ID T1EUD7_HELRO Unreviewed; 592 AA.
AC T1EUD7;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE RecName: Full=ETS domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20200187 {ECO:0000313|EnsemblMetazoa:HelroP163707};
GN ORFNames=HELRODRAFT_163707 {ECO:0000313|EMBL:ESN96619.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP163707, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN96619.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP163707}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU004019}.
CC -!- SIMILARITY: Belongs to the ETS family. {ECO:0000256|ARBA:ARBA00005562,
CC ECO:0000256|RuleBase:RU004019}.
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DR EMBL; AMQM01001438; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097495; ESN96619.1; -; Genomic_DNA.
DR RefSeq; XP_009025754.1; XM_009027506.1.
DR AlphaFoldDB; T1EUD7; -.
DR STRING; 6412.T1EUD7; -.
DR EnsemblMetazoa; HelroT163707; HelroP163707; HelroG163707.
DR GeneID; 20200187; -.
DR KEGG; hro:HELRODRAFT_163707; -.
DR CTD; 20200187; -.
DR eggNOG; KOG3806; Eukaryota.
DR HOGENOM; CLU_461001_0_0_1; -.
DR InParanoid; T1EUD7; -.
DR OrthoDB; 3915960at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000418; Ets_dom.
DR InterPro; IPR046328; ETS_fam.
DR InterPro; IPR024668; GABP_asu_N.
DR InterPro; IPR003118; Pointed_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11849; ETS; 1.
DR PANTHER; PTHR11849:SF195; GA-BINDING PROTEIN ALPHA CHAIN; 1.
DR Pfam; PF00178; Ets; 1.
DR Pfam; PF11620; GABP-alpha; 1.
DR Pfam; PF02198; SAM_PNT; 1.
DR PRINTS; PR00454; ETSDOMAIN.
DR SMART; SM00413; ETS; 1.
DR SMART; SM00251; SAM_PNT; 1.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00345; ETS_DOMAIN_1; 1.
DR PROSITE; PS50061; ETS_DOMAIN_3; 1.
DR PROSITE; PS51433; PNT; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004019};
KW Nucleus {ECO:0000256|RuleBase:RU004019};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 265..351
FT /note="PNT"
FT /evidence="ECO:0000259|PROSITE:PS51433"
FT DOMAIN 377..457
FT /note="ETS"
FT /evidence="ECO:0000259|PROSITE:PS50061"
FT REGION 77..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..114
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 592 AA; 67430 MW; C144E3ECEA0D8639 CRC64;
MYHAESLFIK VETPDDLNSI HDFLNVSASK DDGQFTLAAD VFKKHINGSA SEYSCDNNNN
SLYEGCNEHE FALNGLKNHD DQTNGHTNDN DENVSDNTGN DVSNINSTDS IIINDGDDNN
EDDDEDESLD QYFEPINLRI QQLDLSQPLW YIRDLLVSDG IIDGNVKKVE YWLQNNDKLD
ESKSLKWCCV EMEGENIQVN IDVRARLDNK KIRINISDIL VPCDETSTDQ VTTTIKPKRQ
RTVKTKPPPS VSNQALQSRQ FPNWSADPVF KTIQVANNIP TRLEDWTCDH VRLWLRWASS
HFPFDFDPHS DDINVTGVEV CQWQLKDAQV LAPRDVNNLF WTHIQLLKKL HIATLNDVQV
NPAMNNPSKG RGLNGQVQLW QFLLEILIDQ SHRHMVEWVG RDGEFHLINP EGVAQLWGCK
KNRTGMTYEK MSRAMRYYYD GDIIHKVPSK RFHYKFVCDL RSKVGFSVSE IQDLVNSPTA
AIESPDCVNS DRMKLQSLLE TLRSPACLRR AVPINTPMIN NGNYTNGTTA ASTTLSNDIS
NSSTFNNKNF RIVVATTEQL QTISPDLWLN LTTQQQQQIV ECVSHEQDVV SN
//
