ID T1FB94_HELRO Unreviewed; 240 AA.
AC T1FB94;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=GDP/GTP exchange factor Sec2 N-terminal domain-containing protein {ECO:0000259|Pfam:PF06428};
GN Name=20206093 {ECO:0000313|EnsemblMetazoa:HelroP177131};
GN ORFNames=HELRODRAFT_177131 {ECO:0000313|EMBL:ESN98250.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP177131, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN98250.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP177131}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SEC2 family.
CC {ECO:0000256|ARBA:ARBA00025794}.
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DR EMBL; AMQM01005942; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097182; ESN98250.1; -; Genomic_DNA.
DR RefSeq; XP_009023593.1; XM_009025345.1.
DR AlphaFoldDB; T1FB94; -.
DR STRING; 6412.T1FB94; -.
DR EnsemblMetazoa; HelroT177131; HelroP177131; HelroG177131.
DR GeneID; 20206093; -.
DR KEGG; hro:HELRODRAFT_177131; -.
DR CTD; 20206093; -.
DR eggNOG; KOG4324; Eukaryota.
DR HOGENOM; CLU_038204_1_0_1; -.
DR InParanoid; T1FB94; -.
DR OrthoDB; 1361004at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.5.4880; -; 1.
DR InterPro; IPR040351; RAB3IL/RAB3IP/Sec2.
DR InterPro; IPR009449; Sec2_N.
DR PANTHER; PTHR14430:SF0; RAB GUANINE NUCLEOTIDE EXCHANGE FACTOR SEC2; 1.
DR PANTHER; PTHR14430; RABIN3-RELATED; 1.
DR Pfam; PF06428; Sec2p; 1.
DR SUPFAM; SSF144284; Sec2 N-terminal region; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 64..135
FT /note="GDP/GTP exchange factor Sec2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF06428"
FT COILED 57..127
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 240 AA; 27280 MW; 230A351EE78583B0 CRC64;
MDCAENNLPN GIDLLEIDDL KPLGGESSAA AAADATNSNS IKYPRHQRRS VYLFEKLQEV
QEQLKEKELQ CENLTKEQLQ TGEEVQELTA ALFEEANKMV QDANIKRRQA EKQLEDSLMK
IEVLQEEVTV LKKLILSPTT PNSPNFIKTP QLVKSSSNSN FTKGHKRSIS HHSTIRIVDD
IDTLAPYDNE IDLPRREKFR TWKACPTLNP SDPFIEDIIR NEINPCLAFK NDSVGTFNRD
//
