ID T1EXE2_HELRO Unreviewed; 634 AA.
AC T1EXE2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESN91797.1, ECO:0000313|EnsemblMetazoa:HelroP165877};
GN Name=20201242 {ECO:0000313|EnsemblMetazoa:HelroP165877};
GN ORFNames=HELRODRAFT_165877 {ECO:0000313|EMBL:ESN91797.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP165877, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN91797.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP165877}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. {ECO:0000256|RuleBase:RU000679}.
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DR EMBL; AMQM01002192; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097700; ESN91797.1; -; Genomic_DNA.
DR RefSeq; XP_009030598.1; XM_009032350.1.
DR AlphaFoldDB; T1EXE2; -.
DR EnsemblMetazoa; HelroT165877; HelroP165877; HelroG165877.
DR GeneID; 20201242; -.
DR KEGG; hro:HELRODRAFT_165877; -.
DR CTD; 20201242; -.
DR eggNOG; KOG4294; Eukaryota.
DR HOGENOM; CLU_020415_2_0_1; -.
DR InParanoid; T1EXE2; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IBA:GO_Central.
DR GO; GO:0035725; P:sodium ion transmembrane transport; IBA:GO_Central.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 1.
DR InterPro; IPR001873; ENaC.
DR PANTHER; PTHR11690:SF301; AMILORIDE-SENSITIVE NA+ CHANNEL-RELATED; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 2.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|RuleBase:RU000679};
KW Ion transport {ECO:0000256|RuleBase:RU000679};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU000679};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000679};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|RuleBase:RU000679}.
FT TRANSMEM 570..592
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 634 AA; 72493 MW; F713C2AB5EB5B93E CRC64;
MGDNLKSEII KYGENTSVRG LSKYFKSKDV FLKLLWLGLL LGSTSYMSYR LYLLFSDYLE
YPVSTEYGEK VVWFKLFLEN DSGYGLKNVY YLFTLFLIIK VLSICDIVFK LNSEIFVLNF
DFQIGQSISF PDITLCNLDV FAEGEPKEIS VKDYLENLEN FKKRFQAILN NKTAIQWNEQ
HIDMKINGSS SIKLREVDEA FEEMTSLAGY IINLNRSRPQ SVDCPHFVVD CNFFGTNWFE
TKDKCSVSSF ARVWNANYYT CYTLKTSKLN VNSSTNIRGL NVLLNVGPPN SIQVPYRSSL
TSSQGRGVQV SVHSPGTPPD LKRGFNVAPG TENIVEIIQT NRNRLKLPYN KLGCTEDVTL
FSSSSVKYTP DVCIDYCQQN LVKSMFKCFT HQLNVPEKKI EKTPLCGNLS AFMNANMSMT
DDDIFFNSIL RLSGSLLWSQ LDKVYTKLIK YDESTEICSD NCLLPCKETV YQTFITSAAW
PQPSVQFDIF KKYYINGGCM DNVKIKNRYI NYFNKLSNNT KKEMFSSNLT QMQESLLVLK
FMMKQNFPYF QSDNPAYTDD MMIGSVGGML SLWLGITVAS GVEVIELIYL LFKRCWEKKM
QNKNTTNVTE TTNGKGDHVI DEDFPSIATT STKL
//
