ID T1FBN5_HELRO Unreviewed; 1349 AA.
AC T1FBN5;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=C2 domain-containing protein {ECO:0000259|PROSITE:PS50004};
GN Name=20206234 {ECO:0000313|EnsemblMetazoa:HelroP177418};
GN ORFNames=HELRODRAFT_177418 {ECO:0000313|EMBL:ESN98173.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP177418, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN98173.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP177418}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ferlin family.
CC {ECO:0000256|ARBA:ARBA00007561}.
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DR EMBL; AMQM01006055; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01006056; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01006057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01006058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097222; ESN98173.1; -; Genomic_DNA.
DR RefSeq; XP_009023857.1; XM_009025609.1.
DR STRING; 6412.T1FBN5; -.
DR EnsemblMetazoa; HelroT177418; HelroP177418; HelroG177418.
DR GeneID; 20206234; -.
DR KEGG; hro:HELRODRAFT_177418; -.
DR CTD; 20206234; -.
DR eggNOG; KOG1326; Eukaryota.
DR HOGENOM; CLU_001183_2_1_1; -.
DR InParanoid; T1FBN5; -.
DR OMA; DLLVVEX; -.
DR OrthoDB; 991411at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR CDD; cd04011; C2B_Ferlin; 1.
DR CDD; cd04017; C2D_Ferlin; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037720; C2B_Ferlin.
DR InterPro; IPR037723; C2D_Ferlin.
DR InterPro; IPR012968; FerIin_dom.
DR InterPro; IPR037721; Ferlin.
DR InterPro; IPR012560; Ferlin_A-domain.
DR InterPro; IPR012561; Ferlin_B-domain.
DR InterPro; IPR010482; Peroxin.
DR InterPro; IPR006614; Peroxin/Ferlin.
DR PANTHER; PTHR12546; FER-1-LIKE; 1.
DR PANTHER; PTHR12546:SF33; SPERM VESICLE FUSION PROTEIN FER-1; 1.
DR Pfam; PF00168; C2; 4.
DR Pfam; PF08165; FerA; 1.
DR Pfam; PF08150; FerB; 1.
DR Pfam; PF08151; FerI; 1.
DR Pfam; PF06398; Pex24p; 1.
DR SMART; SM00239; C2; 3.
DR SMART; SM00694; DysFC; 2.
DR SMART; SM00693; DysFN; 2.
DR SMART; SM01200; FerA; 1.
DR SMART; SM01201; FerB; 1.
DR SMART; SM01202; FerI; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 3.
DR PROSITE; PS50004; C2; 3.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101}.
FT DOMAIN 16..137
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 862..992
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1044..1178
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 1..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 830..858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1349 AA; 154134 MW; 415C3FD2DB13C2D5 CRC64;
MADKIEEKAP AKRPDPKPEK REDKKEEKPK QDKPKKMRLK VIEARQLPGA NVSPTCRVSC
YNQKKQTKVI QLSNSPFWNE LFFFNFNDSP AELFDELLLF EVYDSKKLRA DSFIGSFKIE
VGMIYDEPNH CFVNKWLLLS DPEQVSDGHK GYLKISVALL GPGDDPPSFE STKYGSTTGD
DDIEANLLRP AGLVLRPATF KLKLFCAEDL PRRTLHLLTS QISQVGNEAI CKDAQIVLNA
ALTAKSLPTP GVKVKAPGYL PMFGPCFVNF YGSPREFSDL PTEFDELNSG KGVGVAYRGR
VMIELQTVLG ELPLTPIEDL TNEDIMKAQK FMRRRKFKLH STFLDATMIS INDSPVEFEV
SIGNYGNRLD EFLPPSVCST QPTNPVFDGC FYYYLPWADA KPCVVIESHW EDESQMNNIR
LAQKGNVGLT ELAMSVIKIL DDIISECQKP LPEPNPECQT SNILDRNLSE YRKAVLANIV
KEAKKLREEA TDIDESLNEP QNSIPDVMIW MITGEKRIAY YRIPSNLVIW SPNPDYRGKH
CGHLTTFMLQ YPGSKAVKEN RWEVPAMIRG RIWLGLEKDE KEWHQMSKEG ELTVFAETYE
NQVNVLGKWT NRGPTMSRPK WTDVTGKIEL NKEQFYPPPG WVWDDDWYIN PELSMLFEKD
ANHTTFMEDV YECQSRIVGG NWKPAAVPYS DVKGDACSGI KEIELPAGWE WQDDWQVDLN
RAVDENGWEY AADVTLGGYG PVEKMFHMCR RRRWLRTRNL VKTQSMQAEQ VKQKEMFAEG
WEYAPLFTMT FHLKERKMDL VRRRRWHRKM VPESKKEANS AIFQFSTALE EEKEEMEKDE
DEEGDGDGGE KKKTDEDAIA KSVTSAPRMF MYAKKGFRYQ LRAYIYQARD LLAGDSNGLS
DPFARIIFLS QSQSTEKIMK TLCPTWDQTL IFESVKIWGD PKNVFEYPPD VIMEIFDFDT
FGSAQYLGRA FGKPVVKLDP TDTKQPVLLK WYPVKKGDQD GGEVLAAFEL LLIDGPKEPP
FPPPKRGNFY MVPNGIRPQM ARTAVEVIHQ SIPVDIGVLL LARQLFSHVM CWGLRNMKKF
QLLEVSSPNV EIEINGTILE SKVIRDMSKN PNFDDPMLFF DVMLPKEELY APPINIRVKD
NRAFGRRPLV GIHTITSLEP YRCDPDDLEN DEDSDKSNQL AGSLFNNAVQ RKASVMSVKS
KDMVLAIEEE VDEDIDWWSK FYASVGEMDK CKKYVDLGYD KLQVYATELE KVKVHREFND
FCSTFPLTRG KAIDDEEGTV AGEFKGTFYV YPLPGDLQAP MPPRILKNLP TSGPVECLAD
PYIQIKIGKT KVENNNEYIP NTLNPVFGK
//
