ID T1FBN3_HELRO Unreviewed; 355 AA.
AC T1FBN3;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 44.
DE RecName: Full=Calponin-homology (CH) domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20206232 {ECO:0000313|EnsemblMetazoa:HelroP177416};
GN ORFNames=HELRODRAFT_177416 {ECO:0000313|EMBL:ESN98171.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP177416, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN98171.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP177416}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01006055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097222; ESN98171.1; -; Genomic_DNA.
DR RefSeq; XP_009023855.1; XM_009025607.1.
DR AlphaFoldDB; T1FBN3; -.
DR STRING; 6412.T1FBN3; -.
DR EnsemblMetazoa; HelroT177416; HelroP177416; HelroG177416.
DR GeneID; 20206232; -.
DR KEGG; hro:HELRODRAFT_177416; -.
DR CTD; 20206232; -.
DR eggNOG; KOG2996; Eukaryota.
DR HOGENOM; CLU_781380_0_0_1; -.
DR InParanoid; T1FBN3; -.
DR OrthoDB; 2911406at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR45818; PROTEIN VAV; 1.
DR PANTHER; PTHR45818:SF3; PROTEIN VAV; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00033; CH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 8..125
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT DOMAIN 185..355
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
SQ SEQUENCE 355 AA; 40291 MW; F529B6700126E7F7 CRC64;
MGSMNSEDEN WYACSDWLER CAMITVEQNK SISSIEHLAT ILKDGVLLCN LCNKIKPGSI
DIKQTSQKPQ YSQFLWQRNV HTFLMACQNA FGLDKKKHLF EVPDLVELQN FGKVIFTLSK
LSQTKEARAK NIKKDMLVED DDSFSLYGTS LDDLGNSDVC EEIYDTLVYG SMQKPAAKAS
TPRTKKDSCL DELVATEKNF IDVLAMINNI FARNLKSHLS ASESNEVFFK IEDLHKVHQD
FYRKILAARN SGSPAQEVSK SFIEFKLPFT IYGDYVAHIN RSTAALDAIC TTNSPARKLI
EDGAIVAKVK LRDLLTVPVQ RILKYHIIIK DLNVYINEVK RDSENLDTTR EVQSR
//
