ID T1F897_HELRO Unreviewed; 980 AA.
AC T1F897;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Citrate transporter-like domain-containing protein {ECO:0000259|Pfam:PF03600};
GN Name=20205046 {ECO:0000313|EnsemblMetazoa:HelroP174576};
GN ORFNames=HELRODRAFT_174576 {ECO:0000313|EMBL:ESO01618.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP174576, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO01618.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP174576}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AMQM01004964; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096743; ESO01618.1; -; Genomic_DNA.
DR RefSeq; XP_009020272.1; XM_009022024.1.
DR AlphaFoldDB; T1F897; -.
DR EnsemblMetazoa; HelroT174576; HelroP174576; HelroG174576.
DR GeneID; 20205046; -.
DR KEGG; hro:HELRODRAFT_174576; -.
DR CTD; 20205046; -.
DR eggNOG; KOG1281; Eukaryota.
DR HOGENOM; CLU_303713_0_0_1; -.
DR InParanoid; T1F897; -.
DR OrthoDB; 3264498at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:UniProt.
DR InterPro; IPR004680; Cit_transptr-like_dom.
DR PANTHER; PTHR10283:SF82; PROTEIN I'M NOT DEAD YET-RELATED; 1.
DR PANTHER; PTHR10283; SOLUTE CARRIER FAMILY 13 MEMBER; 1.
DR Pfam; PF03600; CitMHS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 160..181
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 201..220
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..282
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 196..311
FT /note="Citrate transporter-like"
FT /evidence="ECO:0000259|Pfam:PF03600"
FT REGION 1..51
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 63..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 108..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 351..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..743
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..980
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 358..392
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..718
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..954
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 980 AA; 111366 MW; 3DC2A8750EAA36A0 CRC64;
MGLWNEKQTS ANKTTSPLTD QPNAQQQPQQ PQQPQQLQQP QQQLSRRSTA SHDVFPSFIS
MATQTSSRDQ EVSNRQPNSQ SATVNPPSFL AAASHILDNE KLQKQNKQLR TRLNPTTTQT
TPGTASTTVS KESNHSNTSQ PRQSLIPMGY FRSVLLEILL YRKMILVFFF PLIYLPIPIF
YPDIVSFGYC MFRSYWTTEA LPLAVAGLLP CILMPLLSVV KIEELAMEYI KDSSLMFYGG
LIIAVAIEKC NLHKRLAMAV LLIVGTSARW VAFGFMATSW FLSMWMNNTA TATMMVPLVS
ALIGQLKNSR KKKLQNIGTE LLKIAVQKPF PDGRPRHYRI SNVIKSVSLP PSDIRQKGKR
ASSLNFSQTS EDNASTRKVK SENIVNKGNN MNYNNNSINN NINNNDNINN NTNINSNKNN
INNTNINNNN ININDNINNN NSINKNSNYN SVNRSCIETS TVDHNHSANA NCDDINTMMM
TNSINEFNYK DSVIKSSYSS NDDMKSCSCP YYDRDINYSL FGNCFSFNFQ KIFSDIKNVI
TKNNSSNNNN NININNSRNN NSISNNNNNI KYTRYPVQFL NNNTSKKIPE NGITSTETNT
TSFTNLDCQQ KLRDKNSIEG NNYSNIGAES VSTRSNVSLS SASSSIGSCY KHCDHIETRC
TQRSSQCNSV NDVLSYVRGD GCKNNCTDNN NNDVMYNNIN NNNNNSSNSN NNNNDDKGRN
SKASNRSEKL NKTSQKLPKK PTFATKIKNL FTKKDDEKFR KTLQERQMKL EQQLHMQQHI
LQQRQRSQTP SVTNLQDIQT QPALFQVSKF DEERKRSRRG DQVYFDLTQS DLMNAVKNDL
VIKQSSKKPP KFSLFDSNYL RKSSVTTDGS LKKLFKISFR SEPGRTVGQR PRYQHEITEN
MDKDGNFVIP PQNDVENMIN DNDGGRRKIA WLQRQNFQKE IKERTKKDEK DDNKNDDDEY
TDDDNAGKMK ANTRRTSADM
//
