ID T1FGH1_HELRO Unreviewed; 683 AA.
AC T1FGH1;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESN93435.1, ECO:0000313|EnsemblMetazoa:HelroP180974};
GN Name=20207920 {ECO:0000313|EnsemblMetazoa:HelroP180974};
GN ORFNames=HELRODRAFT_180974 {ECO:0000313|EMBL:ESN93435.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP180974, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN93435.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP180974}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the glycosyltransferase 92 family.
CC {ECO:0000256|ARBA:ARBA00007647}.
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DR EMBL; AMQM01007424; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097612; ESN93435.1; -; Genomic_DNA.
DR RefSeq; XP_009028498.1; XM_009030250.1.
DR AlphaFoldDB; T1FGH1; -.
DR EnsemblMetazoa; HelroT180974; HelroP180974; HelroG180974.
DR GeneID; 20207920; -.
DR KEGG; hro:HELRODRAFT_180974; -.
DR CTD; 20207920; -.
DR HOGENOM; CLU_402968_0_0_1; -.
DR InParanoid; T1FGH1; -.
DR OrthoDB; 34939at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016757; F:glycosyltransferase activity; IBA:GO_Central.
DR GO; GO:0070085; P:glycosylation; IBA:GO_Central.
DR InterPro; IPR008166; Glyco_transf_92.
DR PANTHER; PTHR21461:SF69; GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN; 1.
DR PANTHER; PTHR21461; UNCHARACTERIZED; 1.
DR Pfam; PF01697; Glyco_transf_92; 1.
PE 3: Inferred from homology;
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..683
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010980714"
FT REGION 24..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 641..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 641..659
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 683 AA; 80613 MW; 756C97C25B616AC6 CRC64;
MLWMFADVTK LIFILLWPSS ETNLEKDKRP SQNNDEQCRF SIPDSTGTKI NETNFEKLHW
HRVGNKTSRE VTYVFSAFLD IRNENPSIRI LGITEASNYD AQVKYCRVWD ENSNVQIAVL
SVGSVTNETL VRSKYYEMLY TCTIALHHKF MKPAYVTLIN AECDEPNFYL LVYHSDLYQH
RLDYFKTNSL HHHYPKHNQE HQKSMFEQHL SKRNLTFKGK HREETDDLFI SSTKHVPQNS
TVDFTICSPT RVVSEIPFQF FIEWIELNRH LGVQRFFIFK LRTQDENKRS KKFKDNSNNK
LKLNYLFKYY QHLGLLTIIE WSFPVKYDQN RDSLIMENSY IIGIDIALTY CLYLNMYKTK
YIMNLALDEY VTSARYYNLS TFFEKFEHDA LHNNERNNIS STNDDKNNSH ILNSMEKDQV
ALFYFPTVFY SIFGDLNMEM KKTHEHMFKT SILLRRFSKI FKFKSKYVVR ATAAQWLTLF
DAHLLQTFVH HNFSESAALM RSFLLLRLMR ANDEFPLDDK VVNPPDDVSF ESHVTFVYNI
LPTFFDVGSF MTTRDVDEND VNNSDTNSTA TETLFDDINV NGRDDSEVNR EEENFKKWIE
QNTEIDLYME AYEMTLWKRF LFVLNLSNIT DLLFEEEYAQ YGDDGSRPER KKDGDIDDGD
SDGNVSFVSE NDAGAALYVD NED
//
