ID T1FF83_HELRO Unreviewed; 522 AA.
AC T1FF83;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=F-box domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20207482 {ECO:0000313|EnsemblMetazoa:HelroP179892};
GN ORFNames=HELRODRAFT_179892 {ECO:0000313|EMBL:ESN95033.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP179892, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN95033.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP179892}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01007028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097552; ESN95033.1; -; Genomic_DNA.
DR RefSeq; XP_009026924.1; XM_009028676.1.
DR AlphaFoldDB; T1FF83; -.
DR STRING; 6412.T1FF83; -.
DR EnsemblMetazoa; HelroT179892; HelroP179892; HelroG179892.
DR GeneID; 20207482; -.
DR KEGG; hro:HELRODRAFT_179892; -.
DR CTD; 20207482; -.
DR eggNOG; ENOG502QTD9; Eukaryota.
DR HOGENOM; CLU_013357_0_0_1; -.
DR InParanoid; T1FF83; -.
DR OMA; RKKIWQF; -.
DR OrthoDB; 5397239at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 3.30.40.150; TRAF-like zinc-finger, N-terminal subdomain; 1.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR031890; Fbxo30/Fbxo40.
DR InterPro; IPR001293; Znf_TRAF.
DR InterPro; IPR043013; Znf_TRAF_N.
DR PANTHER; PTHR15933; PROTEIN CBG16327; 1.
DR PANTHER; PTHR15933:SF20; PROTEIN CBG16327; 1.
DR Pfam; PF15966; F-box_4; 1.
DR Pfam; PF15965; zf-TRAF_2; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR PROSITE; PS50181; FBOX; 1.
DR PROSITE; PS50145; ZF_TRAF; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00207}; Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00207};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00207}.
FT DOMAIN 46..94
FT /note="TRAF-type"
FT /evidence="ECO:0000259|PROSITE:PS50145"
FT DOMAIN 444..498
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT ZN_FING 46..94
FT /note="TRAF-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00207"
FT REGION 236..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 522 AA; 60175 MW; AE65617512860A2B CRC64;
MNSNRTEIHP HCLNCHLIGC SYQECPVISC PQRCGHKFHK CKYDDHQFLC SQMNVPCLNA
HCGCPFFVIR RQMSAHLKKC PAFVLFCNQQ WGGCIKFLHD TPSEEPSSHH CIKAQDSQLD
VALALKDKKE LYRFMKSLSK KTIQDLRYQL TSPQGSQVQT IFVPGLKERC IPSPLVILNL
DRMSFQCDNI KLCTEESISE TFEQLEKHRL DLEERCICKK LFNMCFRSSV RNYNTDDAGT
NNDSEKGNSG KVKSSDVDDV NEDCEEVWGS NGYNDDPTKS SPHTLNISPF LNHTLCLNMW
LNDYSKKIKQ SEFMYTFLCG ELLRRNEFSQ HYKNFHQDIQ CGSDSWLDVR CPLACYGCTY
SVRKFRPRFN AHLLFDRESS NFCVRPDSVF GDVSIRNSAS LESSSADVLL ENILENSEVS
NFDNSDKHIP VKAKLRDQLN ARIPILITDL PVIVLDRIFS YLDSISLKKL SLTSKQFRMI
CEEYLKERGM VVEVWEKIKC GDLCKWRATG YVCLSIINFF LI
//
