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Database: UniProt
Entry: T1FMI0_HELRO
LinkDB: T1FMI0_HELRO
Original site: T1FMI0_HELRO 
ID   T1FMI0_HELRO            Unreviewed;       523 AA.
AC   T1FMI0;
DT   16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT   16-OCT-2013, sequence version 1.
DT   24-JAN-2024, entry version 59.
DE   RecName: Full=LisH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN   Name=20210029 {ECO:0000313|EnsemblMetazoa:HelroP185199};
GN   ORFNames=HELRODRAFT_185199 {ECO:0000313|EMBL:ESN91742.1};
OS   Helobdella robusta (Californian leech).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC   Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX   NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP185199, ECO:0000313|Proteomes:UP000015101};
RN   [1] {ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RA   Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA   Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA   Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA   Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA   Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL   Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:ESN91742.1, ECO:0000313|Proteomes:UP000015101}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
RN   [3] {ECO:0000313|EnsemblMetazoa:HelroP185199}
RP   IDENTIFICATION.
RG   EnsemblMetazoa;
RL   Submitted (JUN-2015) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the WD repeat EBI family.
CC       {ECO:0000256|ARBA:ARBA00025741}.
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DR   EMBL; AMQM01002177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KB097700; ESN91742.1; -; Genomic_DNA.
DR   RefSeq; XP_009030551.1; XM_009032303.1.
DR   AlphaFoldDB; T1FMI0; -.
DR   STRING; 6412.T1FMI0; -.
DR   EnsemblMetazoa; HelroT185199; HelroP185199; HelroG185199.
DR   GeneID; 20210029; -.
DR   KEGG; hro:HELRODRAFT_185199; -.
DR   CTD; 20210029; -.
DR   eggNOG; KOG0273; Eukaryota.
DR   HOGENOM; CLU_007609_2_0_1; -.
DR   InParanoid; T1FMI0; -.
DR   OMA; KWNKCGN; -.
DR   OrthoDB; 5481136at2759; -.
DR   Proteomes; UP000015101; Unassembled WGS sequence.
DR   GO; GO:0000118; C:histone deacetylase complex; IBA:GO_Central.
DR   GO; GO:0003714; F:transcription corepressor activity; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00200; WD40; 1.
DR   Gene3D; 1.20.960.30; -; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR045183; Ebi-like.
DR   InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR   InterPro; IPR006594; LisH.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR22846:SF2; F-BOX-LIKE/WD REPEAT-CONTAINING PROTEIN EBI; 1.
DR   PANTHER; PTHR22846; WD40 REPEAT PROTEIN; 1.
DR   Pfam; PF08513; LisH; 1.
DR   Pfam; PF00400; WD40; 6.
DR   PRINTS; PR00320; GPROTEINBRPT.
DR   SMART; SM00667; LisH; 1.
DR   SMART; SM00320; WD40; 8.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50896; LISH; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 3.
DR   PROSITE; PS50082; WD_REPEATS_2; 6.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 5.
PE   3: Inferred from homology;
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   REPEAT          134..175
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          237..261
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          271..312
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          354..395
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          396..446
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          447..488
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REGION          170..195
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   523 AA;  56306 MW;  96DF8552EC273A30 CRC64;
     MSFSSDEVNY LVYRYLIESG FTHAAYTFGI ESHISHSNIN GSIVPPAALL NIIQKGLQYT
     EAEISIAEDG TERTVEAISL IDAVLPDFIE HKKQGTTTKG MNQCKPEKAG VDDDKEMMEL
     DTGIEIPASK SVILKGHESE VFICAWNPTN DLLASGSGDS TARIWNLNES SSSTPVSTSA
     ASASSSSLPG EAGNSVTAVS STSGTVISGG SAAGANQLVL RHCIQKGGTE VPSNKDVTSL
     DWNCDGTLLA TGSYDGYARI WATDGHLVST LGQHKGPIFA LKWNKKGNYI LSAGVDKTTI
     IWDASSGRCT QQFGFHNAPA LDVDWKDNMT FASCSTDQCI HVCKLGTDKP IKTFQGHTNE
     VNAIKWDPQG VLLASCSDDM TLKIWSLKQD TCIHDLQAHN KEIYTIKWSP TGPGTNNPNA
     SLILASASFD STVRLWDVER GVCVHKLTRH LEPVYSVAFS PDGKHIASGS FDKCVHIWSV
     QTGALVHTYR GTGGIFEVCW NYRGDKVGAS ASDGSVFVLD LRK
//
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