ID T1EPP4_HELRO Unreviewed; 463 AA.
AC T1EPP4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=G-protein coupled receptors family 1 profile domain-containing protein {ECO:0000259|PROSITE:PS50262};
GN Name=20198544 {ECO:0000313|EnsemblMetazoa:HelroP160033};
GN ORFNames=HELRODRAFT_160033 {ECO:0000313|EMBL:ESO05935.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP160033, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO05935.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP160033}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01000471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01000472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096324; ESO05935.1; -; Genomic_DNA.
DR RefSeq; XP_009015303.1; XM_009017055.1.
DR AlphaFoldDB; T1EPP4; -.
DR STRING; 6412.T1EPP4; -.
DR EnsemblMetazoa; HelroT160033; HelroP160033; HelroG160033.
DR GeneID; 20198544; -.
DR KEGG; hro:HELRODRAFT_160033; -.
DR CTD; 20198544; -.
DR eggNOG; ENOG502RFAV; Eukaryota.
DR HOGENOM; CLU_590908_0_0_1; -.
DR InParanoid; T1EPP4; -.
DR OrthoDB; 2876007at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0008528; F:G protein-coupled peptide receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR019427; 7TM_GPCR_serpentine_rcpt_Srw.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR PANTHER; PTHR46273:SF4; AT19640P; 1.
DR PANTHER; PTHR46273; MYOSUPPRESSIN RECEPTOR 1, ISOFORM B-RELATED; 1.
DR Pfam; PF10324; 7TM_GPCR_Srw; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 67..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 367..387
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 407..426
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 287..423
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
FT REGION 244..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 463 AA; 50088 MW; 5A4AC0D61F18C242 CRC64;
MRIIVTSLFP SEIHSSVFPV IPLASYVKAK RLCGTLAKAL AKSKYISVSF PQRGAIWCTK
KRSKVSIFLV IATTLVTTFL NLATLTIKVQ FPSNCTLLYL NGSLVPTNDN IVSDTDANDL
ICIILPDDNS NDDDSGGDSV GGGGGGGGVS LGIRDNIAIG CEILCDWNAT DSCQCSESLG
NLTLASHSMM TSSSSSSSLS LHSLSSSSSS SSSSSTSPSQ TREKMISIII DDSNFDELTS
PQLSTLLHPR SGSPEATTTT ATTTTTTATT TATVTSANFK TSTGPEIMLT NLNFWVQAVL
VKIIPCIGMV ILSLLLKRKM TSAQRKRRQL LRAAMSDRNK DEQSRTLGAK KPGLDARQRR
TYRTTRMLII VVFLFAMIEF PNGLLNLLSG ILDDTFVKDI YDKLGDVMDL LTMVNSSINF
ILYCSMSRQF RKTFVSTFVT PLTPKKLLQQ RDAPTAAVKT CNL
//
