ID T1F1Y9_HELRO Unreviewed; 1107 AA.
AC T1F1Y9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN Name=20202839 {ECO:0000313|EnsemblMetazoa:HelroP169460};
GN ORFNames=HELRODRAFT_169460 {ECO:0000313|EMBL:ESO08586.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP169460, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO08586.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP169460}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; AMQM01003288; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01003289; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096080; ESO08586.1; -; Genomic_DNA.
DR RefSeq; XP_009013516.1; XM_009015268.1.
DR AlphaFoldDB; T1F1Y9; -.
DR STRING; 6412.T1F1Y9; -.
DR EnsemblMetazoa; HelroT169460; HelroP169460; HelroG169460.
DR GeneID; 20202839; -.
DR KEGG; hro:HELRODRAFT_169460; -.
DR CTD; 20202839; -.
DR eggNOG; KOG1217; Eukaryota.
DR HOGENOM; CLU_282332_0_0_1; -.
DR InParanoid; T1F1Y9; -.
DR OrthoDB; 19806at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 5.
DR Gene3D; 2.10.25.10; Laminin; 9.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR PANTHER; PTHR24034; EGF-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR24034:SF194; NIDOGEN (BASEMENT MEMBRANE PROTEIN); 1.
DR Pfam; PF07645; EGF_CA; 9.
DR SMART; SM00181; EGF; 7.
DR SMART; SM00179; EGF_CA; 9.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 4.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 4.
DR PROSITE; PS01187; EGF_CA; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 457..498
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 640..681
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 685..727
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 732..772
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 200..228
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 241..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..915
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 949..975
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 206..220
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..906
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1107 AA; 124527 MW; F308BED353ECFA25 CRC64;
MNIQHINVVC SAIVDLFSEI RTLDSIERND VGKQWFRHSG GTCSAHPLFD TSNDQHNTCL
VSIDICCLAE LRKQKCLLGR KKALSGEPCR AMHEDSNECC NCCSLGLKSR ETRNSCPKLP
RTKLFTCQCR ESYIRCCNYG LQNKTKVLER SKYDIADPCL TSQHNCTWKE RCLFKKSSKT
FICLPIASDA NKQLNMDGTN VVTSSQKGKH KKHPHHHKSS SNNNNLRAGA NDVTVAGELE
ISKSLDHSAT NKRARGNEGE KRWSRSSKHQ AACRAGFQFN EDTSTCQDIN ECLSHINPCK
ERSMCLNTEG SYECLSSMVH DSSSIDLRHV SLHNKGQHDS RYDIQVDNEE QFLKKKNKVL
QKHEHDDRYD SNGHYYNNGV VNDDHNSIAA SSSSLSPSAA ATTPNYINVH LYGKEHFNLN
NYENDKNDEV VVEKDGEKLN ACGSGFVWSE SSGRCQDVDE CETIRCPSLH MSCRNNPGSY
LCVCNEGFKF NPRSRSCEDT DECQTVTHNC EAQETCVNTV GSFQCTSAMQ QCAKGWLWDD
QLQQCTDINE CEARQHNCKS DEMCQNSLGS FVCVRYECDA GFEFNEESKG CDDVDECEAG
RHTCSARQTC VNLVGSYVCR NDSACPTGYF HSVILNICQD VNECSDSSLH NCTKPNMLCQ
NRDGGFTCTC LAGYTYHQYS QICVDVDECL EAVQRGIHIC PADSTCENKH GTFTCVCPPG
FFYDESTQTC IDFDECAIGL HGCDQACQNS WGSYYCTCRP GYVLNWDGRT CTAGHASPSL
QSYTDCPAGY TMNHLDGECY DTDECKEQRH TCPLETHMCV NTDGSFYCHP IVCPAGFHRL
MDGRMDGSRK YWMNVDRENS KDQEEHNFIE TPEQVVSNRN DADNFFYQND SPDVSSSSSS
SSSSRMKRVK RFLHSKSANK DDYSKNINSK NRKKLINFFY NISNNISSNN TKSNSASDSS
GVVCKKKKCG RSSRPSDVAC RSNSTLSIQW NQMSLASIPQ LSTATTIINI QPENVDRRLS
YEFLLVNTRL LSGKDNGNAN DLFQIHKVSD WFGDKGEIYL LRSIRGAATY ELEISLKTYL
KMYSNMKSGY LSEHLMHIII YVSTLTL
//
