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Database: UniProt
Entry: T1EMB1_HELRO
LinkDB: T1EMB1_HELRO
Original site: T1EMB1_HELRO 
ID   T1EMB1_HELRO            Unreviewed;       367 AA.
AC   T1EMB1;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   16-OCT-2019, entry version 35.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESO00025.1, ECO:0000313|EnsemblMetazoa:HelroP157415};
GN   Name=20197711 {ECO:0000313|EnsemblMetazoa:HelroP157415};
GN   ORFNames=HELRODRAFT_157415 {ECO:0000313|EMBL:ESO00025.1};
OS   Helobdella robusta (Californian leech).
OC   Eukaryota; Metazoa; Lophotrochozoa; Annelida; Clitellata; Hirudinea;
OC   Hirudinida; Glossiphoniiformes; Glossiphoniidae; Helobdella.
OX   NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP157415, ECO:0000313|Proteomes:UP000015101};
RN   [1] {ECO:0000313|EnsemblMetazoa:HelroP157415, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RA   Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Simakov O., Marletaz F.,
RA   Cho S.-J., Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T.,
RA   Lv J., Arendt D., Savage R., Osoegawa K., de Jong P., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESO00025.1, ECO:0000313|EnsemblMetazoa:HelroP157415, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H.,
RA   Aerts A., Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V.,
RA   Lindberg D.R., Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
RN   [3] {ECO:0000313|EnsemblMetazoa:HelroP157415}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
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DR   EMBL; AMQM01005624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AMQM01005625; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KB097026; ESO00025.1; -; Genomic_DNA.
DR   RefSeq; XP_009021799.1; XM_009023551.1.
DR   STRING; 6412.HelroP157415; -.
DR   EnsemblMetazoa; HelroT157415; HelroP157415; HelroG157415.
DR   GeneID; 20197711; -.
DR   KEGG; hro:HELRODRAFT_157415; -.
DR   CTD; 20197711; -.
DR   OMA; ICKNRLV; -.
DR   OrthoDB; 956263at2759; -.
DR   Proteomes; UP000015101; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IBA:GO_Central.
DR   GO; GO:1990573; P:potassium ion import across plasma membrane; IBA:GO_Central.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   PIRSF; PIRSF005465; GIRK_kir; 1.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000015101};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     52     73       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    135    159       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       15    164       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      171    341       IRK_C. {ECO:0000259|Pfam:PF17655}.
SQ   SEQUENCE   367 AA;  42320 MW;  24E738DC14343801 CRC64;
     MRGRLFAGRR TERLIEKDGS CSVVSKNVSY SQNSFYRDIF TSLLDMRWRY NMVVFVFVFV
     GSWFFFAMLW WMVAFFHGDL PNDKVTTQRS TNDGMINVPC VDGVNNFLTA LLFSVETQQT
     VGYGTRNLNS HCTSATILLV VQACMGILLQ SLMTGVVYSK LSRPKHRART MMFSKFAVIC
     QRDDQYCLLF RVGDTRKSYL IGTSIRVLLI KSKDECSFFS NFQHSLDLEM DQDAHDSSIL
     LIWPVTVVHK IDENSPLWNV SVEDLFTAKF EIVVVLQGTI EHTGMTAQLC TSYLPSEILW
     GHRLAPLLTY QNENGKYEIE FSEFHKVIPD KNMPECSARD RGKEVFLSKL KWSILPRMIL
     CMYKYCV
//
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