ID T1ES16_HELRO Unreviewed; 4163 AA.
AC T1ES16;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESO02631.1, ECO:0000313|EnsemblMetazoa:HelroP161920};
GN Name=20199366 {ECO:0000313|EnsemblMetazoa:HelroP161920};
GN ORFNames=HELRODRAFT_161920 {ECO:0000313|EMBL:ESO02631.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP161920, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO02631.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP161920}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the filamin family.
CC {ECO:0000256|ARBA:ARBA00009238}.
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DR EMBL; AMQM01000972; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01000973; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01000974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096742; ESO02631.1; -; Genomic_DNA.
DR RefSeq; XP_009020039.1; XM_009021791.1.
DR STRING; 6412.T1ES16; -.
DR EnsemblMetazoa; HelroT161920; HelroP161920; HelroG161920.
DR GeneID; 20199366; -.
DR KEGG; hro:HELRODRAFT_161920; -.
DR CTD; 20199366; -.
DR eggNOG; KOG0518; Eukaryota.
DR HOGENOM; CLU_223933_0_0_1; -.
DR InParanoid; T1ES16; -.
DR OrthoDB; 2897437at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0030036; P:actin cytoskeleton organization; IEA:InterPro.
DR Gene3D; 2.60.40.10; Immunoglobulins; 36.
DR InterPro; IPR044801; Filamin.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR PANTHER; PTHR38537; JITTERBUG, ISOFORM N; 1.
DR PANTHER; PTHR38537:SF17; JITTERBUG, ISOFORM N; 1.
DR Pfam; PF00630; Filamin; 26.
DR SMART; SM00557; IG_FLMN; 32.
DR SUPFAM; SSF81296; E set domains; 36.
DR PROSITE; PS50194; FILAMIN_REPEAT; 38.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT REPEAT 27..106
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 116..199
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 197..294
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 409..431
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 423..506
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 504..599
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 596..652
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 648..743
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 757..833
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 840..893
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 904..983
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1054..1134
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1132..1245
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1253..1334
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1332..1428
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1442..1516
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1566..1618
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1616..1708
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1746..1804
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1814..1893
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 1939..2041
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2124..2208
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2256..2317
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2317..2410
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2424..2483
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2574..2656
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2703..2726
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2731..2862
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 2870..2961
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 3029..3119
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 3124..3217
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 3258..3349
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 3379..3403
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 3417..3508
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 3687..3777
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 3840..3928
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 3929..4023
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 4024..4120
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REGION 2506..2526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4163 AA; 448026 MW; 461B906B2EC902E2 CRC64;
MSGSINTDRD YRGCVYIPRA DGHHSHGENG QFSVVELPTF KVNANQKHSK VEVFVEDPTG
QTIKPYVKVV GDLYTSTFLP KMTGDYLVSM CVDGENIEGS PFYVKVFDPK LIRVLGLRGG
IVSQLNGFSV NTDGIGEGPM AITITHLGSN RIVPARIMQD PGRKSLFHVE WMPEEAGFYR
VNVQFARVDA DGSPYTIEVI NPSLSTISGL TSGQLISAGQ LNKFIIRVPS KMVVMNEMRV
DVTDPIGVRV PARLIDNNDG TVAVEFLPII IGSHVITASY FNMAISGSPF KVTSFDPAKV
KIINWKPLTF QRRAQVTLTL EFLEARPPTR SMRESMESIG SPLPPNNREL LNLDSRGPWT
CVVASAPTAA AFGNGVQPSP SLLINTPTFF EVKVQGSNED AHVDVVVKGC YSIEIKLDGV
PISGSPFTSR VYSPGSVILG EVKRGFVGRE VEFSVDASQA GDGSVEAVVD GGVYSVTFMP
KEAKVYNATV KFNGETVKGS PVSVNVLDLS KVTLVGGSGD LKVAVNKVCT LKLNTAGSGN
GQFTAIVRAP SGAEITPLIR EVNKKFLEIE YTPKEIGVYC VEVELEGMAL AVNPIQFSTY
NSSKIKGDLK FSVLGPNGGL LNNSVEQINS SNYSVVFTPL IQGQHQFTMS FNEEPVIATG
QTLRSFACNK MATFFITSPH VIRATDCDVK ITDPSLKNVS ARLSDMNDGT VRCDFTGAAP
GDYKIDVKCW GHSIPDSPFL SKASDVTKVT VTPILSALVG LNSSFNINVK DAGEGTLEIS
IQNPNGQQIP NSVAPLGPGQ FVVTFMPAIQ GTHHANVTFN EEPVKGSPFS IQVNDPTKCQ
VKGPKNLDVR SRISEQGPGV FKVEYTPLVP GDYVIDVEIF GKEVPNGPFT AKCWDHTKVK
CTKIASGRVG VQTSFNLDAS GAGEGDMEIV ISGPSRQNIA NHVTPLGPGL FVVTFTPEEG
GVHKVSVTFN QENVTGSPFI FNVIDLGRAS ARGDGLGAVK VNTNASFLIT APGAMEKDLE
LLIMEMKLNI SAWPYLGCPY YPKVWDSSKV LVTNVKNGRV GNVNVFNLDV TDAGEGTLEI
GVTSPSGQNI HNNVMPSGAG KFEVSCVPLE PGMYKISVTF NRENVVGSPY SFLATDMNKV
LARGDGLGGG RCGVATSFVV TAPAAQQKDV DIIVPTTFHF RAPAASGRDV HVKVTGPDYK
DIVPRVIENH DQYTVEFIPL KIGDHVIEVT YFGEMISCCP FVCKAYNASL VQLTPAGNGA
VNKASHFTVN TGQAGVGALD VVVTADGLAV PCVVKSMSSC LYDVSFTPQV CHSHDVCVKF
NGEEVPGSPL HVLVIDGSKA TAAGHGLELA KVNAVASFDV ITNNPPNINA KLEAHITNAK
GQFLPCKVTS TGPTSYHVEY VPKDAGCHKI ALTYAGSFIQ GSPYNVDAFD SNAIKISCCS
YGVVGKQYCF EVDTTKCGCL TGHLDVEVKG HLTKPITQVT SSRGVYTVNF VASENVSHNV
AVTYLGENCS PFSVKFIDPK NMHVNWDSVC HMPVNRAVTF DLVLGEVNMT SLINVPGNDL
MSAICRVRDP NGRELATRID RQTECFRIEF QPTMIGPHTI DLKFGGTTIV GSPHICNVYN
AAKVVITDAN IDNQLGRESC FTVDSSRAGD GYVEVKVICG EAEVITRAAQ IGDRIVKYSF
MPVQPKPHVA TVKFCSEPVQ GSPLTFQVIN PANKMTLSRT TPDKIGPLGQ PITALLLSDG
FMLNLADIKA EARGASSELL VTTLTSELDG TNKITFTPNC TGPAKLDVSY CGKAVSGSPL
IYDIFDACKV VAEIQNSGVV DQPVSFDVVL SKAGSAPLDI KITNGRNVSL PMTNQIVSYG
QRVTYIPKEA GLHVISIQYG CVDVPGSPFH QQIIDSFMPT AHGEGLENAI ENSPATFTLD
TRGHYGNLKV DVQGSPFQVH VTSPKKVQVV GGWESILDHH HHHMPLVVNE KKMFELDCSK
AGPGNLRVNV TGPDGVMPTE VHERADRRYH VGFTPRVEGN YTMKMYYNEQ PLERFPVLGT
AVRLLINQKA PPPCPVHYHH HQSHSHVHEQ EHQIKLAAVA HGQGLTSAKM LEEAEFFVVV
PDEKANSPFK VKVEPLVEVP ERPIIAMGYG IAMAEVNREA EFLLDGVDSD EQPKVIVSGP
VGEIPVYLTR FSPERYRCCY TPNRPGSYVL TVTHKNKHIT GSPFNVLVSG RDGVRNLPPT
AKNLQCGANG LAYNFNGVPY NVKYSNEICN PNPFLVVAMG PGLSRAVKNQ PAEFIVDTSA
SGPGDVTIQL TGPKEDVPVK IYQSADNIYQ CHVIPDQKAL NVKDVVVVGR GLCEGLVDEP
AEFIIDATQA GPGKPEVKIT EHKNEIPCKI SQVVTGIYKC TYVPPKEGEY HVFVLYGEVL
VPGAPYEVMV KNPPKEKPDK FMVVTGPGMS LAVVGQRAEF LLDGFEYDNL NMRLNCQNGM
DLPLQLFKIE PNKYICAYTP TVPVNVVEEM NLLPFPRPFN LKVKYENSDD DDDDDEEEED
KDGGFLGRFF NGGKKTKRMK KKKVVDARIV TTNLDPLQHF ADYSIHHKHC DQPVVVIGPG
KTEAVVNKMA EFIIDGAAGE PTIHLTGVEG DIEVQCSKLT SCRYHCSYIP QKEGVYLLNI
ATGGLNVPGC PFKVQVTNGS EPSLIVVAPE CPDGKNMIAV GPGLGTVYEK KTAEFIIDGT
DCEGVYLMNI QIKGVNIPGS PFKVTVLPED VPKPPSCAAV AVGEGLIFGS KNKRAEFVID
GVVAGEPMIL CQGPAGTYII HISVGGTPVC GSPFNVTVTD EDLEGPCYPE KVLVIGPGVS
FAVPGVTSEF IIDASAAGKG THTLSVAFNG KHIPGSPFKF ECMGQNVAVA GIGDASKVVA
IGPGLSGAQV NGLAEFLIDG CQDFTPMVQM YGSAMDVPVQ CVKIADGRFK CSYIPQASGV
HILIISVCGS QIPGSPFKVN VAENGPEVLL LQKPFATGQG LSVAQVGQRA EFMMEGVFNW
VYLMTVSCGD CQIIGSPFKV TVGCDEPPLQ PCPVKTAVAI GPGLSDANVG KTAEFLIDGA
CDSPEIKMIG LTGDLAVQSS IIGEDRYKCS YTPTAPGLYL LSISCCGFQL PGSPFKVVVP
PTVEEFHPSR TCVAIGPGLS QGCLDKISEF IIDGAGAAEN LQVQMVGRSG NEVLIRSLNM
GNGRYLCSYM PHIPGEYQLS VKSNNNHISG SPFRVLVTSE QDNFPARCPD PVFPPRNPPV
PPPSVVIVSP ETKEILNPEI LRPVCAIALG PGLTNATLHQ VAEFLIDGCF DDEPQVLLAG
VADNIPVHAM KIGEGRFKCA YTPEKPGVYL LSIACNGSQV IGSPFKIVVE DVKPPEVERK
TIVVSGLGTS CGSTSKSTKE GVYLLSISYQ GLQVPGSPFK VLVGSDDGRP CFDSDGKSCP
DACKPVAIGP GLTCAEMNSV AEFMLDGAGP TEPQIVMIGV NGEVPVKYVK LAEGRYKCAY
VPQAPGVYLL SITCHGNQIP GSPFKVTVHG APVFIERPQP IPIGVVQQPP LILQQPQHPQ
LILQQQQPQV IVRQQPVAMG QGLYLGQANQ MTEFVIDSCP DVPEIQMHGC DCEVFVRCFR
VDDCRYKCIY MLSLSIKGVQ IPGSPFKVVI QPDSKNPNIH QLPPLIVPAQ IVNTPIVVPM
HAGKVFAKPP KTDHGDSDDE DNESIAMKPT TFSSAVASGP GLMGAQLNDL AEFVVDGSRD
EPIAHMHGVD EEVAVRFHEV CDGRWKGSYL VSKPGTYSLT LITNGLQVKG CPFKISVHPP
VKATNADIYY KKKKQTIAKT VQRTTPESVA TTYTEFMSIV DEPEDSAPLP PRERIKPCIA
QNAIALGGGL TQAYCGKAAE FMVDCSNAGH GFLKAQLVGI TNAVDVHSTD IGEKRYVCSY
IPKVQGAYLL NVTWSDQPIP GSPFKVAVMS SVDPSKVTFS GDVFTNGGIV GQPINVMVDA
KNAGKDELKA TCKGPNKFTQ CKVEEVAEGL FNVSFTPEEP GPHLLHFLYA GVMIPNCPAT
IRIAGPIDPS KVVVTGKGVQ DGVLATFDNS FTVETKGAGP GQLTVRMRGR KDTFRIEMRR
DPMNNRTIHC RYNPTEVGLY ILDIKWSGQH VPGSPFKIHL FDSMMELNQF KRTGAIEGFA
ANRISELGKN DSIRSNGFDN EFD
//