ID T1F5D6_HELRO Unreviewed; 499 AA.
AC T1F5D6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Rho-GAP domain-containing protein {ECO:0000259|PROSITE:PS50238};
GN Name=20204035 {ECO:0000313|EnsemblMetazoa:HelroP172479};
GN ORFNames=HELRODRAFT_172479 {ECO:0000313|EMBL:ESO04804.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP172479, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO04804.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP172479}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01004234; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096457; ESO04804.1; -; Genomic_DNA.
DR RefSeq; XP_009017383.1; XM_009019135.1.
DR AlphaFoldDB; T1F5D6; -.
DR STRING; 6412.T1F5D6; -.
DR EnsemblMetazoa; HelroT172479; HelroP172479; HelroG172479.
DR GeneID; 20204035; -.
DR KEGG; hro:HELRODRAFT_172479; -.
DR CTD; 20204035; -.
DR eggNOG; KOG2710; Eukaryota.
DR HOGENOM; CLU_546642_0_0_1; -.
DR InParanoid; T1F5D6; -.
DR OrthoDB; 2883046at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR042869; ARHGAP11A/B.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15670; RHO GTPASE ACTIVATING PROTEIN 11A; 1.
DR PANTHER; PTHR15670:SF4; RHO GTPASE-ACTIVATING PROTEIN 11A; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 1..164
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 264..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 264..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 499 AA; 56200 MW; 5067F7875D92F53E CRC64;
MLKKHLDSEG LFRKSGSFTR QKEIKETLSM NFDPSQLEVL SAYDLSDLIK LFLRELPEPL
FTSRLQGFFL VCSSIGQCEL IQTQLMLCLL LPRPHLHLLR YLCHQLYIVS EHSPMNHMNA
TNISICLAPN MFKLSHSLHN ADLKLAQKQA DVLKILVENH NLIGMLTDDI VAKVTEMSLK
QQRINSSFLE STNFEGCIHF GDENISKEID LSCRDVDVGC HVDDVAGCRG GDAEAGGRTS
RMKKRSTSLQ GLVKDISANF TRWRSSSNKR QQSLTSTPQQ LSTNNLREKS TLQSRSQHPT
ALLQQHEKHQ HDLAITEGHN LFKRRIKRAI LTNVMPDVVP INNGNNNNKL HNNIDNINMD
NITAKNHKVK LLNDINSNFH NRINICDNVQ RGHYNFNVMN SNNDNDNDNI LNENTNASGC
NSISALHRDF MKSTQFYLSR PVTCPPTTFT STFLYNFKNE FATTSSTKIS IARGVTAGTT
LTTTTSCATY LASTQDCIG
//
