ID T1FH11_HELRO Unreviewed; 901 AA.
AC T1FH11;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=BEACH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20208110 {ECO:0000313|EnsemblMetazoa:HelroP181462};
GN ORFNames=HELRODRAFT_181462 {ECO:0000313|EMBL:ESN92414.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP181462, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN92414.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP181462}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
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DR EMBL; AMQM01007607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097642; ESN92414.1; -; Genomic_DNA.
DR RefSeq; XP_009029508.1; XM_009031260.1.
DR AlphaFoldDB; T1FH11; -.
DR STRING; 6412.T1FH11; -.
DR EnsemblMetazoa; HelroT181462; HelroP181462; HelroG181462.
DR GeneID; 20208110; -.
DR KEGG; hro:HELRODRAFT_181462; -.
DR CTD; 20208110; -.
DR eggNOG; KOG1787; Eukaryota.
DR HOGENOM; CLU_000218_5_0_1; -.
DR InParanoid; T1FH11; -.
DR OMA; WITGVES; -.
DR OrthoDB; 5478899at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR CDD; cd06071; Beach; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR010508; NBEA-like_DUF1088.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF160; NEUROBEACHIN; 1.
DR Pfam; PF02138; Beach; 2.
DR Pfam; PF06469; DUF1088; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 181..307
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 244..493
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REPEAT 812..843
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
SQ SEQUENCE 901 AA; 101370 MW; B384A056B61A3504 CRC64;
MDRKNEEKMC NHLITSARRR DHVIASKQRD RVINLLTNRH GAWGESSEIV QLQSTKQLQK
QQHQQLFQQQ QQLGFWKLDN WEDDSRRRRR FVRNPFGTKH ADATLKAAIE HGATEDAINA
AREAYKLHHH QQYHHASANM VAAMVSGGAA AGGVSRNHQQ QVQDTSEEDL SQMDERDLEV
EFSGPVALST HCKLISPGCA VNGTLSITKV ELYFEMDEDD ERNKKILRRS GRSSTFCPGR
VSMASPKQIF KMSNMTQKWQ RREITNFDYL MYLNTVAGRT YCDLNQYPVY PWVIVNYESS
DLDLNLATNY RDLSKPIGAL NPTRRSFFEE RYNQWDNTDV PAFHYGTHYS TAAFVLNWLI
RVELIPEFYY LSDMFVNTNN CTLGTNDDGD NINNVILPPW AKSPEDFVRI MRMALESEIV
SIQLHQWIDL IFGYKQRGPE AIRSTNVFYY LTYEGSVNLD SISDPVLREA IENQIQSFGQ
TPSQLLTEPH PPRSSPMNLS PMMFTTIPDD VCMIMKFLSN SPVTHVSANT HPSVPTPAVI
TLTCNYNFAV NKWNHAAASS QVPTPGFSDK SEHQSQLPLT MDQLLGEIRV MRLRVIHSSF
VVTADNRHII AVGFWDRSFR VFNIETAKIT QTIFGHLSIV TCVARSECSV SQDCYVVTGS
KDCTLMLWHW VAKQQCILGD NGSSENATPK ATLTGHKSEV TCAIVSAELG IVVSGSLGGP
VLIHTNTGDL LRSLDVPDVI NPQLPLPSSS SSSLSSVLSS SVSSSSSSAA AARQTVVPTP
RLISLNREGY ITVAYDNGAL CSFSINGKVQ KYLLHNSNIQ CMIMNRDGQY LILSGDNGVV
EVWRSYDLTV LYSYPKCDSS VRSLALSHDQ KFLMAGLATG CLIVFNIDFN RWNPEFQEKY
Q
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