ID T1F4R4_HELRO Unreviewed; 608 AA.
AC T1F4R4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Endonuclease/exonuclease/phosphatase domain-containing protein {ECO:0000259|Pfam:PF14529};
GN Name=20203813 {ECO:0000313|EnsemblMetazoa:HelroP171831};
GN ORFNames=HELRODRAFT_171831 {ECO:0000313|EMBL:ESO05429.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP171831, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO05429.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP171831}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01003938; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01003939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096365; ESO05429.1; -; Genomic_DNA.
DR RefSeq; XP_009016744.1; XM_009018496.1.
DR AlphaFoldDB; T1F4R4; -.
DR STRING; 6412.T1F4R4; -.
DR EnsemblMetazoa; HelroT171831; HelroP171831; HelroG171831.
DR GeneID; 20203813; -.
DR KEGG; hro:HELRODRAFT_171831; -.
DR CTD; 20203813; -.
DR eggNOG; ENOG502SAHD; Eukaryota.
DR HOGENOM; CLU_031658_0_0_1; -.
DR InParanoid; T1F4R4; -.
DR OMA; YINIPQI; -.
DR OrthoDB; 3807045at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR PANTHER; PTHR33776; ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR33776:SF3; PHD-TYPE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF14529; Exo_endo_phos_2; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 206..315
FT /note="Endonuclease/exonuclease/phosphatase"
FT /evidence="ECO:0000259|Pfam:PF14529"
SQ SEQUENCE 608 AA; 69290 MW; A376C2CB189045CF CRC64;
MNMNPDSGRA MNWCDAVSYD VCVASDVVDM DDADEDETMP IVLDVDGSCV LNNFDDVDAI
VNCEYYMPNN ISHYFVFCEL IDFLNVSANN NSNLFLLHIN VRSLTAHADD LALLINGFQL
YINIPQIVAL SETWLNDDTN YGPILSYFPC HSLVAKNRVG KRGGGTGFLI DKNLAYENLN
CNFSLSSDLF EWVGIKFASN NKKNIIICIY RPPNYKLDNF LSKMQEFLYE LLRDDVSSDV
FILGDFNIDL AVKNQASLSF LNLMAQFNLH PIINQPTRIT SSHSSTIDNV FTNYGIGGCP
KGILYSDVSD HLPIFLCIPL NAKAVGGKNP YIKTRLINSE NLKKANCLLQ NIQWNMSDYW
SDFESDFESN FKKFLKTYLN CINLALPLVN KKNRFRRPWM NIDLYNLSLY KNVLYKRHLH
NPSPANKNAY NKVKNKFINV KRFTEKKYFE NKLKNQPGTK HRWRIINEIL GSKKSCNKLF
SNDASETAKL STVTGLNKFF VEIGKNINKI LGDGQLISNV GPYVVSNNPI FIPRDTTPDE
IVSVITSATR QHGMLMPKKV RTSTYDRSWV AKGVRLWNAL AMHNQLQLTI EHFKHYAKSE
VMSMSVDV
//
