ID T1FGX4_HELRO Unreviewed; 419 AA.
AC T1FGX4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=K Homology domain-containing protein {ECO:0000259|SMART:SM00322};
GN Name=20208073 {ECO:0000313|EnsemblMetazoa:HelroP181360};
GN ORFNames=HELRODRAFT_181360 {ECO:0000313|EMBL:ESN92488.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP181360, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN92488.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP181360}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AMQM01007553; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AMQM01007554; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097640; ESN92488.1; -; Genomic_DNA.
DR RefSeq; XP_009029420.1; XM_009031172.1.
DR AlphaFoldDB; T1FGX4; -.
DR EnsemblMetazoa; HelroT181360; HelroP181360; HelroG181360.
DR GeneID; 20208073; -.
DR KEGG; hro:HELRODRAFT_181360; -.
DR CTD; 20208073; -.
DR eggNOG; KOG2193; Eukaryota.
DR HOGENOM; CLU_656013_0_0_1; -.
DR InParanoid; T1FGX4; -.
DR OMA; NWAICAI; -.
DR OrthoDB; 3035007at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003730; F:mRNA 3'-UTR binding; IBA:GO_Central.
DR GO; GO:0007399; P:nervous system development; IBA:GO_Central.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR CDD; cd22401; KH-I_IGF2BP_rpt2; 1.
DR Gene3D; 3.30.310.210; -; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR PANTHER; PTHR10288:SF337; IGF-II MRNA-BINDING PROTEIN, ISOFORM L; 1.
DR PANTHER; PTHR10288; KH DOMAIN CONTAINING RNA BINDING PROTEIN; 1.
DR Pfam; PF00013; KH_1; 3.
DR SMART; SM00322; KH; 3.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 3.
DR PROSITE; PS50084; KH_TYPE_1; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT DOMAIN 67..144
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 177..250
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT DOMAIN 261..332
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT REGION 306..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 371..398
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 419 AA; 47822 MW; A9560E12F374E04D CRC64;
MGAGLCVGER GVCSREEGLP FRILKNFEFY DLNYFQTSLR IDVHGKENSG LLEKLVSIFG
KPDSCTRACQ EIMACLHKSQ INNNARIIGR DGRGIRKVRE DSEARISISN VQEMASLYPD
RVITIRGTLE SMSLAESAIS ERLRECYRKE EYYYARQQQQ QLMPSTSQQR QPTQQQPHSI
CHIGIPNFAV GAIIGAAGAN IKRIIRDSNA LVTVEARRDE QTPADERIAT VKGTPDSCWR
ASYYIFEKMK QEGFGGSDGE VRLRTIITIP RSAAGRVVGK GGKCVREIQR LTGAMIRLAV
DASREQQQQQ QQISPPQQQI SPQQQRLTLQ QQQQQQQHPQ FSKQFQSQFQ QLPLEPQQLP
QCLPQQQEMI LQQQRQHYQQ QQQQQQQQRQ RLEELVLVEI FGNFISTQVV SIVLLGYCC
//
