ID T1F0Y4_HELRO Unreviewed; 1233 AA.
AC T1F0Y4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 57.
DE RecName: Full=PR domain zinc finger protein 10 {ECO:0008006|Google:ProtNLM};
GN Name=20202484 {ECO:0000313|EnsemblMetazoa:HelroP168778};
GN ORFNames=HELRODRAFT_168778 {ECO:0000313|EMBL:ESO08862.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP168778, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO08862.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP168778}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01003085; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096023; ESO08862.1; -; Genomic_DNA.
DR RefSeq; XP_009012884.1; XM_009014636.1.
DR AlphaFoldDB; T1F0Y4; -.
DR STRING; 6412.T1F0Y4; -.
DR EnsemblMetazoa; HelroT168778; HelroP168778; HelroG168778.
DR GeneID; 20202484; -.
DR KEGG; hro:HELRODRAFT_168778; -.
DR CTD; 20202484; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_267490_0_0_1; -.
DR InParanoid; T1F0Y4; -.
DR OMA; THILKSH; -.
DR OrthoDB; 5394783at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 3.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24403:SF48; PR DOMAIN ZINC FINGER PROTEIN 10; 1.
DR PANTHER; PTHR24403; ZINC FINGER PROTEIN; 1.
DR Pfam; PF21549; PRDM2_PR; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 65..200
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 553..576
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 581..608
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 609..637
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 694..726
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 739..767
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 812..840
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 258..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..801
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 828..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 965..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1130..1151
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1167..1201
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 259..287
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..317
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 326..343
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..513
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 771..801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 840..861
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1130..1144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1233 AA; 139470 MW; ED5603B3BD454F99 CRC64;
MVKNNDNVTI NIDKEPSNAC GNTNASEKWC VICEEFYGTS TCTKHTFQHV EDTPVLSKSF
ASLPSVLEIV EVEASSENEK VYGVLAKTTI EKHTKFGPLI CEYNLCKLGE LCKFGKGVNK
LGSDMMMGRR DNVSFTIEKP NGQVYQNDFS NLDACNWMAL VRASANQNDQ NMIAMNHFDY
IYYVTTRCIQ LGDELKVWFS TNHVKVGQFG SCTSDDVGGD LIKAKEKLPL EKCKRKVKST
WKVKMKCKKS SRSYFNDVTD DDDDNDDKNN DDDDGGGGND AEACDGDDDD FVPSKRTAKL
ASKKTLKRKR SKNSRGRPRK RPPSDWLTSI DQSKSSSKMK SKSNKTLPCE KCDLVFDDLN
IFNVHIIAHG FDNDVCNGVA TENAANAATL ATGKTDEALS LQCPVCRDVQ YDSHADMLSH
TRLHALVNNN NNNSNNNLNI NNNGNKVLLK PFECQNYGVG DINNNNNNNN NNNYDDNYGN
NDQFVICDDV IEFIRNRNNN KGISNNNNNN NSNNNDDDDD DDDDIVGNSK LGKPPPIKIE
LLHDNDVEAD GTYSCPQCHR VYQHYRQLAR HIRLQHWPKS YACDHCDRKF SRSDKLRLHS
LRHSDHREFV CEVCGGQFKR KDKWKEHMKR QHPGSGSGLT GSDLSGFKRS RFGRKVEALL
ERGTDDDAGN TNAATAATTT PATPATLAYN DYPFKCEQCK LGFKRRGILV NHALKKHPTQ
HLSNFPELSQ PIVKSRYDYF CLYCNKIFKS STKRKTHILK SHPGCELPAS LRNCNKNSSS
SSSRNVIGST AATSSHSSTF SAKSGQILVQ PSSCDICYRQ FSSRSKLLQH KRQQHPQQQK
RHPKQQQTNQ QQSHQAQQQQ FVASNQQLQQ TLLQDSTRTS TELQQQQQQV YAATSTIHNI
NNLETPTICL EDASASFSNG ALILVPKTTE ALNFNLSQSD LSAGNVIFLS ANGLSESCNN
DNDNINNNNN INSNNNNNNN NGDNNNNNMV GNNKDAIGQS QIIQNLQPIT SLHLTQEQLE
HLQQQLLLQT QQQQLLLLQP QQQQQLQPQQ FLLQHQPLLQ QQQPLLQQQQ LQQQQLLQQQ
QQIVLQDSVM THALDALSRS YVAKGKTNFN KKLTIQQLQQ RQQQQQLQQQ QQQKRPQLQK
HQQPQQHYKE QKRLQNVDDS HFGQNQQQQQ QQQLQQQQQL QQQLQQQLQQ QLQQQQQLQY
MMSTLSATSS ITTTPGTAAS SNTTFLTFAW SSS
//
