ID T1EVN1_HELRO Unreviewed; 300 AA.
AC T1EVN1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=Endonuclease/exonuclease/phosphatase domain-containing protein {ECO:0000259|Pfam:PF03372};
GN Name=20200631 {ECO:0000313|EnsemblMetazoa:HelroP164616};
GN ORFNames=HELRODRAFT_164616 {ECO:0000313|EMBL:ESN92545.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP164616, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN92545.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP164616}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01001739; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097639; ESN92545.1; -; Genomic_DNA.
DR RefSeq; XP_009028882.1; XM_009030634.1.
DR AlphaFoldDB; T1EVN1; -.
DR STRING; 6412.T1EVN1; -.
DR EnsemblMetazoa; HelroT164616; HelroP164616; HelroG164616.
DR GeneID; 20200631; -.
DR KEGG; hro:HELRODRAFT_164616; -.
DR CTD; 20200631; -.
DR eggNOG; ENOG502S0A1; Eukaryota.
DR HOGENOM; CLU_000680_8_4_1; -.
DR InParanoid; T1EVN1; -.
DR OMA; HSMVHKG; -.
DR OrthoDB; 1214522at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008311; F:double-stranded DNA 3'-5' DNA exonuclease activity; IEA:InterPro.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd09076; L1-EN; 1.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR037493; ExoIII-like.
DR PANTHER; PTHR43250; EXODEOXYRIBONUCLEASE III; 1.
DR PANTHER; PTHR43250:SF2; EXODEOXYRIBONUCLEASE III; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 59..269
FT /note="Endonuclease/exonuclease/phosphatase"
FT /evidence="ECO:0000259|Pfam:PF03372"
SQ SEQUENCE 300 AA; 33464 MW; 92992049A9B1CB8F CRC64;
MALSIRQKRV RRISGDPVHG VVVQGPVDGL ATGTPLYSVA VQGTIDGRTT CRPRDWRFGT
WNVGTLTGRS LEVVEELQRR MVDVAALQEI RWKGEGTRFV EAKGGRYKLW WKGDDGTGGV
GVMVREELVE KVLEVRRRSN GVIVVVMVFG KVIVRVISGY APQQSRKEEE KDRFYDDVSD
EIGQAGLNEF VVLLGDLNGH VGADADGYEG VHGGWGYGIR NEEGRRVLEL AGAHSMVVGN
TWFTREPARL ITYRSGEHRS MIDYILVRAK QRKYVKNVKA IPGMLQHSMV HKGTSAIDYL
//
