ID T1F9H0_HELRO Unreviewed; 710 AA.
AC T1F9H0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE RecName: Full=GDNF/GAS1 domain-containing protein {ECO:0000259|SMART:SM00907};
GN Name=20205469 {ECO:0000313|EnsemblMetazoa:HelroP175648};
GN ORFNames=HELRODRAFT_175648 {ECO:0000313|EMBL:ESO00667.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP175648, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO00667.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP175648}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the GDNFR family.
CC {ECO:0000256|ARBA:ARBA00005961}.
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DR EMBL; AMQM01005388; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096900; ESO00667.1; -; Genomic_DNA.
DR RefSeq; XP_009021304.1; XM_009023056.1.
DR AlphaFoldDB; T1F9H0; -.
DR STRING; 6412.T1F9H0; -.
DR EnsemblMetazoa; HelroT175648; HelroP175648; HelroG175648.
DR GeneID; 20205469; -.
DR KEGG; hro:HELRODRAFT_175648; -.
DR CTD; 20205469; -.
DR HOGENOM; CLU_016517_0_0_1; -.
DR InParanoid; T1F9H0; -.
DR OrthoDB; 3899332at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0043235; C:receptor complex; IBA:GO_Central.
DR GO; GO:0038023; F:signaling receptor activity; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR InterPro; IPR016017; GDNF/GAS1.
DR InterPro; IPR037193; GDNF_alpha.
DR InterPro; IPR003438; GDNF_rcpt.
DR PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR PANTHER; PTHR10269:SF12; GLIAL CELL LINE-DERIVED NEUROTROPHIC FAMILY RECEPTOR-LIKE, ISOFORM E; 1.
DR Pfam; PF02351; GDNF; 2.
DR SMART; SM00907; GDNF; 2.
DR SUPFAM; SSF110035; GDNF receptor-like; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 301..380
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 390..470
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT REGION 102..157
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 475..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 685..710
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..118
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 119..148
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 710 AA; 79538 MW; 02DF782609BCD91F CRC64;
MAVDDDVDAT ITTIDKKRAN LKKLLKALLK RLRMMAECRA LLTSLQTHPL FLNCMCFASS
SLQSDKECLD FQNRIFLHSC LGTSPNVSWI SKPEKKDAIS NVITDDDDDD DDDDENDVIN
NSNNNNDKNL LNNNKNNTNN NNKNNKNGDD NDNNGDDTDN DIDEKSCLWR RRWCSRESRC
LESLATFRAE CRENKNTKRC LPNNWSACHL SLISLRKHSR DLLSCQCGHF KNQQLNKKCH
KFQQNLLSNA CWDSAPYFVY TSKLPELTFS EQKTLALSSE TSNGCSSLPQ SDRRMSPISC
CLYVYRRCNL DQQCSSYLES MMHACYWESN GDHCNRKSCL TQIRNFFMKV KPDLALSLDS
RNEVIQSKCL KLKEVIIPTC SRVELPPPLC THLVDRCIDD DVCRQSWYDF NHHCPVETPK
YYKTSSFARC QENQKCTASI VYLMGTLLST NCTCFAKSNK LKASNLSNVL SNITVGSSSS
GSSSGSSSSG DGGDSSSSSS SSTAAEYKRC QSYRKLLHYK NYCLGLVDRP IVGKIIDDDD
DDVTDKNNNE DDDNADCNNY EISKVYAQQN DGSRFSLSDR GQCGCHRGQV ICVKPPYRVD
LPEGLFLHIG YSSVELSHLS KYIGVGIDSI TDLFNRILLY INGPLSQSSV SNVIVIILAS
AARSTYASFS HGTVAASFTT CRLRTSSSTP RSNPCTTTPT TTSDTNSIVY
//
