ID T1FMI4_HELRO Unreviewed; 407 AA.
AC T1FMI4;
DT 16-OCT-2013, integrated into UniProtKB/TrEMBL.
DT 16-OCT-2013, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=adenosine kinase {ECO:0000256|ARBA:ARBA00012119};
DE EC=2.7.1.20 {ECO:0000256|ARBA:ARBA00012119};
GN Name=20210033 {ECO:0000313|EnsemblMetazoa:HelroP185207};
GN ORFNames=HELRODRAFT_185207 {ECO:0000313|EMBL:ESN90364.1};
OS Helobdella robusta (Californian leech).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Annelida; Clitellata;
OC Hirudinea; Rhynchobdellida; Glossiphoniidae; Helobdella.
OX NCBI_TaxID=6412 {ECO:0000313|EnsemblMetazoa:HelroP185207, ECO:0000313|Proteomes:UP000015101};
RN [1] {ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RA Hellsten U., Grimwood J., Chapman J.A., Shapiro H., Aerts A., Otillar R.P.,
RA Terry A.Y., Boore J.L., Simakov O., Marletaz F., Cho S.-J.,
RA Edsinger-Gonzales E., Havlak P., Kuo D.-H., Larsson T., Lv J., Arendt D.,
RA Savage R., Osoegawa K., de Jong P., Lindberg D.R., Seaver E.C.,
RA Weisblat D.A., Putnam N.H., Grigoriev I.V., Rokhsar D.S.;
RL Submitted (DEC-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ESN90364.1, ECO:0000313|Proteomes:UP000015101}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
RN [3] {ECO:0000313|EnsemblMetazoa:HelroP185207}
RP IDENTIFICATION.
RG EnsemblMetazoa;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- PATHWAY: Purine metabolism; AMP biosynthesis via salvage pathway; AMP
CC from adenosine: step 1/1. {ECO:0000256|ARBA:ARBA00004801}.
CC -!- SIMILARITY: Belongs to the carbohydrate kinase PfkB family.
CC {ECO:0000256|ARBA:ARBA00010688}.
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DR EMBL; AMQM01002243; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; KB097753; ESN90364.1; -; Genomic_DNA.
DR RefSeq; XP_009031312.1; XM_009033064.1.
DR AlphaFoldDB; T1FMI4; -.
DR STRING; 6412.T1FMI4; -.
DR EnsemblMetazoa; HelroT185207; HelroP185207; HelroG185207.
DR GeneID; 20210033; -.
DR KEGG; hro:HELRODRAFT_185207; -.
DR CTD; 20210033; -.
DR eggNOG; KOG2854; Eukaryota.
DR HOGENOM; CLU_045832_0_0_1; -.
DR InParanoid; T1FMI4; -.
DR OMA; TTEFPVQ; -.
DR OrthoDB; 22683at2759; -.
DR UniPathway; UPA00588; UER00659.
DR Proteomes; UP000015101; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004001; F:adenosine kinase activity; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0044209; P:AMP salvage; IEA:UniProtKB-UniPathway.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006144; P:purine nucleobase metabolic process; IBA:GO_Central.
DR GO; GO:0006166; P:purine ribonucleoside salvage; IEA:UniProtKB-KW.
DR CDD; cd01168; adenosine_kinase; 1.
DR Gene3D; 3.30.1110.10; -; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR InterPro; IPR001805; Adenokinase.
DR InterPro; IPR011611; PfkB_dom.
DR InterPro; IPR029056; Ribokinase-like.
DR PANTHER; PTHR45769; ADENOSINE KINASE; 1.
DR PANTHER; PTHR45769:SF3; ADENOSINE KINASE; 1.
DR Pfam; PF00294; PfkB; 1.
DR PRINTS; PR00989; ADENOKINASE.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Purine salvage {ECO:0000256|ARBA:ARBA00022726};
KW Reference proteome {ECO:0000313|Proteomes:UP000015101};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 113..395
FT /note="Carbohydrate kinase PfkB"
FT /evidence="ECO:0000259|Pfam:PF00294"
SQ SEQUENCE 407 AA; 45295 MW; D44F50C0617D2D10 CRC64;
MNRSNNNNNN SRLLNSNEMA VQDNINNNYD DLDSKANVVD ILSFNCRKNC SIGGEDHVMG
GHVEGVLFAI GNPLLDLIGE VKPEFLQKHK LNPEDCIVLT SHPTDIVNDF LSNHKVLHVP
GGATQNSIRI AQWLIGVPHA TSFMGCIKRD EIGQILEKKV RDEQVNCCYV YDDSEPTGKC
VICLTGSQRT YVAYLGAARH LKSSHLDDPL IWSHVAKARY YYFSGFPLIN CPDVLLRVSR
FAVENDRLVA FNLSTVSICR DYLPQVLQLL PYIDVLFGNQ EEAYAFAQAK GLQLTEIRDI
ALYMARYRKE NGKRGRHIIL TNGDQPTLVV QEGVITEFPV IRMDPKDVVD LNGAGDAFVG
GFLAQLVQGG SIQDCIRSAN YAANFIIQQS GCQLPFKPDF SHGAISF
//
