ID T1F8A9_HELRO Unreviewed; 136 AA.
AC T1F8A9;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Nuclear nucleic acid-binding protein C1D {ECO:0000256|ARBA:ARBA00015212, ECO:0000256|RuleBase:RU368003};
GN Name=20205058 {ECO:0000313|EnsemblMetazoa:HelroP174618};
GN ORFNames=HELRODRAFT_174618 {ECO:0000313|EMBL:ESO01655.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP174618, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO01655.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP174618}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Plays a role in the recruitment of the exosome to pre-rRNA to
CC mediate the 3'-5' end processing of the 5.8S rRNA.
CC {ECO:0000256|RuleBase:RU368003}.
CC -!- SUBUNIT: Monomer and homodimer. {ECO:0000256|RuleBase:RU368003}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU368003}.
CC Nucleus, nucleolus {ECO:0000256|RuleBase:RU368003}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU368003}.
CC -!- SIMILARITY: Belongs to the C1D family. {ECO:0000256|ARBA:ARBA00009154,
CC ECO:0000256|RuleBase:RU368003}.
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DR EMBL; AMQM01004981; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096743; ESO01655.1; -; Genomic_DNA.
DR RefSeq; XP_009020309.1; XM_009022061.1.
DR AlphaFoldDB; T1F8A9; -.
DR STRING; 6412.T1F8A9; -.
DR EnsemblMetazoa; HelroT174618; HelroP174618; HelroG174618.
DR GeneID; 20205058; -.
DR KEGG; hro:HELRODRAFT_174618; -.
DR CTD; 20205058; -.
DR eggNOG; KOG4835; Eukaryota.
DR HOGENOM; CLU_064339_4_1_1; -.
DR InParanoid; T1F8A9; -.
DR OMA; KRCQNIC; -.
DR OrthoDB; 73913at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0000178; C:exosome (RNase complex); IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0000460; P:maturation of 5.8S rRNA; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR InterPro; IPR011082; Exosome-assoc_fac/DNA_repair.
DR InterPro; IPR007146; Sas10/Utp3/C1D.
DR PANTHER; PTHR15341:SF3; NUCLEAR NUCLEIC ACID-BINDING PROTEIN C1D; 1.
DR PANTHER; PTHR15341; SUN-COR STEROID HORMONE RECEPTOR CO-REPRESSOR; 1.
DR Pfam; PF04000; Sas10_Utp3; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU368003};
KW DNA-binding {ECO:0000256|RuleBase:RU368003};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU368003};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU368003};
KW rRNA processing {ECO:0000256|ARBA:ARBA00022552,
KW ECO:0000256|RuleBase:RU368003}.
SQ SEQUENCE 136 AA; 15705 MW; 04240E60FAF890A2 CRC64;
MDFSELPSNI ITSLNDLNAN LDIVESKYNQ FYDRSLSEEH EKMTPLEKAK SEIVAAHTIN
SLFFIYLQLN GQDVSKHPIN YELNRVSKSI ARVKEIEDKR LAPKLDISAS KRFVKSALWD
KDQQAKKPKL DVEKRP
//
