ID T1F340_HELRO Unreviewed; 477 AA.
AC T1F340;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Immunoglobulin subtype domain-containing protein {ECO:0000259|SMART:SM00409};
GN Name=20203239 {ECO:0000313|EnsemblMetazoa:HelroP170481};
GN ORFNames=HELRODRAFT_170481 {ECO:0000313|EMBL:ESO07171.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP170481, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO07171.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP170481}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01003572; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096222; ESO07171.1; -; Genomic_DNA.
DR RefSeq; XP_009014549.1; XM_009016301.1.
DR AlphaFoldDB; T1F340; -.
DR EnsemblMetazoa; HelroT170481; HelroP170481; HelroG170481.
DR GeneID; 20203239; -.
DR KEGG; hro:HELRODRAFT_170481; -.
DR CTD; 20203239; -.
DR HOGENOM; CLU_572761_0_0_1; -.
DR InParanoid; T1F340; -.
DR OrthoDB; 5343005at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
DR PANTHER; PTHR12080:SF48; IG DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12080; SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE; 1.
DR Pfam; PF07699; Ephrin_rec_like; 1.
DR SMART; SM01411; Ephrin_rec_like; 1.
DR SMART; SM00409; IG; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..477
FT /note="Immunoglobulin subtype domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010980215"
FT TRANSMEM 363..386
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 53..149
FT /note="Immunoglobulin subtype"
FT /evidence="ECO:0000259|SMART:SM00409"
FT REGION 437..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 477 AA; 54420 MW; A229C4CAC2D1E446 CRC64;
MINVRHTLLG LLSIIAVCLV SCQNDNVSGK NIPEKEKDKV ELAAFNFSVL EAKRTVCARQ
EENVWLHCVP EWISREVENN LQSQIIEGFW KSETGHKLPG PLEPRRFQID KRYRLLILDA
KSIDTGTYTC TIILKSKKLK TSTVRLTVYE LPMFGMEFPL VFRLNGSCTK HKRLVEASLN
EMQGLLCGFR ERLDAAQPVC QFNVHDVACR RVTLHTMIEN NEPEVFLEIT VRKLPHPKFK
SPRCSEECMK NYFSLHINSN LEQMIKQLLT MRQYFHVCPR GFRLRKNCRN RGSICLPCSP
GTFSENGLIN YCNKCPVDTY QSFYGSKSCM PCDSSQGTGT KKGSIQAEDC RTHQSYPKYS
VTLTYSLVLL TIASSLALFG ITVAMLEGWC PMNMGKRLIN EMERRKSRKQ AQFIAKLREK
AHKRLIINKS KSDESKSKEV LQKAEEISRG SFKDSKTFTT RAPTPAKNIN TSTTLAT
//
