ID T1EQD3_HELRO Unreviewed; 283 AA.
AC T1EQD3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESO06365.1, ECO:0000313|EnsemblMetazoa:HelroP160532};
GN Name=20198783 {ECO:0000313|EnsemblMetazoa:HelroP160532};
GN ORFNames=HELRODRAFT_160532 {ECO:0000313|EMBL:ESO06365.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP160532, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO06365.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP160532}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR EMBL; AMQM01000617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096324; ESO06365.1; -; Genomic_DNA.
DR RefSeq; XP_009015733.1; XM_009017485.1.
DR AlphaFoldDB; T1EQD3; -.
DR EnsemblMetazoa; HelroT160532; HelroP160532; HelroG160532.
DR GeneID; 20198783; -.
DR KEGG; hro:HELRODRAFT_160532; -.
DR CTD; 20198783; -.
DR eggNOG; ENOG502SD1C; Eukaryota.
DR HOGENOM; CLU_984405_0_0_1; -.
DR InParanoid; T1EQD3; -.
DR OrthoDB; 2963156at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005272; F:sodium channel activity; IEA:UniProtKB-KW.
DR InterPro; IPR016187; CTDL_fold.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR PANTHER; PTHR11690:SF248; DEGENERIN-LIKE PROTEIN UNC-105; 1.
DR Pfam; PF00858; ASC; 1.
DR SUPFAM; SSF56436; C-type lectin-like; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 126..144
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 183..207
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 283 AA; 32332 MW; 699BF8CB7EB1C552 CRC64;
MEEPVKPHPS YPVQHIQKPT PRPDFLYPQQ YNQHDKTNQV FMEFPSKSFM KNEIKKQFSP
TKSSTKPNLP SGLGSFSNYY QFMSETIDEQ GPYRMMVFND FMTANLNTTA HGIPNYARAN
GKFKKMFWGL TILLMTSGMV FNIYELTQRY MDRPKQVTLS ITRNDALNFP SVTICNMNPV
KKSALDGQRN TSSNGNRGSS NDGSSTNAQD CPENWLYYSN YCYGEFSLSA SWHVANSTCV
RKHTCTLCMH AQAPHHTGMM VIEFRTDSIR TMLKTPYLAL LPA
//
