ID T1EM47_HELRO Unreviewed; 211 AA.
AC T1EM47;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Rap-GAP domain-containing protein {ECO:0000259|PROSITE:PS50085};
GN Name=20197647 {ECO:0000313|EnsemblMetazoa:HelroP156995};
GN ORFNames=HELRODRAFT_156995 {ECO:0000313|EMBL:ESO04374.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP156995, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO04374.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP156995}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01004334; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01004335; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096502; ESO04374.1; -; Genomic_DNA.
DR RefSeq; XP_009017643.1; XM_009019395.1.
DR AlphaFoldDB; T1EM47; -.
DR STRING; 6412.T1EM47; -.
DR EnsemblMetazoa; HelroT156995; HelroP156995; HelroG156995.
DR GeneID; 20197647; -.
DR KEGG; hro:HELRODRAFT_156995; -.
DR CTD; 20197647; -.
DR eggNOG; KOG3686; Eukaryota.
DR HOGENOM; CLU_1170316_0_0_1; -.
DR InParanoid; T1EM47; -.
DR OMA; EGIMGQE; -.
DR OrthoDB; 21929at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR PANTHER; PTHR10063:SF11; RHO GTPASE-ACTIVATING PROTEIN CG5521-RELATED; 1.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 15..211
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
SQ SEQUENCE 211 AA; 24036 MW; DD3F0A7153C580AC CRC64;
MIDSLKKNEK LVRELKHLDN QKCRETHKIA LIYVGLNQED KLSILSNKQG SPAYEAFLQA
LGWKVDLKSH MGFSGGLQAN GSNGAFAPYN ASSNNEIIFH VATMMPGDGE EEQLRKLRHL
GNDEVHIIWS EHIREYRHGI IPTEFGDVLL IIYPLECGLY RVQIKQKSKN YYFGPLYDET
VVDSIKLPGL IKHTAVNASR SLHLQENFYE P
//
