ID T1EMH1_HELRO Unreviewed; 205 AA.
AC T1EMH1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=HMG box domain-containing protein {ECO:0000259|PROSITE:PS50118};
GN Name=20197771 {ECO:0000313|EnsemblMetazoa:HelroP157878};
GN ORFNames=HELRODRAFT_157878 {ECO:0000313|EMBL:ESN93406.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP157878, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN93406.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP157878}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01007415; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097612; ESN93406.1; -; Genomic_DNA.
DR RefSeq; XP_009028475.1; XM_009030227.1.
DR AlphaFoldDB; T1EMH1; -.
DR STRING; 6412.T1EMH1; -.
DR EnsemblMetazoa; HelroT157878; HelroP157878; HelroG157878.
DR GeneID; 20197771; -.
DR KEGG; hro:HELRODRAFT_157878; -.
DR CTD; 20197771; -.
DR eggNOG; KOG0381; Eukaryota.
DR HOGENOM; CLU_082854_0_1_1; -.
DR InParanoid; T1EMH1; -.
DR OMA; REMIEYK; -.
DR OrthoDB; 1222485at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0008301; F:DNA binding, bending; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd21978; HMG-box_HMGB_rpt1; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 2.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR48112; HIGH MOBILITY GROUP PROTEIN DSP1; 1.
DR PANTHER; PTHR48112:SF32; HIGH MOBILITY GROUP PROTEIN DSP1; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF09011; HMG_box_2; 1.
DR PRINTS; PR00886; HIGHMOBLTY12.
DR SMART; SM00398; HMG; 2.
DR SUPFAM; SSF47095; HMG-box; 2.
DR PROSITE; PS50118; HMG_BOX_2; 2.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Nucleus {ECO:0000256|PROSITE-ProRule:PRU00267};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 8..78
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DOMAIN 96..162
FT /note="HMG box"
FT /evidence="ECO:0000259|PROSITE:PS50118"
FT DNA_BIND 8..78
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT DNA_BIND 96..162
FT /note="HMG box"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT REGION 54..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 162..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..72
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 162..185
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..205
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 205 AA; 23551 MW; 3FB7DE9B385A281C CRC64;
MGKTEGKPKG KMSSYAFFVQ TCREEHKKKH PGEQVVFAEF SKKCSEKWKA MSAKEKKKFE
EMASRDKTRF ENETANSSGG KGARGGKKKK KDPNAPKRNL SAFFFFCNEE RSKVKSQHPS
YTVGEVAKEL GKKWEVCEDK SKYDAMAVKD KARYEKEIAA YRSGEDVKKP KTAVPSKRKK
KEEDDDDEED DKDDDDEEEE EDESD
//
