT156254; HelroP156254; HelroG156254.
DR GeneID; 20197535; -.
DR KEGG; hro:HELRODRAFT_156254; -.
DR CTD; 20197535; -.
DR eggNOG; KOG0930; Eukaryota.
DR HOGENOM; CLU_032820_3_0_1; -.
DR InParanoid; T1ELT5; -.
DR OMA; IPDNKDR; -.
DR OrthoDB; 204547at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro.
DR CDD; cd01252; PH_GRP1-like; 1.
DR CDD; cd00171; Sec7; 1.
DR Gene3D; 1.10.220.20; -; 1.
DR Gene3D; 1.10.1000.11; Arf Nucleotide-binding Site Opener,domain 2; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR023394; Sec7_C_sf.
DR InterPro; IPR000904; Sec7_dom.
DR InterPro; IPR035999; Sec7_dom_sf.
DR PANTHER; PTHR10663; GUANYL-NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR10663:SF406; MIP16918P; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF01369; Sec7; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00222; Sec7; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF48425; Sec7 domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50190; SEC7; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 56..246
FT /note="SEC7"
FT /evidence="ECO:0000259|PROSITE:PS50190"
FT DOMAIN 264..378
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 28..55
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 396 AA; 46198 MW; 698DC575ED7CF459 CRC64;
MLDDDITIPY RDLNDDEKAL LAKICWRKQL LLHDIQQIKD EISQVINEIE AFENTEAERE
NPQEKYLSIG RKKFNMDPKK GIQYLIEHNL LENNAQSIAH FLFKGDGLNK TAIGNYLGER
DELNIQVLKS FVMLNDFCGM ILVQALRQFL WSFRLPGEAQ KIDRMMEMFA QRYFDQNPAI
FKTTGYHDTC YVLSFAIIML NTCLHNPSVK DKPTVERFIA MNRGINEGGD LPQELLESLY
ESIKNEPFKI PEDDGNDLMH TFFNPVKEGW LWKQGGRVKS WKHRWFILND NCLYYFEFTT
DKEPKGIIPL ENVQVREVTS NHRPYCFEIH STGSEVIKAC KTDSEGKVVE GNHSVYKMSA
ISVEDRDDWI RSLRACVSDN PLYEMLATRR RKATKQ
//
