ID T1ERF9_HELRO Unreviewed; 297 AA.
AC T1ERF9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Etoposide-induced protein 2.4 homolog {ECO:0008006|Google:ProtNLM};
GN Name=20199159 {ECO:0000313|EnsemblMetazoa:HelroP161400};
GN ORFNames=HELRODRAFT_161400 {ECO:0000313|EMBL:ESO02163.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP161400, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO02163.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP161400}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the EI24 family.
CC {ECO:0000256|ARBA:ARBA00010970}.
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DR EMBL; AMQM01000810; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096742; ESO02163.1; -; Genomic_DNA.
DR RefSeq; XP_009019571.1; XM_009021323.1.
DR AlphaFoldDB; T1ERF9; -.
DR STRING; 6412.T1ERF9; -.
DR EnsemblMetazoa; HelroT161400; HelroP161400; HelroG161400.
DR GeneID; 20199159; -.
DR KEGG; hro:HELRODRAFT_161400; -.
DR CTD; 20199159; -.
DR eggNOG; KOG3966; Eukaryota.
DR HOGENOM; CLU_031164_0_1_1; -.
DR InParanoid; T1ERF9; -.
DR OMA; TVMQQRR; -.
DR OrthoDB; 315087at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
DR PANTHER; PTHR21389:SF0; ETOPOSIDE-INDUCED PROTEIN 2.4 HOMOLOG; 1.
DR PANTHER; PTHR21389; P53 INDUCED PROTEIN; 1.
DR Pfam; PF07264; EI24; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 84..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 204..227
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..265
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..288
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 36..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 297 AA; 34160 MW; 648AB2DC4895D36D CRC64;
MDQLVDFLRG VKDSLSGILA IIEIDKEEEK ALSAAGERVA QKPQRPPSVQ AMKRAANRNK
PSFDSKNSVD LKERETVFQR LRKCCLYNLI FALSVALLTD YVLSSCSELL PSFSLPEPVY
SIGSIIWWIS KSLYFAVGLF LLKVFNFFWC QDIADASYRK FRGRPKSLPL AMSYADLMFT
FCVQCIFILQ ANLVSYIFTT HFDGMFSFLA SVVYPYHMML LYTLYAYDYR WFFQGLEVQH
KFAYIEQHWP YFLGFGLPLY ILSNISESNI LNSSIFALCY PVFIVAANEA KTKPVKS
//
