ID T1EQW3_HELRO Unreviewed; 1401 AA.
AC T1EQW3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=C-terminal of Roc (COR) domain-containing protein {ECO:0000259|Pfam:PF16095};
GN Name=20198963 {ECO:0000313|EnsemblMetazoa:HelroP160944};
GN ORFNames=HELRODRAFT_160944 {ECO:0000313|EMBL:ESO01782.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP160944, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO01782.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP160944}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01000715; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096742; ESO01782.1; -; Genomic_DNA.
DR RefSeq; XP_009019190.1; XM_009020942.1.
DR STRING; 6412.T1EQW3; -.
DR EnsemblMetazoa; HelroT160944; HelroP160944; HelroG160944.
DR GeneID; 20198963; -.
DR KEGG; hro:HELRODRAFT_160944; -.
DR CTD; 20198963; -.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_254306_0_0_1; -.
DR InParanoid; T1EQW3; -.
DR OMA; RIENIAW; -.
DR OrthoDB; 2942035at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0009966; P:regulation of signal transduction; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR CDD; cd00882; Ras_like_GTPase; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR032171; COR.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR45752:SF199; LEUCINE-RICH REPEAT PROTEIN SOC-2 HOMOLOG; 1.
DR PANTHER; PTHR45752; LEUCINE-RICH REPEAT-CONTAINING; 1.
DR Pfam; PF16095; COR; 1.
DR Pfam; PF00560; LRR_1; 1.
DR SMART; SM00369; LRR_TYP; 3.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51450; LRR; 2.
PE 4: Predicted;
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 693..891
FT /note="C-terminal of Roc (COR)"
FT /evidence="ECO:0000259|Pfam:PF16095"
FT REGION 120..166
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1040..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..149
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1401 AA; 159054 MW; F1F845CACD79C4B8 CRC64;
MRAYDHAHAC LNNVIMLPEC SVLEDIHRTP CDSDTTLAKR RSFADQYVLL VRQDATDFLE
NTFSNTTPEL VKDLIVLQDE RLPSITSLLS RIEHSTLTSL YIIDCWLRWT DEAVNNNENN
ATFPNNTGFS SNTGYTSNTL TTSNNPCVDS SQMPPPPPPP YRTSLHHHHH HHHIFSNVFA
TCNLRFLVLS YTHLTRLPES LFKMTALEIL KVDHNNLEEI PSEIGQLINL KTFCCDSQRP
RLRSLPASIT RLQRLEILSF SNNRIENIAW IVSMPTLRVL KCDRNHITRL PAHLVSLKLT
TLDISHNRIE YIPPTLVEMF CHLYHLEYFN LTLRPKHIQH DRSQLFSHLE MEHYLQTLQQ
QQQLQQQQQQ QPQPPYQQQA NQQYCNTRLG RDITIAVVGE THSGKSSLIE ALKDDKGISR
GIMESNKTSS ISTLLTRGHT GFESHQFDMR TSDGFTNCHV SVMAMGNEIF DNYSKNLKVD
FFILTFDMTS LEMHNGSQHL FARHVSRLQM WLQALYELSP ETPVLLVGTH AELVRSSSSV
TEIWNIVESL LDQARQHHAK RYGDNRCQFC LICNPKTSGR QTGQGRNRIA VSGAGFVDLS
SPHFDAPSIV NGHQQIDSNQ SNLPTQSSNQ NNMFLTSTIK IHHTRYSHIA GYYEVDSKKP
FPKDSKKANA SIDQLKVAIV RLANHQNKQQ LVPLTWLAFV RHLTTIREQS SGISSLSYEE
IISIARSFEI SPQQVPVMLQ YFHERGNVVY FPNNPSLSRL VVINPAWFVS MVKKALESFD
QSKSDTSRIL QCLSDKDLDR HLQKASGLTP NNTIVTSSGQ WLLAALQTLD LCLPVADCPA
TGDQILVFPN LLENGSPSQD VWPDVPEWDE KQITCDFRFR CLKPNQFIDF IRCINREGRV
LLEIVPDPVP VLLAHHIVFF TGIDLGGCDD CCNTRRKLRI SGSGTNGKQT SYYQQQQQQQ
QQQQQSQLLL QHSQQASVAS SCDEFDLMDD VMHKVHITLH SSMDAIRIQV RGVSPCCTMK
AVLNFLELYF DDIPDECPSN AAATDSSSSN ASDRASLNSQ SVSFSSESRG GSSSGGVTGH
QATVTSNMTG SGHHFFDDDD DRQFFLLCPK CVLLRHSKPE KIVYHQSSNV KRKAICNRWH
NLGSWTRAIT GDYRCSNTDI HLQTNLTSLP DYEHPRLVLV LPPSLAVSTK EWYMFSRVKF
LEGFEVHFLC ENPTYWHMTE NSGFRLQYTS TLRQSQRPPL GQLSKKSSHF SNQITTILGL
ALSMVQVVQG TNEHGQTCRL IAPVVADLIK MYDYLRNVDP HLTDSYAWLT KNKDRVVTML
TKVLANASDG LPDLYFKAGS SISTEMMFQS PSKANRNDLA KFLKVETTSG RFGQLRPLYV
GREIRWVCDA HYEELRTMPT K
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