ID T1F9I2_HELRO Unreviewed; 1443 AA.
AC T1F9I2;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN Name=20205481 {ECO:0000313|EnsemblMetazoa:HelroP175671};
GN ORFNames=HELRODRAFT_175671 {ECO:0000313|EMBL:ESO00688.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP175671, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESO00688.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP175671}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01005394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB096900; ESO00688.1; -; Genomic_DNA.
DR RefSeq; XP_009021325.1; XM_009023077.1.
DR STRING; 6412.T1F9I2; -.
DR EnsemblMetazoa; HelroT175671; HelroP175671; HelroG175671.
DR GeneID; 20205481; -.
DR KEGG; hro:HELRODRAFT_175671; -.
DR CTD; 20205481; -.
DR eggNOG; KOG2353; Eukaryota.
DR HOGENOM; CLU_251744_0_0_1; -.
DR InParanoid; T1F9I2; -.
DR OrthoDB; 2914552at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005891; C:voltage-gated calcium channel complex; IBA:GO_Central.
DR GO; GO:0005245; F:voltage-gated calcium channel activity; IBA:GO_Central.
DR CDD; cd18773; PDC1_HK_sensor; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR018143; Folate_rcpt-like.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR PANTHER; PTHR10166:SF43; VWA_N DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF03024; Folate_rec; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 229..250
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 270..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1417..1441
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 491..730
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 1037..1060
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1037..1052
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1443 AA; 164431 MW; B36A8C3021134B5A CRC64;
MFWSNQAVFV TISSCFLAFI NIVVRSQFTD RYSLDDDKYA RLSSLDKVPA PVYNISGGVR
DQLLPVVKNI NLMMSSTKKS NSLQFCSFFN NRAPQEQLAL KNCTWYSKNS CCLQHEIDVS
FSRVKSLIGA SEDCQKYTNY LMCYVCSPDQ NLFYKKERLT VCEPFCDLLY EACKFAYLKG
YQIADLYSTG KEFCLSRRFL VEYRHDCFNM HDVNFEAMKF SSSSSSSPIN FIHICVLIFV
STILSTGSFI GKDYFMSVGG SKFKIHQTTG RGVCILVIIS IFMLSAQHTH AFKVSFDDVL
NLRKELSNFF KKLEAETLKN DLYKSLLTSQ VPAKKTGIEV LNDVKKTIEK FLADKRTTLK
SLSVHLRNAH NITLSSQQTN SSGTANDTNT ENLLKNLKLP LSMRSYRNKS MASQLIIPES
FDELNQEVIN FYDFTEKFDE LAKNFVDQYT RSVYIASRTG LMRFYSNLTL KSPFDPRSQP
WYMGVKEAPS HVIIIIDTSF TDEKDRASFN RSKKIAQLLI NSLAAHQRVA VISSASRAWH
NKGLLQDGNA TNISECLIET SSKLSRLMKA TNGNKKMLTK AVEMLTPFGG SDHKNGFMLS
FELLERQKRV HRKYLDCRSV VLFVTDGDES EFSLRCSEGF YQFNENNERI FQKGSMCDYK
NDELLDTIQW RQSRIPGTKA KIFTFLTKES KKWHHSFFPG KLACQNNGAM SRVYHDSDLF
NQMAPYFDYI RAREYSMDPI LTGPYESSID GEPILTLSMP LLPGNNINAK KIIGVIGMDI
SLSAFESLIH EYHDFTSIIN LNDGGAIIHP LLPKSYEGVG KWMDIPIMDL EMYEEEGDNE
GTAAATATTL ATANDKYYDD DYDDDNDDKH DNLIRNNNKF KKSDHDAFPY VLKNMLRKKN
GSHVITRGVN IGVAMKEGYI LWKPAKSAYC FYDKINDTHF GVLLKAYSQT AATGFKPTDR
LFEVLDDDST KTVYKKEHLF RDKSTQWLHT WIFSTPSIPI TLDASSIVLA PSAFCHSHMS
GMQYNIDKVI VQESINKRPR DDDKVREGSG ESEADIDGEE SEERWYDALL GKEKNCLITK
EARVAIQFSK MLTYSWRQAM ARDRNLRSVY MASIAGVIRH YPGVLVPENR VLRPMRYKWF
LDAAMHTSSL NVINNRLPFT TSNNVITISR TVEETNSKND GEIVMSLSDK LDGHRFNTLQ
HEFNFIFRSL INKHMIKVHK ITRILPNCTK PTTEADKASA RSAAKAAVSA ATAVHHPPND
TVLTASFTLT TVTTVSGPQH TRACMTIVQR PYIDLQKLRK LNGVISGYST KEVKENGEVI
ADDPCYTGVF YLTSIEGTDL LFLTLIDVNI TNSDFCKNER TKSLKAFAEH MKPLCPLHEA
YYATRSNSTT CPNPRFISLY CYYNRAATDH VAIKYRLLMY MVVYLSVVHA FFEHTFLFGM
YTF
//
