ID T1ENU5_HELRO Unreviewed; 1050 AA.
AC T1ENU5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
GN Name=20198245 {ECO:0000313|EnsemblMetazoa:HelroP159291};
GN ORFNames=HELRODRAFT_159291 {ECO:0000313|EMBL:ESO12705.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP159291, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO12705.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP159291}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01000218; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095811; ESO12705.1; -; Genomic_DNA.
DR RefSeq; XP_009009425.1; XM_009011177.1.
DR AlphaFoldDB; T1ENU5; -.
DR EnsemblMetazoa; HelroT159291; HelroP159291; HelroG159291.
DR GeneID; 20198245; -.
DR KEGG; hro:HELRODRAFT_159291; -.
DR CTD; 20198245; -.
DR eggNOG; ENOG502QVM0; Eukaryota.
DR HOGENOM; CLU_006480_5_1_1; -.
DR InParanoid; T1ENU5; -.
DR OMA; HICDNDI; -.
DR OrthoDB; 2998146at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007155; P:cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 7.
DR Gene3D; 2.60.40.60; Cadherins; 7.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028:SF146; CADHERIN FAMILY; 1.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR Pfam; PF00028; Cadherin; 5.
DR Pfam; PF08266; Cadherin_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 7.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 3.
DR PROSITE; PS50268; CADHERIN_2; 7.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 870..903
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..146
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 147..262
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 263..372
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 412..522
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 523..625
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 626..732
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 736..852
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 1050 AA; 117829 MW; 1E9416E875976CB8 CRC64;
MVTLQKIIIV VAQTFLLDQR QRSASAARDS NTIKYDLYEE LPFNTTVGRL AEDANITSMY
DKHTLGRLNY YFLRADSVVA KFFRVDNKTG VLSTSDVRLD RDCAELCRRK ETCMLSLDVV
VQPVEYFQII KVRVELLDLN DNAPTFRESH ILLSINEASP IGSSYLLPAA VDDDSPKYGI
QRYEIESGTE KLGLVFSTSP SLQLEAKLVL RSVLDRELEA RYQVVLRAID GGTHAVEGLS
SLTGSIVIDI IVADHNDNKP VFDQSKYDIT VSEDTPVNSV VLKVSATDAD DGLNGQIEYL
LVGDSSHHQP HDMLISVNNH TGQVVLTAKL DREKTSIYQL RVLARDRGSD PLTSEVELII
RVADANDNKP SISVTFLQEQ YNNNNNNNIH NLNRNFNVNI FNSKLFAFSK KDNKLVSTDL
PEDAKTGSFV GHVSVKDPDE GNSGSVDCRL HDSGVNGIPT FLLQNTTFAG EYRIVLSGPL
DRELNSVFML NLSCRDRGQP PLTSEMMLEI NVKDINDNPP IFDKPLYKVS LSENNFIGEV
VEQVTAKDAD EGLNGKIDYA LSEHAKGFFQ IDERGLISAI VPLDRETNSV FEMDVVARDR
GVPSLTSTSH LTIIVDDLND EKPTFTHSTY SFSIFENEPV GTAIGTVKAI DRDSNQFNEF
TYRMYSDHQQ SSRYFSVHPN TGVISSRIIF DREQHNLYKF YVTSVDAHLD VLSGSTVVIC
SILDRNDNYP EFKYPTPTNN TLHVSSYYPI GQPIVKVEAV DKDINANGQI KYRIVSIESN
DDSDDEDEMN EELDDEDENA LKYFPFQIDT TTGAIKVAKD LTLYNNLFKL NIEATDLGTP
PNFRQAELNI RVNSSLPYGS SSKQTKNESL FTLGGAFTLV FVIILTSISF VVIVSILVCL
VLCRQHRKNQ NQKSKHKTRL SLISVTCDGE YELTRPFSNK DSITMSQNCN SKLNLPYLET
TELAATDDNF IVESNIGNVP NVRCSSVKFG KKYLPVEQDP IGLNSEYSPN ESQQHQIIPQ
TNHNKLFVSR KKKEHKNRRA LINYVLLVFL
//
