ID T1F3Q2_HELRO Unreviewed; 1841 AA.
AC T1F3Q2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=Cadherin domain-containing protein {ECO:0000259|PROSITE:PS50268};
GN Name=20203451 {ECO:0000313|EnsemblMetazoa:HelroP171023};
GN ORFNames=HELRODRAFT_171023 {ECO:0000313|EMBL:ESO06987.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP171023, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO06987.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP171023}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01003750; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01003751; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096275; ESO06987.1; -; Genomic_DNA.
DR RefSeq; XP_009015083.1; XM_009016835.1.
DR EnsemblMetazoa; HelroT171023; HelroP171023; HelroG171023.
DR GeneID; 20203451; -.
DR KEGG; hro:HELRODRAFT_171023; -.
DR CTD; 20203451; -.
DR eggNOG; ENOG502QVM0; Eukaryota.
DR HOGENOM; CLU_237129_0_0_1; -.
DR InParanoid; T1F3Q2; -.
DR OrthoDB; 2957234at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 6.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013164; Cadherin_N.
DR PANTHER; PTHR24028:SF146; CADHERIN FAMILY; 1.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR Pfam; PF00028; Cadherin; 4.
DR Pfam; PF08266; Cadherin_2; 1.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 6.
DR SUPFAM; SSF49313; Cadherin-like; 6.
DR PROSITE; PS00232; CADHERIN_1; 4.
DR PROSITE; PS50268; CADHERIN_2; 6.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043}; Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..30
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1110..1136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 47..122
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 126..233
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 234..341
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 348..476
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 477..573
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 574..682
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 851..877
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1039..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1209..1335
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1351..1378
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1623..1646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1711..1733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1799..1821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1209..1256
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1299..1315
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1353..1378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1630..1646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1841 AA; 206895 MW; 958ADE59B7E1E00F CRC64;
MDSRDVPGQQ LRLIRFIVFG FLSTFVGDVM EGSGLMTNQS SDVLEVVQFK FAGSVEYFYI
DSKTGVITTS SQIDRDSPSL CRQRVDCQVH FSVIVVHPTR FMIMMIKIII TILDINDNEP
RFLTKNSGHF NLDINEAVAT NSFYPLPSAT DYDSPVNGIT RYVMDPPLKN FEIQLFWKLD
GGKEVRLVVT GGLDREEKDF YFFELMAFDS GTKPAVINIT ITVLDSNDNK PTFSDATYHT
NVAESLPIGT TIMHVSASDP DLGASGHVTY QLSGHSSEKY GHIFAVDGLT GSVHLKQALD
REASSIYQLV ITAKDNGPGS MTSEATLTVK VDDVNDNHPI IVVHSLGRHN TTTATVTENA
PPETFVAHII TSDPDEADNG KVSCQLMTKK SENAENLGLL HQSFYTQQQD PFKLLQKSHQ
GEYQITTTTT TKLDREQQHV FYLLLRCKDA AVKNSLSTEL VIQVNILDEN DNSPIFGQPS
YNQTIKENNI VGMPLLSVFA HDLDENANGH VTYSIEGNAS EVFNVDENGL VTARVSLDRE
VMDFYQFPLL ALDGGTTTVY ITVEDENDEK PTFEKDRYWM RVLENQPSGT FVGEVVATDR
DGPPNNLFIY VLEEYDDGVA ADLFAIQPQT GMITTRQVLD REVLQGKYRL VVVAKDIKSQ
SMSGTSDLMI EILDLNDNQP EILFPSAGND THHVSSQLPV GGHVVQIVAR DLDASVEYNR
LLFSMEEVGV FEDVDVARIV VYEIMSRSQQ HQQQQQQHQH QQVLPKITTT NTNTTSDSVK
SVTVIKTSPL TTTSTKILLA KTPTTTKSAT KSFVTITSST FLASNISDYA NFLPPRHSHF
SPIASTPPPN HNNHHSIDNN SNINNNSNIN NNSINNNNSS NIYSQQFLTT KRTTTAANNT
NAIFEKLQTS ILQQNNANNN INNDNINNDL SNNNDVTANK SNLFRIQSNN GLIMSLDRLD
HKSYINRVIC IVVKVTNPTI ANGNFVNNNN NNNIGSTNNN NNIRNNIKNS TFSMNATSDK
YDTGVENISK DLNQINNTHA PSININNNNN NKNNTQQLTQ QQQQQQHTSL AILFLIINST
IPPPPLRSQT ISAQKNSSKN YGVIKEIGGI LLYLILAVVG GCVFVVSCVV VAVVVVRKRE
LRKRRIGGLQ KFNGDLIGLH NNSGCPNVEG NSGNRSDGAA ANYNDKNKIN SSAGCKESSG
KVCEKKMGFV GNSSNNNNNN KEKHKINNSN DNNNNNYYIK DNDSNIGNSV PNISNKTDNR
SDHENTKLSL SAGPEIQKSR DLSGTYGRGK GENRESDNCG CDGEEDDEDE NNGDVLNRDE
DALCDVADDG DDDDGMVLMT PRDGDKYALS WSKPGRTISS NRKFHFNDNN NNNNSNNNFI
QFDLISNPPP SSQSASSKKL ILPPPPPARG NFWKYPEYQQ NTQHNTQLSS MSILPIKHSD
DTQQQQQFPS PPITTTTATK TTNNIDYFQQ QHDFATNLNK QQQRTVNADN NNNLHIQPCY
YTTSQTLKPA HSINFNKFCP MTFANSTATT STTLRPFSNK SQQHVQHKCY CETLVNNNEN
ASSQEKLLFN KSSQQLKYIS LQQFQQQQHQ QQHLQQKSLQ QTLGNPKKRL QEHQHQYNLY
HHQHHYHLQR PRSAQQQPIQ QQQQQQISQQ PQIQQQNLLL QQQQFYIQQH QLQQPCIKTT
NQQKFQQSQH HQQQQNYQIQ HNLLQHQQYF NQQQHRQQQQ HYSTKPATTA TTRPSTLRFD
ESMNIIHNIE PVECCENYDY DDSNNNNDNK TQYNYNNLDI LSSSHFSSSK RVVHKGANNI
SNSSTISNDP KDDDTHNTHI HNETHTKTHT HYMLLECLDI K
//
