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Database: UniProt
Entry: T1FAR0_HELRO
LinkDB: T1FAR0_HELRO
Original site: T1FAR0_HELRO 
ID   T1FAR0_HELRO            Unreviewed;      1242 AA.
AC   T1FAR0;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 63.
DE   RecName: Full=Kinesin motor domain-containing protein {ECO:0000259|PROSITE:PS50067};
GN   Name=20205909 {ECO:0000313|EnsemblMetazoa:HelroP176625};
GN   ORFNames=HELRODRAFT_176625 {ECO:0000313|EMBL:ESN99856.1};
OS   Helobdella robusta (Californian leech).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX   NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP176625, ECO:0000313|Proteomes:UP000015101};
RN   [1] {ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RA   Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA   Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA   Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA   Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA   Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESN99856.1, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
RN   [3] {ECO:0000313|EnsemblMetazoa:HelroP176625}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC       superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR   EMBL; AMQM01005776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KB097070; ESN99856.1; -; Genomic_DNA.
DR   RefSeq; XP_009022199.1; XM_009023951.1.
DR   AlphaFoldDB; T1FAR0; -.
DR   STRING; 6412.T1FAR0; -.
DR   EnsemblMetazoa; HelroT176625; HelroP176625; HelroG176625.
DR   GeneID; 20205909; -.
DR   KEGG; hro:HELRODRAFT_176625; -.
DR   CTD; 20205909; -.
DR   eggNOG; KOG0245; Eukaryota.
DR   HOGENOM; CLU_001485_2_3_1; -.
DR   InParanoid; T1FAR0; -.
DR   OMA; QVIFERI; -.
DR   OrthoDB; 126886at2759; -.
DR   Proteomes; UP000015101; Unassembled WGS sequence.
DR   GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR   GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR   GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IBA:GO_Central.
DR   GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR   CDD; cd22709; FHA_KIF28P; 1.
DR   Gene3D; 2.60.200.20; -; 1.
DR   Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR   InterPro; IPR000253; FHA_dom.
DR   InterPro; IPR027640; Kinesin-like_fam.
DR   InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR   InterPro; IPR019821; Kinesin_motor_CS.
DR   InterPro; IPR001752; Kinesin_motor_dom.
DR   InterPro; IPR036961; Kinesin_motor_dom_sf.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR008984; SMAD_FHA_dom_sf.
DR   PANTHER; PTHR24115:SF344; KINESIN-LIKE PROTEIN KIF28P; 1.
DR   PANTHER; PTHR24115; KINESIN-RELATED; 1.
DR   Pfam; PF00498; FHA; 1.
DR   Pfam; PF12423; KIF1B; 1.
DR   Pfam; PF00225; Kinesin; 1.
DR   PRINTS; PR00380; KINESINHEAVY.
DR   SMART; SM00240; FHA; 1.
DR   SMART; SM00129; KISc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR   PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR   PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW   ProRule:PRU00283};
KW   Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW   Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW   ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT   DOMAIN          5..357
FT                   /note="Kinesin motor"
FT                   /evidence="ECO:0000259|PROSITE:PS50067"
FT   REGION          1053..1101
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          365..392
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          912..949
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   BINDING         109..116
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ   SEQUENCE   1242 AA;  140567 MW;  8EE42C4AECD81038 CRC64;
     MGDETVKVAV RVRPFNQREK DRNAKLVIEM RGNMTLISNP DAPKEEPKKF TFDYSYWSHD
     GYSTDSDGTL RPAGNSSKYA SQKTVFDDLG RGVLKNAFEG YNCSLFAYGQ TGSGKSYSLI
     GYGPNKGIVP ITCGELFKTI DSNKDASKRY EVSFSMLEIY NEQVRDLLTK ESPKGGLPVR
     QNPQFGSFYV QGLKQVPVGS YVEIDKRMQQ GTASRTIGST DMNATRSRAH TLVTITFDQF
     IRSGASENKK SSTMNLVDLA GSERADSTGA TGDRLKEGAN INKSLSALGN VISALADSSS
     GKKKIVVPYR DSILTKLLQN ALGGNSKTIM IAALSPADIN YDETVSTLRY ADRAKRIKNK
     AIINEDPMDR LIRELREENE RLKEQIKSGK IIEQIEVTKE MSPEEIEKLK KQMMLEAMDK
     LKVNQEKIEA SVQKEKAWSK KLELARAESF ININDDRKLK EPHLMNINED LLLSGVVFHF
     LNKGVSRIGR KDAKPAPDIC FSGLSIMKHH ADIVKLSDGT FELRPMEGAK VKVNGQPIRE
     AHVLNYNDRV LFGSNHLYVF INPLDKPKSR DADVTVTWEM AQMEIAQAQG FTTTSDMSAL
     SRDKQITQEQ VLELLPIVSE VNALSEEMNK YKTFDVVLLA LDAYEGINAR PTKVMVQMKD
     LLTQNVWLWE RGKFLNRRFI MQDLYQTMLD GDLDIETIPN DEDPFWEPVE DMLLGHANIF
     LQSLAYLLDF EDSIPIRNFK GDDEGTLKVH ILPCSSNGRN LGDEHYVEQP KELVGKPYHF
     KILVKSLELH DSRHKHGLYV RYNVRGESIV QTKTDAGKNT SGCTLATFNH SHIISFPSVT
     KQHVEFFENG CVTFCVYAVQ VDCKPNPKLA KMSTKELRKL ESTDELSEKK FSERRKSMMM
     MMMTSSVTSP DASQLKSEVL LLQRKCERLE SKERRLQELC REWSKKSEED KIFEVFFGQI
     NALAFSSGRK LKTRVKMITQ PLQAVTEEND DGDDDGEMSV FVFGDDEKRL ANEANKNGGY
     LSLGAISQHF GSNGIENLME SKRNQNRRQS IMTGKPLANN NKNKNNNNNN NMINAKNKKN
     NNNKNNNNNN NNNNNNNFKS DVTAQTSSAC VLHTKSLEGV HPAWPSKFKE PFEMGLNGFT
     TVLTFPCSPF VLKSALNFVS DREVVREGGR EFQRKGPEKA NADLAKEYLT RDCFRDLFNL
     HSYIQMIRLR LSSDDDDDDG SFRWLYKPEI EWTRKDILYV TG
//
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