ID T1ENW0_HELRO Unreviewed; 714 AA.
AC T1ENW0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE RecName: Full=FERM domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20198260 {ECO:0000313|EnsemblMetazoa:HelroP159320};
GN ORFNames=HELRODRAFT_159320 {ECO:0000313|EMBL:ESO12737.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP159320, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO12737.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP159320}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01000223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095811; ESO12737.1; -; Genomic_DNA.
DR RefSeq; XP_009009457.1; XM_009011209.1.
DR AlphaFoldDB; T1ENW0; -.
DR EnsemblMetazoa; HelroT159320; HelroP159320; HelroG159320.
DR GeneID; 20198260; -.
DR KEGG; hro:HELRODRAFT_159320; -.
DR CTD; 20198260; -.
DR eggNOG; KOG0248; Eukaryota.
DR HOGENOM; CLU_386969_0_0_1; -.
DR InParanoid; T1ENW0; -.
DR OMA; LTANTHH; -.
DR OrthoDB; 4538469at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005856; C:cytoskeleton; IEA:InterPro.
DR CDD; cd14473; FERM_B-lobe; 1.
DR CDD; cd17094; FERM_F1_Max1_like; 1.
DR Gene3D; 1.20.80.10; -; 1.
DR Gene3D; 1.25.40.530; MyTH4 domain; 1.
DR InterPro; IPR019749; Band_41_domain.
DR InterPro; IPR014352; FERM/acyl-CoA-bd_prot_sf.
DR InterPro; IPR035963; FERM_2.
DR InterPro; IPR019748; FERM_central.
DR InterPro; IPR000299; FERM_domain.
DR InterPro; IPR000857; MyTH4_dom.
DR InterPro; IPR038185; MyTH4_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR22903:SF8; MAX-1A; 1.
DR PANTHER; PTHR22903; PLEKHH PROTEIN; 1.
DR Pfam; PF00373; FERM_M; 1.
DR Pfam; PF00784; MyTH4; 1.
DR SMART; SM00295; B41; 1.
DR SMART; SM00139; MyTH4; 1.
DR SUPFAM; SSF47031; Second domain of FERM; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50057; FERM_3; 1.
DR PROSITE; PS51016; MYTH4; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 174..379
FT /note="MyTH4"
FT /evidence="ECO:0000259|PROSITE:PS51016"
FT DOMAIN 390..714
FT /note="FERM"
FT /evidence="ECO:0000259|PROSITE:PS50057"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 714 AA; 80150 MW; 0CCFB6230073868C CRC64;
MAIYSHHPLH HHRKSNEFSS GRKTGDDVDG DVGSDNNDDS LMIILWPSLP ASTLQRPSSG
LSPVYLNIHK SSNDVQWYHS LLKTAALRRN SSSNITSSVS NIQLTPSKFS ATSVRQHSDF
EKLVHNLLLS TDGHLSSFAS AASTSASSSS PATTTRSTTT TTAHALWKDP LLLPSKQPLT
HSILTMHNPE LEKVARDIFD TILKFMLLPL DSIDMDKKVG LVQSIFELCI RNHQCLKDEL
YCQLIKQTAH VVSHIQSQQQ HHKTLGTLLC GGHHWFLCDS SPTSPLNSTI ESSDLKLTSP
NSQSESSIQA WQLLAMAIPL FLPARCSIRW LLRTYLQRSS DSKSESGKFA SFCERAVERT
MKNGPRCHPP SHLEVISVLS HNPYHHSQPI SIPIHLPNNS YQVVSFDGST TILELLKTLN
EQLNMRSHTQ SGYALFACNS NAQEQLICCH DYKTKICDVL SFLEAKFNMN SKSKHDRNPV
KLIYKNRLPY VTLSEHDCFR LYMRHNLQHE TSKEMLLCCY QLNEQICSAF MPISWSLAVE
LAALMAQIEF GDIKISSDVK PAKTSSTSSS SSSSSHLIIL AQVIERFFPQ HLLSEYSADV
KKNRDSMESR LVDSWFKLRG KASSDCVRVY LTVLRRWEFT GAAMMHVKSI RSEGGGVEDV
ILGVHCDGVC VLHCKTLSIV ITFVLPCDLI FIFLQTPFLH RQQKPSSRDY QLDG
//
