ID T1ER53_HELRO Unreviewed; 285 AA.
AC T1ER53;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=VWFC domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20199053 {ECO:0000313|EnsemblMetazoa:HelroP161145};
GN ORFNames=HELRODRAFT_161145 {ECO:0000313|EMBL:ESO01939.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP161145, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO01939.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP161145}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the protease inhibitor I15 (antistasin) family.
CC {ECO:0000256|ARBA:ARBA00008768}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01000754; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096742; ESO01939.1; -; Genomic_DNA.
DR RefSeq; XP_009019347.1; XM_009021099.1.
DR AlphaFoldDB; T1ER53; -.
DR STRING; 6412.T1ER53; -.
DR EnsemblMetazoa; HelroT161145; HelroP161145; HelroG161145.
DR GeneID; 20199053; -.
DR KEGG; hro:HELRODRAFT_161145; -.
DR CTD; 20199053; -.
DR eggNOG; KOG1216; Eukaryota.
DR HOGENOM; CLU_977527_0_0_1; -.
DR InParanoid; T1ER53; -.
DR OrthoDB; 2946817at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0004867; F:serine-type endopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR Gene3D; 6.20.200.20; -; 1.
DR InterPro; IPR004094; Antistasin-like.
DR InterPro; IPR011061; Hirudin/antistatin.
DR InterPro; IPR001007; VWF_dom.
DR PANTHER; PTHR46439; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR PANTHER; PTHR46439:SF1; CYSTEINE-RICH MOTOR NEURON 1 PROTEIN; 1.
DR Pfam; PF02822; Antistasin; 2.
DR Pfam; PF00093; VWC; 1.
DR SMART; SM00214; VWC; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57262; Leech antihemostatic proteins; 1.
DR PROSITE; PS51252; ANTISTASIN; 2.
DR PROSITE; PS01208; VWFC_1; 1.
DR PROSITE; PS50184; VWFC_2; 1.
PE 3: Inferred from homology;
KW Protease inhibitor {ECO:0000256|ARBA:ARBA00022690};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Serine protease inhibitor {ECO:0000256|ARBA:ARBA00022900}.
FT DOMAIN 44..102
FT /note="VWFC"
FT /evidence="ECO:0000259|PROSITE:PS50184"
FT DOMAIN 206..232
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
FT DOMAIN 235..260
FT /note="Antistasin-like"
FT /evidence="ECO:0000259|PROSITE:PS51252"
SQ SEQUENCE 285 AA; 31727 MW; 86355DBFFB47301A CRC64;
MIEPCTRCKC KQWILSCSEV ACREPESCEW MALSSNDSCC KTCRGCFDDV VKRFFENGQT
WSQDNCTLCK CEAGVTHCFA EMCQTNCAHP REVPGQCCPV CDNKHEDEAL ADKSDRQPAY
ERSLAPLTQH ENIISTIGDT LDAQDNQDTM QPAAPCRLKC PFGFVKKNKV PVCICANDPK
TYKTKTTTSL NLLPTTLSEY PLIPACPKLN DCRLNCLYGR QVDDDGCFLC VCNLCPQLVC
NKKCLPGFQT NEDGCKICKC AVPTLNNHHT PNISPPNNKH SSFIV
//
