ID T1F9F6_HELRO Unreviewed; 351 AA.
AC T1F9F6;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=RNase H type-1 domain-containing protein {ECO:0000259|PROSITE:PS50879};
GN Name=20205455 {ECO:0000313|EnsemblMetazoa:HelroP175615};
GN ORFNames=HELRODRAFT_175615 {ECO:0000313|EMBL:ESO00637.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP175615, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO00637.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP175615}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the RNase H family.
CC {ECO:0000256|ARBA:ARBA00005300}.
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DR EMBL; AMQM01005376; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096900; ESO00637.1; -; Genomic_DNA.
DR RefSeq; XP_009021274.1; XM_009023026.1.
DR AlphaFoldDB; T1F9F6; -.
DR EnsemblMetazoa; HelroT175615; HelroP175615; HelroG175615.
DR GeneID; 20205455; -.
DR KEGG; hro:HELRODRAFT_175615; -.
DR CTD; 20205455; -.
DR eggNOG; ENOG502S3RQ; Eukaryota.
DR HOGENOM; CLU_790574_0_0_1; -.
DR InParanoid; T1F9F6; -.
DR OrthoDB; 3150104at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IBA:GO_Central.
DR GO; GO:0043137; P:DNA replication, removal of RNA primer; IBA:GO_Central.
DR CDD; cd09276; Rnase_HI_RT_non_LTR; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR PANTHER; PTHR10642; RIBONUCLEASE H1; 1.
DR PANTHER; PTHR10642:SF28; RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00075; RNase_H; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50879; RNASE_H_1; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 1..80
FT /note="RNase H type-1"
FT /evidence="ECO:0000259|PROSITE:PS50879"
FT REGION 218..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 351 AA; 40829 MW; 3A236A5E7727C087 CRC64;
MALSSIYNST GKNYQIFTDS LSTLLALKQY YPRHQLILQI QNKIHDIISN KNHISLIWIP
SHIGIEGNER VDQLAAQAHL DPPSNIPIPH YDIRVMTNDL ICSKWQKEWD KITNFLKIVM
PELNSSQNTK INELSRNNLN IINRLKLGHS KITHSWILNK TNPPICENCD TKLTIQHILI
ECQNYNEIRK KHQIPNDIRS IFKDEKLQNL STKENRINKD QGRKDSLSEL KRRKTAEEEE
EEFQNITDRR YRSNVESIRT EPVQKPSSSE SKIIKCPLRT SELAIEGRVI LRHEIIFYPN
LRGSENRAHI SFWIGSQQNT TAEPSPTATT TARNAQQPDK HIYIYILSKK I
//
