ID T1FAR0_HELRO Unreviewed; 1242 AA.
AC T1FAR0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 63.
DE RecName: Full=Kinesin motor domain-containing protein {ECO:0000259|PROSITE:PS50067};
GN Name=20205909 {ECO:0000313|EnsemblMetazoa:HelroP176625};
GN ORFNames=HELRODRAFT_176625 {ECO:0000313|EMBL:ESN99856.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP176625, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN99856.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP176625}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Kinesin family. {ECO:0000256|PROSITE-ProRule:PRU00283}.
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DR EMBL; AMQM01005776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097070; ESN99856.1; -; Genomic_DNA.
DR RefSeq; XP_009022199.1; XM_009023951.1.
DR AlphaFoldDB; T1FAR0; -.
DR STRING; 6412.T1FAR0; -.
DR EnsemblMetazoa; HelroT176625; HelroP176625; HelroG176625.
DR GeneID; 20205909; -.
DR KEGG; hro:HELRODRAFT_176625; -.
DR CTD; 20205909; -.
DR eggNOG; KOG0245; Eukaryota.
DR HOGENOM; CLU_001485_2_3_1; -.
DR InParanoid; T1FAR0; -.
DR OMA; QVIFERI; -.
DR OrthoDB; 126886at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005871; C:kinesin complex; IBA:GO_Central.
DR GO; GO:0005874; C:microtubule; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0003777; F:microtubule motor activity; IBA:GO_Central.
DR GO; GO:0030705; P:cytoskeleton-dependent intracellular transport; IBA:GO_Central.
DR GO; GO:0007018; P:microtubule-based movement; IBA:GO_Central.
DR CDD; cd22709; FHA_KIF28P; 1.
DR Gene3D; 2.60.200.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR027640; Kinesin-like_fam.
DR InterPro; IPR022140; Kinesin-like_KIF1-typ.
DR InterPro; IPR019821; Kinesin_motor_CS.
DR InterPro; IPR001752; Kinesin_motor_dom.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR24115:SF344; KINESIN-LIKE PROTEIN KIF28P; 1.
DR PANTHER; PTHR24115; KINESIN-RELATED; 1.
DR Pfam; PF00498; FHA; 1.
DR Pfam; PF12423; KIF1B; 1.
DR Pfam; PF00225; Kinesin; 1.
DR PRINTS; PR00380; KINESINHEAVY.
DR SMART; SM00240; FHA; 1.
DR SMART; SM00129; KISc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 1.
DR PROSITE; PS00411; KINESIN_MOTOR_1; 1.
DR PROSITE; PS50067; KINESIN_MOTOR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00283};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|PROSITE-ProRule:PRU00283};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00283}; Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 5..357
FT /note="Kinesin motor"
FT /evidence="ECO:0000259|PROSITE:PS50067"
FT REGION 1053..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 365..392
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 912..949
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 109..116
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00283"
SQ SEQUENCE 1242 AA; 140567 MW; 8EE42C4AECD81038 CRC64;
MGDETVKVAV RVRPFNQREK DRNAKLVIEM RGNMTLISNP DAPKEEPKKF TFDYSYWSHD
GYSTDSDGTL RPAGNSSKYA SQKTVFDDLG RGVLKNAFEG YNCSLFAYGQ TGSGKSYSLI
GYGPNKGIVP ITCGELFKTI DSNKDASKRY EVSFSMLEIY NEQVRDLLTK ESPKGGLPVR
QNPQFGSFYV QGLKQVPVGS YVEIDKRMQQ GTASRTIGST DMNATRSRAH TLVTITFDQF
IRSGASENKK SSTMNLVDLA GSERADSTGA TGDRLKEGAN INKSLSALGN VISALADSSS
GKKKIVVPYR DSILTKLLQN ALGGNSKTIM IAALSPADIN YDETVSTLRY ADRAKRIKNK
AIINEDPMDR LIRELREENE RLKEQIKSGK IIEQIEVTKE MSPEEIEKLK KQMMLEAMDK
LKVNQEKIEA SVQKEKAWSK KLELARAESF ININDDRKLK EPHLMNINED LLLSGVVFHF
LNKGVSRIGR KDAKPAPDIC FSGLSIMKHH ADIVKLSDGT FELRPMEGAK VKVNGQPIRE
AHVLNYNDRV LFGSNHLYVF INPLDKPKSR DADVTVTWEM AQMEIAQAQG FTTTSDMSAL
SRDKQITQEQ VLELLPIVSE VNALSEEMNK YKTFDVVLLA LDAYEGINAR PTKVMVQMKD
LLTQNVWLWE RGKFLNRRFI MQDLYQTMLD GDLDIETIPN DEDPFWEPVE DMLLGHANIF
LQSLAYLLDF EDSIPIRNFK GDDEGTLKVH ILPCSSNGRN LGDEHYVEQP KELVGKPYHF
KILVKSLELH DSRHKHGLYV RYNVRGESIV QTKTDAGKNT SGCTLATFNH SHIISFPSVT
KQHVEFFENG CVTFCVYAVQ VDCKPNPKLA KMSTKELRKL ESTDELSEKK FSERRKSMMM
MMMTSSVTSP DASQLKSEVL LLQRKCERLE SKERRLQELC REWSKKSEED KIFEVFFGQI
NALAFSSGRK LKTRVKMITQ PLQAVTEEND DGDDDGEMSV FVFGDDEKRL ANEANKNGGY
LSLGAISQHF GSNGIENLME SKRNQNRRQS IMTGKPLANN NKNKNNNNNN NMINAKNKKN
NNNKNNNNNN NNNNNNNFKS DVTAQTSSAC VLHTKSLEGV HPAWPSKFKE PFEMGLNGFT
TVLTFPCSPF VLKSALNFVS DREVVREGGR EFQRKGPEKA NADLAKEYLT RDCFRDLFNL
HSYIQMIRLR LSSDDDDDDG SFRWLYKPEI EWTRKDILYV TG
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