ID T1ESR2_HELRO Unreviewed; 4019 AA.
AC T1ESR2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN Name=20199612 {ECO:0000313|EnsemblMetazoa:HelroP162498};
GN ORFNames=HELRODRAFT_162498 {ECO:0000313|EMBL:ESN99020.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP162498, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN99020.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP162498}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; AMQM01001098; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097143; ESN99020.1; -; Genomic_DNA.
DR RefSeq; XP_009022934.1; XM_009024686.1.
DR STRING; 6412.T1ESR2; -.
DR EnsemblMetazoa; HelroT162498; HelroP162498; HelroG162498.
DR GeneID; 20199612; -.
DR KEGG; hro:HELRODRAFT_162498; -.
DR CTD; 20199612; -.
DR eggNOG; KOG3595; Eukaryota.
DR HOGENOM; CLU_000038_9_1_1; -.
DR InParanoid; T1ESR2; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005858; C:axonemal dynein complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46532:SF4; DYNEIN HEAVY CHAIN 8, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR Pfam; PF12774; AAA_6; 2.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF08385; DHC_N1; 2.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 1887..2019
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2198..2353
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2529..2677
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 920..944
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1010..1036
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3130..3174
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3374..3415
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 921..937
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1012..1029
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4019 AA; 459843 MW; C6809299ACE93762 CRC64;
MLVLAFVSNE DEPVAGKCIV FCKSSASKLI TPGNVSEEVS MICFPSQQGD LLGPLHFIMS
NLFVQCLNHK QDLNKVQMSS DVQKFKSVLE DFTEKLPEFK DSVDDGIYLK RCDISDMLEQ
LTPMQYFEIA KDRKVVKESE DLLICWMDQI SRLLEECNRI RREEPDAGPH VELSHWKLRM
AKFAMLLEQL KSSHCKAVVH ILLANRSKYL TQWKDLDSKI TDGVNEAKDN VRYLEALKTN
FGHMKQCNPV EMQKMIPRLL NCAQLVYNVS SYYNTNERMT SLFSKLTNQM ITSCKLYMVT
CLSDKNRDSN NNSGSKGSTT SGSSNKEVVF VKRISTGSLE LIWNLKYSDV KSRIDNCVSL
YRTYKSKFNE IKEKLSANKE MKQFDFSENT IFGKFEMFVK RLQQLAVIRG WMHEFSPLQH
VNVDGVQVFI NKYQVILTSV RNIKYDVLDY RKQQFNRDYE NVKISFKTLS NQLNNFIDFS
LSRLSPIVKQ IQFLSNFTAF PAHHIDVNAK YLAVFDVYSH HLNSVLTSFE ENKSHPPRCR
NFPAMSSAMY WSDLLLMKIM KPMDLFKVIP GLLKMDGCVA TIRKFNKLAI DLVEYKQSKF
KEWATQVEEA MDCLKSPLLM TEDENLRVNL DVKVFELLLE VKHLRKMGMQ VPEAALLLSH
VEPRVKRLYE NLKCLTTIYN TTMNNISASM EFMFRPIRRR IDRLIAPGLR LITWTSVQID
QSPSFAKPWQ YGVDDVLFVV MSQKKLILSD ISKAYNAVAS FNNLCTMVRD MLESRIGSKL
DVVANTSCVA RMNVTMNVTQ FFNRNMEYLT NKQNEFSKIS SDIESNLNDT FELLMGHMSA
DEWKQFHELC VEDLDAYSVV VFSFAQKLQE AFIKCESHFK SLDQVVSFGE VGVVHQEISA
IKISLESLKN VLHGANGQLR MDDDEEEEEE EVRDEEVTKD ESYDGQKRTA YNGAVISVDV
TLSKFNNSIV LSTSIDDIQA CITKLLQNIT KMADRLIDWE ALKKVNEATK SEQNTDRLSS
STYKTPSGDS SGGPVARISR VLHDNSEISR LIVQLCSIIT NNRKSVSSFL SSFSTFNDLF
DETLDEKIEE FKNLCLLASE LPSTSTCDCL LLTLDNLKSC FMKEGHRKMM MYASVHNNQC
TLQLKPLVAY VHGASRKLDR PVKDLDDIRL LMSVITELRE KEVDVDHELL YLEETFLMFS
KYNLHFSDGN VESIDAASYQ WKLLKQKALL TQDNLLKIQP TYMKMLVANV HQYKQDLNVF
AQQYNSCFYA KDQQNLSPRE SLNKLTSFQF EFEQLWDKYV SYNGGEQLFG LPVTQFNQLI
ELKSDLDLKL LFFTLYNDVS KRLNELLESS WADVNIVEMM SDINAFYNKI VKLPPAVKTW
SEYEDLREMI NNYIEVQSLI EMMSAGPLAD NVWRQIFSLC GEVFEFNETN VMLMKDVIKL
PLLKFREDIE LTLTLNLQDV CITASREKDI AYKLKSLEDF WRSQKFDFST FKGKELLFKG
DSINETVTFI EDAMVLLSSL ISNRYSSSFR PRLQEMLSKL TVTMETIDKW MCVQNMWLYM
EAVFETRKFL NVDKTWQRLM QRAHEQNVIL DCCSTGESLS IMLTHLSDQL ESCQKSLSSY
LEKKRLLFPR FFFVSDPVLL EILGQASDPH TIQAHLLSVF DNTKSVTFDH RIYEKMLSLV
SQEGETVELT HPVLAVGHVE SWLNDLLVET RSTVHNSIKQ AHSVISEESF SFIDFLHQLP
AQVGLLCLQM IWTCDSENAL LNCKLNKKIM QTADGHFLEM LHQLIEVTTK DLKALERTKF
ETFITVHVHQ KDVFEELVIS QHVKSPFDFE WLKQCRFYYH DDEDECAVNL TDVKFRYMNE
YLGCSERLVI TPLTDRCYIS LAQALKMSLG AAPTGPAGTG KTETTKDMAR CLGKYVVVFN
CSDQMDYRGL GRIFKGLAQS GSWGCFDEFN RIELPVLSVA AQQISIVLSC KKDKKSQFLF
SDGDLVDMDS EFGIFITMLR QVGQKAEASM VKIVIGSCEK ICDWSIGPNN NGEMIRQSEH
GSVDKRTGAA MNRIIIIKVK LASAGFKQNI LLSRKFFSLY KLCEEQLSKQ VHYDFGLRNI
LSVLRTLGIV RRTDKERNEM VTLVRVLKSM NMSKLVNEDE PIFISLFNDL FPEVNQRESG
SHVIIENAVK NLVEQSPFLV QHEPWTTKII QLYETQNVRH GIVVLGPSGS GKSTCMQTLR
SALTDCGNLH KEVRMNPKAL TASQMFGRLD ASTNDWTDGI FSILWRKTHK TKKGENTWLV
LDGPVDAIWI ENLNSVLDDN KTLTLANGDR ISMSATCKII FEVQHLENAS PATVSRNGMV
YMSSAVMQWR IILEGWLKNK PLLKKRLLPL FEVCWDDIYK YVHWQLNEKL QVLECMYIAQ
AINIITGLLT DVTEQFSNNE MILKKLVTFA FVWSLGSLLE FDDRNKLEAY MKESLKEHLS
FPVAPGDGDD ESSSIFDWFV DDQGHWKHWN HLVPYFCFPS SPAFDFTNLI VPNANSTCIQ
YLINLIASQE KAVLLIGEQG SAKTSVIRNY CAGFDPEKRL FKNINFSCTT TPHSFQKSLE
SFMEKRMGAT HGPPAGKKMT LFIDDINMPL VNVWGDQVTN ETTRQLLESS GLYSLDRLGE
FIRIVDLQVL ACMCQPSGGR NDIPQRLKRH FSIFNCTLPS QTSIDKIFST IASGYFCKKN
GFADEVRELI ADLVPVTRKL WQEVKGSYLA TPAKFHYVFN LRDLSRIWQG MLRSKARVIR
GKKDLLSLWQ HECTRVICDR FTNDKDKQLF VNIMQKSLEA TDLLDASEAS NDVYFTNFMR
ETDESVENNE GKIYEPVESI DELQSKLTSY HQQYNELIRG SHINLVFFKN AVEHVVRILR
IIGLVRGHAL LVGVGGSGKR SLTKLATFIA GYNLFQISLT KSYNVNNLLD DFKTIHKMAG
LQDKSVCFMV TDSEIKDETF LEYFNDIMGP GEIPVLFTRE EKDEIQQNIL PLFKKYHPKQ
PTTNENLYEY FLSNVNKNLH IVLCFSPVGE KFRSRSMKFP SLISGCTMDW FERWPTDALL
SVAHHHLSTF NIVAAEEIKH SATCLMAVVH DSVAQICLEY FECYRRSCHV TPKSFLNFLK
TYKTLYSERF KNSNQLLDRM QTGLEKLEEA SESVNQLSEE LKMKEKELVV ATEEADKVMH
DVQTRAQAAE QVKGQVLAVM EKAQKIVNDI NIDKAKAELK LEAAKPALEA AEAALRTIHY
SHIASVRRLG RPPNLIMRIM DCVLLLFRLP ILPVSINMER LCPEPSWNEA LKLMAQANFL
QGLTNFPKDT INEETVELLQ PYLNMPDYNI ETATKVCGDV AGLASWTKAM AEFYVINKEV
LPLKANLAVH QAKHQLAIKD LDKARAELDE KQLELDKAQA LHNQAIKKKK ALLDDATSCK
KKMNNAKILI ESLAGEKERW VESSCTFKRQ IGQLVGDVLL AAGFLSYAGP FNQQYRSDML
RKWKNKLLSY NIPLSDDFNV TTMLADKLLV SEWTSQGLPN DELSIQNGLI VSSAGRYPLL
IDPQEQGRTW ICKKEAANQL IVSTFSEKHF RTHLETALTQ GRPLLIEDAS VDIDPVIDNV
LDHNFFKLGS IMKVKISDKE VDVIDGFKMY IATKHSNPSF TPEVQAKTSL IDFTVTSKGL
EDQLLGLVIL TEKKELESER LKLHEEIWQN NQKIKQLEDD LLQRLACTQT SLVEDDSLIE
VLKVTKLTAK EINNKLTIAA ATELRINQAR EEYRPVASRG SITYFLIVEM SLVNCMYQTS
LNQFLQLFYS SMKCAAKSLV VSKRVGSIVS ALTLSSFTYI TRGLYEKDKF LFSLLLALKI
GLQDGSVPHE LFHVFIKGGA ALDLNTVQAK PKKWISDVTW LNLVELSRLR FFNSLTMQVA
NNDKAWRDWY ESAEPEDVPF PEENLQKLST FNKLLLIRCW CPDRAVNMAK IYVSEVLGKQ
MNCKRICDKI QYVDGVAVDF ELMSQEATPL SPLVCLLSLG SDPTETIEKL AKSKNIGNF
//