ID T1FMI0_HELRO Unreviewed; 523 AA.
AC T1FMI0;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 24-JAN-2024, entry version 59.
DE RecName: Full=LisH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=20210029 {ECO:0000313|EnsemblMetazoa:HelroP185199};
GN ORFNames=HELRODRAFT_185199 {ECO:0000313|EMBL:ESN91742.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP185199, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN91742.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP185199}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- SIMILARITY: Belongs to the WD repeat EBI family.
CC {ECO:0000256|ARBA:ARBA00025741}.
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DR EMBL; AMQM01002177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097700; ESN91742.1; -; Genomic_DNA.
DR RefSeq; XP_009030551.1; XM_009032303.1.
DR AlphaFoldDB; T1FMI0; -.
DR STRING; 6412.T1FMI0; -.
DR EnsemblMetazoa; HelroT185199; HelroP185199; HelroG185199.
DR GeneID; 20210029; -.
DR KEGG; hro:HELRODRAFT_185199; -.
DR CTD; 20210029; -.
DR eggNOG; KOG0273; Eukaryota.
DR HOGENOM; CLU_007609_2_0_1; -.
DR InParanoid; T1FMI0; -.
DR OMA; KWNKCGN; -.
DR OrthoDB; 5481136at2759; -.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
DR GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 1.20.960.30; -; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR045183; Ebi-like.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR006594; LisH.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22846:SF2; F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN EBI; 1.
DR PANTHER; PTHR22846; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF08513; LisH; 1.
DR Pfam; PF00400; WD40; 6.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00667; LisH; 1.
DR SMART; SM00320; WD40; 8.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50896; LISH; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT REPEAT 134..175
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 237..261
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 271..312
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 354..395
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 396..446
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 447..488
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 170..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 523 AA; 56306 MW; 96DF8552EC273A30 CRC64;
MSFSSDEVNY LVYRYLIESG FTHAAYTFGI ESHISHSNIN GSIVPPAALL NIIQKGLQYT
EAEISIAEDG TERTVEAISL IDAVLPDFIE HKKQGTTTKG MNQCKPEKAG VDDDKEMMEL
DTGIEIPASK SVILKGHESE VFICAWNPTN DLLASGSGDS TARIWNLNES SSSTPVSTSA
ASASSSSLPG EAGNSVTAVS STSGTVISGG SAAGANQLVL RHCIQKGGTE VPSNKDVTSL
DWNCDGTLLA TGSYDGYARI WATDGHLVST LGQHKGPIFA LKWNKKGNYI LSAGVDKTTI
IWDASSGRCT QQFGFHNAPA LDVDWKDNMT FASCSTDQCI HVCKLGTDKP IKTFQGHTNE
VNAIKWDPQG VLLASCSDDM TLKIWSLKQD TCIHDLQAHN KEIYTIKWSP TGPGTNNPNA
SLILASASFD STVRLWDVER GVCVHKLTRH LEPVYSVAFS PDGKHIASGS FDKCVHIWSV
QTGALVHTYR GTGGIFEVCW NYRGDKVGAS ASDGSVFVLD LRK
//