ID T1EVU3_HELRO Unreviewed; 4660 AA.
AC T1EVU3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
GN Name=20200693 {ECO:0000313|EnsemblMetazoa:HelroP164811};
GN ORFNames=HELRODRAFT_164811 {ECO:0000313|EMBL:ESN92715.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP164811, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN92715.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP164811}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01001838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097639; ESN92715.1; -; Genomic_DNA.
DR RefSeq; XP_009029020.1; XM_009030772.1.
DR STRING; 6412.T1EVU3; -.
DR EnsemblMetazoa; HelroT164811; HelroP164811; HelroG164811.
DR GeneID; 20200693; -.
DR KEGG; hro:HELRODRAFT_164811; -.
DR CTD; 20200693; -.
DR eggNOG; KOG4475; Eukaryota.
DR HOGENOM; CLU_224156_0_0_1; -.
DR InParanoid; T1EVU3; -.
DR OMA; RIYRVQP; -.
DR OrthoDB; 2917340at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR Gene3D; 2.60.40.10; Immunoglobulins; 41.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR45080; CONTACTIN 5; 1.
DR PANTHER; PTHR45080:SF32; MYOTILIN; 1.
DR Pfam; PF07679; I-set; 40.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00409; IG; 39.
DR SMART; SM00408; IGc2; 38.
DR SUPFAM; SSF48726; Immunoglobulin; 41.
DR PROSITE; PS50835; IG_LIKE; 37.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 156..249
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 332..427
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 450..526
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 531..632
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 638..732
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 757..839
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 843..942
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 972..1085
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1097..1188
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1208..1293
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1303..1394
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1402..1492
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1516..1601
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1613..1710
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1716..1810
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1813..1918
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1941..2020
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2041..2118
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2130..2257
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2328..2432
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2452..2532
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2555..2667
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2850..2947
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2950..3050
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3070..3141
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3155..3251
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3277..3360
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3380..3459
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3575..3647
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3694..3780
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3795..3878
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3899..3981
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4001..4084
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4090..4186
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4194..4291
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4297..4394
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4406..4503
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 4660 AA; 515769 MW; 4801427AA87E114C CRC64;
MVILTEISNP ATPASHLLPE KRFATTITLA KKSVEPLPPR LTYKEIIFGN HDQNSKIYET
NVFWLPKKFL SASRQVEFNG MIDKQRSKNY VIVKKLTTTT TTNNSKLKSE RQICSHSHDN
AMQIYRNCNK RMLSVSIVLD RKKKRHRSSI FLYLQPRDAK QTIQLGDYLF LVTRISGQPA
PTVTWFRNNV PIKCDDYGNS TESDLQFKCS REDDDYLLFC ARPPALASGV YSCRAVNEFG
EALSQATVVI EDNVHIVTKE HQTYLTSHDV NIGKSKPAKE STENNSSKLT TWNENKMDTV
KVLKSQMIVR EDHLPTTLRI PPTPIISKVK APKFVEALKD VITYEDGDAT FHCVVSGSPK
PDVAWFINGA PLEFGGRIKV EELVLSEADF IIQQTISIHN VTKDDAADVS AVISNSAGRA
SASATLRIKS KSLKFLEKPN NVVTHVDGRV TFKCIVLGSP TPNIKWRING RPLKFDDRIA
KEETVGTDKN DVSIVQQTIV ITRVTSEDEG EVKVMASNLA GEIDASCMLI AKVKSIKFLQ
ELEDVTAFYD DSASLTCVVC GLPKPDIIWL LNGQPVFFDS RISLQEKINE DDDEVTVKQT
LVLKKVSLLD DGDVKVVAWN AANQISARAK LNVKIKSLKF LSRPSDVKAY HGDEAVFSCI
VSGFPRPDLK WHMNGQLMKF NERMYLKEEV GTSEEDDVSV LKQTIFIEEL IPTDGGEVQV
VATNQGGSVE ATCFLVVKEK FIKFLRKPAD CSVDIEDDVQ FSCIVSGSQQ PNVTWYHNGS
PMKFSDRIKQ QETVEEDNEG ASIVKQVVVV SEVTAEDEGE FQVVASSVAG RISASASLNV
KAKSLMFLER PADVTTYDDE NVAFACAISG YPRPNIDWFL NGKPITDDKR ISMDEKISSI
ERNLSTIRQT VAIKKVTVAD AGDVRVVASN SAGKVFSAAK LTVQACDKKL SIQHILTECE
KYNQIRRKLG VPSNVELLFQ NRKTKSLEFL NRPTDVVTYS GSSACISCVV SGSPKPVLRW
TLNKEPIEAN DRISLEENVV ADHDDGKHTV KHVVVIRKLR PEDSGEVGVD ASNSSGDIHA
SSLLTVKAML LEFLEKPKSL STYLKDCANF NCIVSGSPEP RVYWLINGKP VEFNERILIE
ETVETDANDV STITHKITIK KVSSEDVGEV QVVASNLIGK LIETCNLATK ATSLEFIEKP
KNQGTFLGED ATFSCVVSGA PRPQLHWLIN DGEVQFNDRI LIKETVDTDL NDVATVKQRV
TIKKVTEDDV GNVQVVATNL GGRISEVCNL KVKAKSLEFV EKPKNVTAYL DEGATFNCVV
SGSPKPDIQW LMNSEPVVFS DRILKKETVE TDLNDVSIVR QMVTIKRISP GDVGTIEVVA
SNFFGKLSES CRLTAKIIIT FPIVKSLEFL EKVKNVTTYF GEDASFSSAV SGSPRPDVHW
LINGRPVILD NRILIKETVD TDVDDVTRIK QKITIKNVKA EDGGEVQVVA SNLFGKLNDV
CNLIVKVKSL EIVEKPKNVT TFIEEDATFS CVVTGSPKPD VQWTINGRPV VSNDRILIEE
TVDTDANDVS TIKQKLTIKK VSSEDVGKVQ IAVSNLSGKL TEACDLKIKT KSLKFLKKPT
NARVYPDEEA TFSCAVSGSP KPDLHWLING KPVQFNDRIL MKETIDTDVN EVSTIKQRIT
IRKVIPEDGG NVQVVAYNIF SEISETCNLS VKENSISFVE KPVGVTVSDD DRAVFSCVVS
GYPKPNIFWT LPSREKMSIE DTTLDETVDT DEEGRFTIKQ VTTIKIKKVA MSGSSEVQIE
TSNSAGKLSC CAPFVVRAKS LKFVSEPSDV TTYIDENASY SCSVMGYPKP IVDWQLNGKQ
MTFSDRINME ESVIIDEKDT FVIKQAVVIN KIISADEGKV RVVASNSCGK IFSAAKLTLK
KKSLKFVEKP ADATCYNDGE VSFKCIVSGY PKPIINWTLS DRSIVKNDRI ALEETTNFDD
DVYTVKQVIT IKNVATTEAG KIRVVASNSV GNIYASSSMS VKGEKYLEFL EKPTNARSYF
GKDATFSCVV SGSPRPVLYW SINGKPLEFN DRIMIKETID TDTNDVSTVK HKITIKKLDP
KDLGEVQVVA SNLSGKLTEV CSLMNKMKLL EFVEKPENVS TLPDDEATLQ CVVLGSPKPD
VHWLLNGKAL RFNERILIKE TIDTDANEVT TIKQKIFFKK VSLKDGGEIQ VVASNLSGKL
VQTCSLAVKE KLLNILEIPS AVTACDNDFA TFTCTVSAYP RPDFDWLLRG NPMKFDERIV
KEETIDTNED GTFRIKQKIT INEVRSSDAG DIQVVVSNAA GKISKSAPLV VKVKSLKFLA
EPTDIRAYDG DNAPFSCFVS GYPKPELIWR VNGQLIKYNE RIELKEEIEE VEDVFVVKQR
IVIKNVAPTD EGEVQVVASN STGNSSASSS LIVKVASIEF LKKPTDLTTY FGDGASFECI
VSGLPMPNIQ WFINGSELKF DGRRTKKELI ETDTNDVFTV KQTVFINEVT TEDVGEVQVV
ASNSFKNTQT FCILKAKEKL IQFLEKPLSS FAYGGDEVKF NCVVMGHPKP SVEWLLHGRP
MKFSDRIKQH ETVEEDNEGA SIVKQVVVVS EVTAEDEGEL QIVASNLKGT LTATASLNVK
EKLLKFLERL VDATVYSDDD ATFTCVVLAS PKPLLNWHMN GKPLKSNDRI TIVEKVDINN
GDVSTIKQTV SMKKVSPNDA GEVQVVASNA AGNISTSSLL TVKVKSLKFL ESPNDVTAYA
DHNATFSAVV SGQPKPVLHW LLGGQPIKFS DRIILQESTG ADRNDVSIVQ QTIVITKVAR
EDEGEVKVVA SNLAGKIDSS CKLRVKVLSI KFLETPSNVT LCSGHRTSFG CIVSGYPKPD
VAWLHCGRPM KFSDRIKQQE TVEEDNEGAF IVKQVVVVRE VTAEDEGELQ VVASNLKGIL
TANASLNVKE KFLKFVRKPD EVTATEGDDV ELSCVVSGYP RPLINWLIDE KPVQYDNKIS
RKEQKVTDDE HACTIEQAIL IKKIAPTDSG KIQVVASNSS GEISTFSTLV VRAKSLKFCE
KPGDITAHIN QNATISCIVA GYPRPDIVWS LNDRPLKFSD RIILQESIET DRNDVSIVQQ
TIVITKVTAE DEGEVKVVAS NLVGKITAAC KLFAKEVTLE FLEGPTDKTA VDGDRVEFNC
SLSAYPRPDI IWQHRGRPME FSDRIKRQET VEEGNEGASI VKQVVVISEV TAEDEGVVEV
FASNSKEIVI SASALLNVKI KALNFLEEPL DVTSFNGDDA TFTCVVSGYP KPLINWHVNG
RKIKFSDKIT LEEKVDTSDE NVFAIKQTVV IKKITPSDAG EVQVVASNSS ASISSSSSLT
VKIKSLQFLE KPNDVSSFVG QCSTVSCVVS GYPKPNTKWL LNGQPLKFSD RILLQESMRI
EMNDITIVQQ TVVITKITAE DKGEVKVVAS NLAGDIDASC ILYVKDTSIN FLVKPVDMAV
ESGDDVDFIC VVSGFPRPDV KWFAWLQHGQ TIKLSDRVKL HETADLDEEG MFIIKHTATY
KNVTAEDAGE VQVVASSSAG KIFAIGKLEV KVKSLKFIQE PTNVTAYDDD DAVFICVVSG
YPRAFLEWQI NEKPIIYNDR INMEEKISTG DKYECTVKQT VVIKKITPSD AGEIQVVASN
SSGKLSKSSL LRVKVKSLKF LEKPGDMKVY TDHVATISCV LSGSPKPDLL WLLNGRPIKF
SDRIIMQEST DTDRNDLSII QQTIVITKVT TEDEGEVQVV ASNLAGKLDA SCKLIVKEMT
IMFMEKPIGL TVTLGSQATF ICKVSGLPKP DICWLYQGRL MKFSDRIKQQ ETVEEDNGGA
YIVKQVVVVS EVTAEDEGEF QVVASNLKGE ISARAILNVK VGSLKCLKKP NDVTAYKDDN
ATFSCIVSGH PKPIINWEIN GRPIKYDDRI SKEEKIVTGD EDVYTVEQTI VITKITPADA
GLVQVVASNS SGNISVSSIL TVHVKSLKFL EKPENVISFV GESATFGCSV SGLPRPDIRW
LLNGQAIELN DRISKQETTT IDQDNITVIR HAIVINKLTS ADEGKIQIVA SNLTGKIAAT
ATLNVKMKSL QFLKNPSDAT VYNDDYVAFN CLASGSPKPI IDWQINNNQI KTDDRIKVEE
KITNVRDEYI VEQTLIIKKV TVADAGRVEV VASNSYETIS TSCSLTVVVR VKSIQFVEKP
KDCLVDANNR AIFHCIISGY PKPDIKWLAN GRPIKFNDRI IKEETIVTDK NDVSIVHQTI
VITNVTADDE GEVQVVASNL AGDVAASCSL IAKRSSLEFL TKPSDLRVFD GDSARFVCVV
SGHPKPYIEW KHKGSLISFT DDISLQEESE VDNEDVFTIK QTLIFDKATA SSAGEIEVMV
TNIANKLSAT AKLSIEDYFD IFEDKPLSCE ESMAYEVELA NLTVQAGQNA DFVAKVTGKP
IPKIQWFKND EPLEESSRIR ITNSGREHRL QILNVNKDDV GVYRVRSYNG FEELSSCAEL
AVTETEISTQ RLSTTKFDGD VVFEMLCTKY LLHYMKVPIP NVKTAKPLQK RWILKKVYYG
TKADGEPLLS NWDASFSSDY FFRQELNKQK VMKEDVTLTK LVARFQIKLN EASLNVGWFR
NGDLLDDNHP DIHRYRLGHS FDGKASVLFK NLYLFFNEVD
//
