ID T1F7A1_HELRO Unreviewed; 470 AA.
AC T1F7A1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Endonuclease/exonuclease/phosphatase domain-containing protein {ECO:0000259|Pfam:PF14529};
GN Name=20204700 {ECO:0000313|EnsemblMetazoa:HelroP173822};
GN ORFNames=HELRODRAFT_173822 {ECO:0000313|EMBL:ESO02987.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP173822, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO02987.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP173822}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01004733; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096676; ESO02987.1; -; Genomic_DNA.
DR RefSeq; XP_009018680.1; XM_009020432.1.
DR AlphaFoldDB; T1F7A1; -.
DR EnsemblMetazoa; HelroT173822; HelroP173822; HelroG173822.
DR GeneID; 20204700; -.
DR KEGG; hro:HELRODRAFT_173822; -.
DR CTD; 20204700; -.
DR eggNOG; KOG1075; Eukaryota.
DR HOGENOM; CLU_046344_0_0_1; -.
DR InParanoid; T1F7A1; -.
DR OrthoDB; 2970096at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0031012; C:extracellular matrix; IBA:GO_Central.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0061343; P:cell adhesion involved in heart morphogenesis; IBA:GO_Central.
DR GO; GO:0007508; P:larval heart development; IBA:GO_Central.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR PANTHER; PTHR33395:SF21; REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR33395; TRANSCRIPTASE, PUTATIVE-RELATED-RELATED; 1.
DR Pfam; PF14529; Exo_endo_phos_2; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 313..429
FT /note="Endonuclease/exonuclease/phosphatase"
FT /evidence="ECO:0000259|Pfam:PF14529"
SQ SEQUENCE 470 AA; 54232 MW; 3CA8BE187C9D799F CRC64;
MERKKKPKDT VSELKCTDND NLGLKLCEEC MKCNREKLQI LVETEKAASL DLGPSLEVYK
SEMRDITHSM MSKMEILEKA IYAQNEEWSD LRKRMENISI ISLKQLEDNE KITKKTVEKS
EQVLMKYSEA VKGKVDTLAT DVKKMQKSIL DTTTKIDINN DREKRKNNII LYNLDEKENN
PRVCVGKLLK EIADIDSEVV DISRLGRKSE EAKPRPVLVQ LASLTTKNLL FANCFKLRNS
TCFSKVIINH DLSKEDRISN KKILEEKKSF AEVNKRGLVL YYKNSIVVSE VAMKSDFKEH
ISVKLVMSKS ILNIVFIYRS PKSDEKNNKN LLSLLIEGLS LNGDFLMLGD FNFPEIDWET
FSCRGSDEKI ENEFLSILKD KFLIQHINFP TRFRDGQAAN ILDLVISAKE LVRNIMHHPP
LGNSDHSIVE FKVIGFRCPP EKYKKKYCYD SGNYESLCII KKHLRVVRAN
//
