ID T1F7F2_HELRO Unreviewed; 609 AA.
AC T1F7F2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE RecName: Full=Nucleotide-diphospho-sugar transferase domain-containing protein {ECO:0000259|Pfam:PF03407};
GN Name=20204751 {ECO:0000313|EnsemblMetazoa:HelroP173963};
GN ORFNames=HELRODRAFT_173963 {ECO:0000313|EMBL:ESO03083.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP173963, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO03083.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP173963}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 77 family.
CC {ECO:0000256|ARBA:ARBA00007033}.
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DR EMBL; AMQM01004767; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096676; ESO03083.1; -; Genomic_DNA.
DR RefSeq; XP_009018776.1; XM_009020528.1.
DR AlphaFoldDB; T1F7F2; -.
DR STRING; 6412.T1F7F2; -.
DR EnsemblMetazoa; HelroT173963; HelroP173963; HelroG173963.
DR GeneID; 20204751; -.
DR KEGG; hro:HELRODRAFT_173963; -.
DR CTD; 20204751; -.
DR eggNOG; ENOG502QT5X; Eukaryota.
DR HOGENOM; CLU_448554_0_0_1; -.
DR InParanoid; T1F7F2; -.
DR OMA; AFECTEY; -.
DR OrthoDB; 2951179at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IBA:GO_Central.
DR InterPro; IPR005069; Nucl-diP-sugar_transferase.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR47032; UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED; 1.
DR PANTHER; PTHR47032:SF1; UDP-D-XYLOSE:L-FUCOSE ALPHA-1,3-D-XYLOSYLTRANSFERASE-RELATED; 1.
DR Pfam; PF03407; Nucleotid_trans; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 63..82
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 192..395
FT /note="Nucleotide-diphospho-sugar transferase"
FT /evidence="ECO:0000259|Pfam:PF03407"
SQ SEQUENCE 609 AA; 70817 MW; D0E86414CC1D4A71 CRC64;
MEKENPANEV KFLNGMTLEE CLPPNLNIFF LFLVPICLIR HLLTPNFTCQ STAGDEFLSE
KTYILMLLIL VVFCFLSTNY LLNKRHKQPF IVLMINTEVK EVNIDDPQTA EEIEQMRQKL
NFYQSTRAPK KLLKLINSKE NARQIKSKPS ATLVDGLKKH SSPVGDIILS VTDADYVSFA
LNFYYLSIVR NKIQNFLFVC LDKQSYETLT KLDIPASMHS LSFILKNDFM SSDFGKLGYI
YKTNLKTAVM VQALSLGYSV LMCDVDVIMF KNPFTFFTCS NCSIHIQKDR QMYNSGFVYA
KPTKTSKYIY EKSWNLFVKY QKSHDQSYLN MAIHQLAEKE NVFDALKVLS RREFPCGLYY
FEEVHRPFKN EPPCVECAIM HNNYLGSVAA KLYRLKENHF WIIDSKGYYS DPNAKYITYD
NPVHFEKIRT MDIEISSLKS ALAIASVLNR ILILPPFHCC NCHPDNKCSH PKYRCSLLSM
LRISKFDQYF KLKYREHSFL DHPLVPDAVK SSVSPELLIN HSTYRKKFGI SSEHFLNPKN
AEKGASLEEV ETWLTNYSNY SVIKLHSLYG ASSFQHHTDN RYTRLENIFA DAFECTEYEQ
WEKNFLAFK
//
