ID T1F018_HELRO Unreviewed; 419 AA.
AC T1F018;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 37.
DE RecName: Full=Mab-21-like HhH/H2TH-like domain-containing protein {ECO:0000259|Pfam:PF20266};
GN Name=20202168 {ECO:0000313|EnsemblMetazoa:HelroP167992};
GN ORFNames=HELRODRAFT_167992 {ECO:0000313|EMBL:ESO10133.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP167992, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO10133.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP167992}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}. Mitochondrion
CC outer membrane {ECO:0000256|ARBA:ARBA00004572}; Single-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004572}.
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DR EMBL; AMQM01002883; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB095905; ESO10133.1; -; Genomic_DNA.
DR RefSeq; XP_009011947.1; XM_009013699.1.
DR AlphaFoldDB; T1F018; -.
DR EnsemblMetazoa; HelroT167992; HelroP167992; HelroG167992.
DR GeneID; 20202168; -.
DR KEGG; hro:HELRODRAFT_167992; -.
DR CTD; 20202168; -.
DR HOGENOM; CLU_656010_0_0_1; -.
DR InParanoid; T1F018; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IBA:GO_Central.
DR GO; GO:0007005; P:mitochondrion organization; IEA:InterPro.
DR GO; GO:0090141; P:positive regulation of mitochondrial fission; IBA:GO_Central.
DR Gene3D; 1.10.1410.40; -; 1.
DR InterPro; IPR024810; Mab-21-like.
DR InterPro; IPR046906; Mab-21_HhH/H2TH-like.
DR InterPro; IPR045909; MID49/MID51.
DR PANTHER; PTHR16451:SF7; MAB-21 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR16451; MITOCHONDRIAL DYNAMICS PROTEINS 49/51 FAMILY MEMBER; 1.
DR Pfam; PF20266; Mab-21_C; 1.
DR SMART; SM01265; Mab-21; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion outer membrane {ECO:0000256|ARBA:ARBA00022787};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 327..402
FT /note="Mab-21-like HhH/H2TH-like"
FT /evidence="ECO:0000259|Pfam:PF20266"
SQ SEQUENCE 419 AA; 48863 MW; 7F277B476269E78A CRC64;
MSRNQSKKTD NDKKSSDSDL GATILAGAAV VGLSAVAAYG LYKLFDSIFE DVEKEKDAAE
KLDEESCERR QPKPVSTDLN LKINDWNNSF SVLPKTNKDE LLFNYEKSIF IEEKFLTPLK
RIVEQVQKRF RESIQHNCNV RGIKFEQFIK CGWGRDFFLI KSLDYFTFLV PLTIDYYLFE
KIQADYKSYK LSSRHDGLNQ LKYKNELLTP TSVAEYMLFS VKNKFEEMLK MDNIVISQVN
ITGGCIFLIC NSSASPAVKV KVKMIPAVKI NDNYLVPAEN DSSYIWKLFF IDQEDSFLAQ
FSPLSMSHKI IFSTFVNISL TLNDYFSVLH TEHLKHIMFH LIEDQPYEVD WDLETVFEHF
VDFLIELQKC LDRKVLLNVF DESINMFYDL QDMPRKKLQK FIEEIISNKS WNKLLKSGF
//
